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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00121


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00121
General rule information [?]

Accession PRU00121
Dates 12-DEC-2003 (Created)
20-NOV-2019 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS50070; KRINGLE_2
Name Kringle domain
Function Kringle domains are thought to play a role in binding mediators, such as membranes, other proteins or phospholipids, and in the regulation of proteolytic activity.
Scope(s) Eukaryota
Metazoa
Example(s) Q14520;

Propagated annotation [?]

Keywords [?]

Kringle
case <FTTag:disulf>
Disulfide bond
end case

Cross-references [?]

PROSITE PS00021; KRINGLE_1; 1;

Features [?]

From: PS50070
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Kringle #"
DISULFID 2 79 disulf C-x*-C
DISULFID 23 62 disulf C-x*-C
DISULFID 51 74 disulf C-x*-C

Additional information [?]

Size range 73-85 amino acids
Related rules None
Fusion None
Repeats 1-10
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]