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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00267


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00267
General rule information [?]

Accession PRU00267
Dates 12-DEC-2003 (Created)
02-MAY-2025 (Last updated, Version 17)
Data class Domain;
Predictors PROSITE; PS50118; HMG_BOX_2
Name HMG boxes A and B DNA-binding domains
Function Bind preferentially to distorted DNAs
Scope(s) Eukaryota
Viruses
Example(s) Q24537;

Propagated annotation [?]

Comments [?]

case <OC:Eukaryota>
SUBCELLULAR LOCATIONNucleus.
else case <OC:Viruses>
SUBCELLULAR LOCATIONHost nucleus.
end case

Keywords [?]

case <OC:Eukaryota>
Nucleus
else case <OC:Viruses>
Host nucleus
end case
DNA-binding

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
case <OCellular component:Eukaryota>
GO:0005634; Cellular component:nucleus
else case <OCellular component:Viruses>
GO:0042025; Cellular component:host cell nucleus
end case

Cross-references [?]

PROSITE PS00353; HMG_BOX_1; 0-1;

Features [?]

From: PS50118
Key From To Description Tag Condition FTGroup
DNA_BIND from to /note="HMG box #"

Additional information [?]

Size range 44-81 amino acids
Related rules None
Fusion None
Repeats 1-6
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]