PROSITE entry PS52047

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PURL: https://purl.expasy.org/prosite/signature/PS52047

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General information about the entry

Entry name [info]	I_EGF_2
Accession [info]	PS52047
Entry type [info]	MATRIX
Date [info]	27-NOV-2024 CREATED; 27-NOV-2024 DATA UPDATE; 27-NOV-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00216
Associated ProRule [info]	PRU01392

Name and characterization of the entry

Description [info]

Integrins beta chain EGF (I-EGF) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=37;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=37;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.3892810; R2=0.0048637; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1874; N_SCORE=12.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=640; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-112; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='C';  M=-209, 159,-227,-226,-216,-224,-225,-225, -26,-216,-215,-214,-238,-228,-226,-211,-208,-213,-242, -10;
/M: SY='D';  M= -71,-224,  70, -45,-226, -64,  46,-224,-197, -18,-215, -16,  34,  46, -21,  47, -31,-221,-233,-212;
/M: SY='D';  M= -58,-250,  53, -60, -21, -62,-206, -35,  37,   6, -23,  49,-216,  -8,  13, -11,  34, -73,-229,-210;
/I:         I=-14; MD=-34;
/M: SY='Q';  M=   5,-230,  42, -49,  43,   8,  13, -65,-203,-215,-152,-201, -20,  45,  -3, -13,  31,-104,   2,-204; D=-14;
/I:         I=-14; MD=-34;
/M: SY='S';  M=  -7,-220,   2,  34,-220, -10,-209, -33, -43, -39,  13,  43,   6,   5, -54,  43, -20, -29,-231,-216; D=-14;
/I:         I=-14; MI=0; MD=-34; IM=0; DM=-34;
/M: SY='C';  M=-221, 149,-241,-241,-231,-237,-241,-238,-237,-229,-229,-227,-252,-245,-243,-224,-221,-226,-261,-242; D=-14;
/I:         I=-14; DM=-34;
/M: SY='R';  M=-104,-237, -23,  12, -59,-235, -25, -26,  28,  10, -48,-221, -69, -38,  37, -58, -69,  -1,-237,-222; D=-14;
/I:         I=-14; MI=0; MD=-34; IM=0; DM=-34;
/M: SY='N';  M= -11,-225,  10,  47,-223, -41,   8, -42, -67,-222,-215,  50,-217,  13,  47,  21, -11, -46,-229,  -1; D=-14;
/I:         I=-14; DM=-34;
/M: SY='P';  M= -72,-224, -52,  29,-215, -42,  50, -41,-204, -40,-209,  14,  70,-203,   3,  34,  10,  -8,-224,  28; D=-14;
/I:         I=-14; DM=-34;
/M: SY='N';  M= -71,-223,  71,  19,-229, -36,  13,-228,   5,-228,-220,  79,-216,  -1,   2,  17, -29,-225,-238,-216; D=-14;
/I:         I=-14; DM=-34;
/M: SY='G';  M= -34,-222, -31, -55,-228,  74, -17,-230, -55,-228,-219,-197,-215,  37,  21,  64,-203,-224,-226,-218; D=-14;
/I:         I=-14; DM=-34;
/M: SY='P';  M=  18,-223, -64, -18, -23, -34,  -9, -13,  12, -13,-205, -10,  63,  49, -33,   9,-204,  13,-225,-213; D=-14;
/I:         I=-14; DM=-34;
/M: SY='I';  M=-209,-221,   5,   0, -61,-228,  -8,  53, -12,  39, -23,-215, -18,-209,  29, -55,-205,  47,-225,-206;
/M: SY='C';  M=-208, 162,-228,-228,-219,-224,-228,-225,-224,-216,-216,-214,-239,-232,-231,-211,-208,-213,-248,-229;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='S';  M= -13,-215, -37,   8,-223,  15,  45,-224,-203,-225,-216,  48,-212,-197,-208,  94, -61,-217,-231,-213;
/M: SY='G';  M= -67,-223, -26, -18, -32, 101,-213,-234, -27,-230,-220,  12,-215,   4,-216,-197,-212,-228,-221,-220;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='R';  M= -71,-224,-203,-201, -67,-216,  78,-223,   5, -24,-208,  62,-220, -23,  88, -32,  -4,-220,-230,-206; D=-38;
/I:         I=-38; DM=-97;
/M: SY='G';  M= -38,-223,-212,-223,-230, 111,-236,-237,-217,-233,-222,-198,-215,-214,-224,-196,-215,-230,-221,-225;
/M: SY='H';  M=-207,-221,  54,  28, -28,-230,  56, -38,  -3, -55,-208,-197,-214,   4,  33,   3,  52,  17,-231,-207;
/M: SY='C';  M=-210, 149,-228,-227,  27,-225,-220,-213,-223, -13,  21,-217,-236,-228,-227,-213,-209,-208,-227,  25;
/M: SY='V';  M=-206,-221,  14,  48,  10,-220,   1,  -7,  -8, -48,-203,   6,-217,  42,   4,   6,-203,  53,-223,  -8;
/M: SY='C';  M= -37, 159,-228,-227,-218,-223,-227,-223,-223,-214,   3,-214,-237,-230,-229,-260,-208,-212,-246,-228;
/M: SY='G';  M=-197,-223,-208,-221,-229, 107,-214,-236,-213,-233,-222,  34,-216,-212, -49,-196,-213,-231,-223,-224;
/M: SY='Q';  M= -51,-222, -52, -20,-216,-220, -27, -23,  26, -19,-200, -24,-218,  81,  53, -65, -26,  51,-225,-209;
/M: SY='C';  M=-208, 162,-228,-228,-219,-224,-228,-225,-224,-216,-216,-214,-239,-232,-231,-211,-208,-213,-248,-229;
/M: SY='Q';  M= -55,-222, -64,  45,-212,-222,   2,  -5,   5,   8,-199,-207,-217,  46,  45,  -7, -27,  44,-225, -46;
/M: SY='C';  M=-208, 162,-228,-228,-219,-224,-228,-225,-224,-216,-216,-214,-239,-232,-231,-211,-208,-213,-248,-229;
/M: SY='H';  M= -38,-221,  43,  20,  23, -56,  96, -66,   5, -72,-210,  29,-215,-198, -34,  26,  12,-217,  -3, -40;
/M: SY='P';  M= -10,-224,  35,  18,-222, -16,-207,-217,  15, -73, -23, -19,  81,  17,-206,  25,  -6, -42,-225,  -2;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='G';  M=-201,-223, -25,-210,-223,  88,-210, -71,  27, -33,-215,   1,-216,   6,  21, -40, -51,-223,-221, -36;
/M: SY='W';  M= -46,-228,-223,-219, -23,-221,  14,  26,-210,-203,-202, -25,-225,-210,  17,  -2,-211,  17, 127,  92;
/M: SY='Y';  M=-205,-219,-209,  17, -23, -49,   0,  12,-207,   3,  -6, -52,-217,  29,-210,  39,  50, -17,-210,  73;
/M: SY='G';  M=-197,-224, -47,-221,-228, 108,-217,-233,-215, -45,-220,-198, -24,-214, -55,-198,-215,-229,-221,-224;
/M: SY='P';  M= -38,-225,  38,   7,-225,-213, -22,-223,  47,-223,-214, -52,  62,  43,  30,  19,  16,-220,-226, -36;
/M: SY='Y';  M=   6,-220, -52,-209,  48,-218,  -2, -56,  19,  16, -24,  20,-221, -25,  34, -35,  15,-205,-206,  69;
/M: SY='C';  M=-208, 162,-228,-228,-219,-224,-228,-225,-224,-216,-216,-214,-239,-232,-231,-211,-208,-213,-248,-229;
/M: SY='E';  M=-207,-227,   9, 105,-230,-218,-199, -40,-190,-222,-216,  33,-207,  62,-198, -61,-206,-221,-228,-218;
/I:         E1=0; IE=-380; DE=-380;

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Post-processing [info]

COMPETES_HIT_WITH

PS50026

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	220 in 50 different sequences
Number of true positive hits	220 in 50 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	10
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	I-EGF
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

50 sequences

ITB1A_XENLA (P12606), ITB1B_XENLA (P12607), ITB1_BOVIN  (P53712),

ITB1_CAMBA  (A5Z1X6), ITB1_CHICK  (P07228), ITB1_FELCA  (P53713), 
ITB1_HUMAN  (P05556), ITB1_MOUSE  (P09055), ITB1_PIG(Q9GLP0), 
ITB1_PONAB  (Q5RCA9), ITB1_RAT(P49134), ITB1_SHEEP  (B0FYY4), 
ITB2L_MOUSE (Q3UV74), ITB2_BOVIN  (P32592), ITB2_CAPHI  (Q5VI41), 
ITB2_HUMAN  (P05107), ITB2_MOUSE  (P11835), ITB2_OVICA  (Q2VJ42), 
ITB2_PIG(P53714), ITB2_SHEEP  (Q6ECI6), ITB3_HUMAN  (P05106), 
ITB3_MOUSE  (O54890), ITB3_RAT(Q8R2H2), ITB4_HUMAN  (P16144), 
ITB4_MOUSE  (A2A863), ITB4_RAT(Q64632), ITB5_BOVIN  (P80747), 
ITB5_HUMAN  (P18084), ITB5_MOUSE  (O70309), ITB5_PAPCY  (Q07441), 
ITB6_BOVIN  (Q8SQB8), ITB6_CAVPO  (P18563), ITB6_HUMAN  (P18564), 
ITB6_MOUSE  (Q9Z0T9), ITB6_PIG(Q1RPR6), ITB6_RAT(Q6AYF4), 
ITB6_SHEEP  (Q863C4), ITB7_HUMAN  (P26010), ITB7_MOUSE  (P26011), 
ITB8_HUMAN  (P26012), ITB8_MOUSE  (Q0VBD0), ITB8_RABIT  (P26013), 
ITBL_CAEEL  (Q9GYK2), ITBN_DROME  (Q27591), ITBX_DROME  (P11584), 
ITGBL_HUMAN (O95965), ITGBL_MOUSE (Q8VDV0), ITGBL_RAT   (Q5PQQ8), 
ITGBL_XENLA (Q5M9B3), PAT3_CAEEL  (Q27874)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

133 PDB

pdb_00001jv2; pdb_00001l3y; pdb_00001l5g; pdb_00001m1x; pdb_00001u8c; pdb_00001yuk; pdb_00002p26; pdb_00002p28; pdb_00002vc2; pdb_00002vdk; pdb_00002vdl; pdb_00002vdm; pdb_00002vdn; pdb_00002vdo; pdb_00002vdp; pdb_00002vdq; pdb_00002vdr; pdb_00003fcs; pdb_00003fcu; pdb_00003ije; pdb_00003k6s; pdb_00003k71; pdb_00003k72; pdb_00003nid; pdb_00003nif; pdb_00003nig; pdb_00003t3m; pdb_00003t3p; pdb_00003v4p; pdb_00003v4v; pdb_00003zdx; pdb_00003zdy; pdb_00003zdz; pdb_00003ze0; pdb_00003ze1; pdb_00003ze2; pdb_00004cak; pdb_00004g1e; pdb_00004g1m; pdb_00004mmx; pdb_00004mmy; pdb_00004mmz; pdb_00004neh; pdb_00004nen; pdb_00004o02; pdb_00004um8; pdb_00004um9; pdb_00004z7n; pdb_00004z7o; pdb_00004z7q; pdb_00005e6r; pdb_00005e6s; pdb_00005e6u; pdb_00005e6v; pdb_00005e6w; pdb_00005e6x; pdb_00005es4; pdb_00005hdb; pdb_00005nem; pdb_00005ner; pdb_00005net; pdb_00005neu; pdb_00006avq; pdb_00006avr; pdb_00006avu; pdb_00006bxb; pdb_00006bxf; pdb_00006bxj; pdb_00006ckb; pdb_00006djp; pdb_00006mk0; pdb_00006msl; pdb_00006msu; pdb_00006naj; pdb_00006uja; pdb_00006ujb; pdb_00006ujc; pdb_00006v4p; pdb_00007l8p; pdb_00007la4; pdb_00007nwl; pdb_00007nxd; pdb_00007p2d; pdb_00007tct; pdb_00007td8; pdb_00007tho; pdb_00007tmz; pdb_00007tpd; pdb_00007u60; pdb_00007u9f; pdb_00007u9v; pdb_00007ubr; pdb_00007ucy; pdb_00007udg; pdb_00007udh; pdb_00007ue0; pdb_00007ufh; pdb_00007uh8; pdb_00007uje; pdb_00007ujk; pdb_00007uk9; pdb_00007uko; pdb_00007ukp; pdb_00007ukt; pdb_00007usl; pdb_00007usm; pdb_00008gcd; pdb_00008gce; pdb_00008ij5; pdb_00008oxz; pdb_00008t2u; pdb_00008t2v; pdb_00008vs6; pdb_00008xei; pdb_00008xek; pdb_00008xel; pdb_00008xen; pdb_00008xer; pdb_00008xez; pdb_00008xf6; pdb_00008xfg; pdb_00008xfo; pdb_00008zjf; pdb_00009axl; pdb_00009b9j; pdb_00009b9k; pdb_00009ckv; pdb_00009cz7; pdb_00009cza; pdb_00009czd; pdb_00009czf; pdb_00009deq; pdb_00009der
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