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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00272


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00272
General rule information [?]

Accession PRU00272
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 16)
Data class Domain;
Predictors PROSITE; PS50830; TNASE_3
Name Thermonuclease domain
Function catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond yielding 3'-mononucleotides and dinucleotides
Scope(s) Eukaryota
Bacteria
Archaea
Example(s) P22997; Q7KZF4;

Propagated annotation [?]

Comments [?]

case (<OC:Bacteria> or <OC:Archaea>) and <Length<240>
SIMILARITYBelongs to the thermonuclease family.
end case

Keywords [?]

case <FTGroup:1>
Calcium
Metal-binding
end case
case <FTGroup:2>
Hydrolase
Nuclease
Endonuclease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005509; Molecular function:calcium ion binding
end case
case <FTGroup:2>
GO:0016787; Molecular function:hydrolase activity
end case

Cross-references [?]

PROSITE PS01123; TNASE_1; 1;
PROSITE PS01284; TNASE_2; 1;

Features [?]

From: PS50830
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="TNase-like #"
BINDING 14 14 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 D 1
BINDING 33 33 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 D 1
BINDING 34 34 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 T 1
ACT_SITE 28 28 R 2
ACT_SITE 36 36 E 2
ACT_SITE 79 79 R 2

Additional information [?]

Size range 119-209 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]