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ProRule PRU00272


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU00272
Accession PRU00272
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 15)
Data class Domain;
Predictors PROSITE; PS50830; TNASE_3
Name Thermonuclease domain
Function catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond yielding 3'-mononucleotides and dinucleotides
Scope(s) Eukaryota
Bacteria
Archaea
Example(s) P22997 (PARB4_ECOLX); Q7KZF4 (SND1_HUMAN);

Propagated annotation [?]

Comments [?]

case (<OC:Bacteria> or <OC:Archaea>) and <Length<240>
SIMILARITYBelongs to the thermonuclease family.
end case

Keywords [?]

case <FTGroup:1>
Calcium
Metal-binding
end case
case <FTGroup:2>
Hydrolase
Nuclease
Endonuclease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005509; Molecular function:calcium ion binding
end case
case <FTGroup:2>
GO:0016787; Molecular function:hydrolase activity
end case

Cross-references [?]

PROSITE PS01123; TNASE_1; 1;
PROSITE PS01284; TNASE_2; 1;

Features [?]

From: PS50830
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="TNase-like #"
BINDING 14 14 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 D 1
BINDING 33 33 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 D 1
BINDING 34 34 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 T 1
ACT_SITE 28 28 R 2
ACT_SITE 36 36 E 2
ACT_SITE 79 79 R 2

Additional information [?]

Size range 119-209 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]