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General rule information [?]

Accession PRU00272
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 15)
Data class Domain
Predictors PROSITE; PS50830; TNASE_3
Name Thermonuclease domain
Function catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond yielding 3'-mononucleotides and dinucleotides

Propagated annotation [?]

Comments [?]

case (<OC:Bacteria> or <OC:Archaea>) and <Length<240>
Similarity Belongs to the thermonuclease family.
end case

Cross-references [?]

PROSITE PS01123; TNASE_1; 1;
PS01284; TNASE_2; 1;

Gene Ontology [?]

case <FTGroup:1>
GO:0005509; Molecular function: calcium ion binding.
end case

case <FTGroup:2>
GO:0016787; Molecular function: hydrolase activity.
end case

Keywords [?]

case <FTGroup:1>
end case

case <FTGroup:2>
end case

Features [?]

From: PS50830
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       TNase-like #        
BINDING     14     14       /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108     D   1
BINDING     33     33       /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108     D   1
BINDING     34     34       /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108     T   1
ACT_SITE     28     28             R   2
ACT_SITE     36     36             E   2
ACT_SITE     79     79             R   2

Additional information [?]

Size range 119-209 amino acids
Related rules None
Repeats 1
Topology Undefined
Examples P22997 (PARB4_ECOLX); Q7KZF4 (SND1_HUMAN): [Recover all]


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]