ProRule PRU00098
General rule information
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| Accession | PRU00098 |
| Dates | 12-DEC-2003 (Created)
23-FEB-2024 (Last updated, Version 11) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50221; GAIN_B |
Name | GAIN-B domain |
| Function | The ~320-residue GAIN domain is an ancient domain that exists in primitive ancestor organisms, and is conserved in all adhesion-G-protein- coupled receptors (aGPCRs), all polycystic kidney disease 1 (PKD1)-like proteins and in other membrane-associated proteins like the sea urchin receptor for egg jelly protein (REJ). Functionally, the GAIN domain is both necessary and sufficient for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q8IZF7 (AGRF2_HUMAN); |
Propagated annotation
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Comments
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| case <Feature:PS50221:145-147=H-[LM]-[TSC]> | |
| SUBUNIT | Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C- terminal fragment predominantly remain associated and non-covalently linked. |
| PTM | Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity. |
| end case | |
Keywords
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| Glycoprotein | |
| Membrane | |
| Transmembrane | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| GO:0016020; Cellular component:membrane |
Features
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| From: PS50221 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="GAIN-B #" | |||||||||
| REGION | 112 | to | /note="GPS #" | |||||||||
| REGION | 147 | to | /note="Stachel #" | |||||||||
| case <Feature:PS50221:145-147=H-[LM]-[TSC]> | ||||||||||||
| SITE | 146 | 147 | /note="Cleavage; by autolysis" | |||||||||
| end case | ||||||||||||
| DISULFID | 112 | 141 | disulf | C-x*-C | ||||||||
| DISULFID | 129 | 143 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 47-59 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [116] All [ 116 ]
- Retrieve set of proteins with 3D structure for this domain