ProRule PRU00121
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00121 |
| Accession | PRU00121 |
| Dates | 12-DEC-2003 (Created)
20-NOV-2019 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50070; KRINGLE_2 |
Name | Kringle domain |
| Function | Kringle domains are thought to play a role in binding mediators, such as membranes, other proteins or phospholipids, and in the regulation of proteolytic activity. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q14520 (HABP2_HUMAN); |
Propagated annotation
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Keywords
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| Kringle | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Cross-references
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| PROSITE | PS00021; KRINGLE_1; 1; |
Features
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| From: PS50070 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Kringle #" | |||||||||
| DISULFID | 2 | 79 | disulf | C-x*-C | ||||||||
| DISULFID | 23 | 62 | disulf | C-x*-C | ||||||||
| DISULFID | 51 | 74 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 73-85 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-10 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [98] All [ 98 ]
- Retrieve set of proteins with 3D structure for this domain