ProRule PRU00264
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00264 |
| Accession | PRU00264 |
| Dates | 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 14) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50064; ZF_PARP_2 |
Name | Zinc finger poly(ADP-ribose) polymerase (PARP)-type |
| Function | Bind specifically to single-stranded DNA |
| Scope(s) |
Eukaryota |
| Example(s) | P35875 (PARP_DROME); |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Nucleus. |
Keywords
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| Nucleus | |
| DNA-binding | |
| Zinc-finger | |
| case <Feature:PS50064:13=[CH]> and <Feature:PS50064:16=[CH]> and <Feature:PS50064:47=[CH]> and <Feature:PS50064:50=[CH]> | |
| Zinc | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0003677; Molecular function:DNA binding |
| GO:0005634; Cellular component:nucleus |
Cross-references
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| PROSITE | PS00347; ZF_PARP_1; 1; |
Features
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| From: PS50064 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <Feature:PS50064:13=[C]> and <Feature:PS50064:16=[C]> and <Feature:PS50064:47=[H]> and <Feature:PS50064:50=[C]> | ||||||||||||
| ZN_FING | from | to | /note="PARP-type #" | |||||||||
| else case <Feature:PS50064:13=[CH]> and <Feature:PS50064:16=[CH]> and <Feature:PS50064:47=[CH]> and <Feature:PS50064:50=[CH]> | ||||||||||||
| ZN_FING | from | to | /note="PARP-type #; atypical" | |||||||||
| else | ||||||||||||
| ZN_FING | from | to | /note="PARP-type #; degenerate" | |||||||||
| end case | ||||||||||||
| BINDING | 13 | 13 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 16 | 16 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 47 | 47 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 50 | 50 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
Additional information
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| Size range | 83-93 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-2 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [20] All [ 20 ]
- Retrieve set of proteins with 3D structure for this domain