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annotation rule: PRU00340

General rule information [?]

Accession PRU00340
Dates 6-MAY-2004 (Created)
21-NOV-2019 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS50987; HTH_ARSR_2
Name ArsR-type HTH domain
Function The arsR-type HTH domain is a DNA-binding, winged helix-turn-helix (wHTH) domain present in transcription regulators of the arsR/smtB family, involved in stress-response to heavy metal ions. In this domain two distinct sites for metal-binding have been identified, one in helix alpha 3 and another in helix alpha 5, and other sites occur.

Propagated annotation [?]

Cross-references [?]


Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
case <FTGroup:1>
GO:0046872; Molecular function: metal ion binding.
end case

GO:0006355; Biological process: regulation of transcription, DNA-templated.
GO:0006351; Biological process: transcription, DNA-templated.

Keywords [?]

case <FTGroup:1> or <FTGroup:2>
end case

case <FTGroup:1>
end case

Features [?]

From: PS50987
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       HTH arsR-type #        
DNA_BIND     35     58       H-T-H motif        
METAL     34     34             C   1
METAL     36     36             C   1
METAL     77     77             D   2
METAL     79     79             H   2
METAL     90     90             H   2
METAL     93     93             [EH]   2

Additional information [?]

Size range 68-110 amino acids
Related rules None
Repeats 1
Topology Cytoplasmic
Example P30340 (SMTB_SYNE7)


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UniProtKB rule member sequences [?]