PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00340


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00340
General rule information [?]

Accession PRU00340
Dates 06-MAY-2004 (Created)
19-NOV-2022 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS50987; HTH_ARSR_2
Name ArsR-type HTH domain
Function The arsR-type HTH domain is a DNA-binding, winged helix-turn-helix (wHTH) domain present in transcription regulators of the arsR/smtB family, involved in stress-response to heavy metal ions. In this domain two distinct sites for metal-binding have been identified, one in helix alpha 3 and another in helix alpha 5, and other sites occur.
Scope(s) Bacteria
Archaea
Example(s) P30340;

Propagated annotation [?]

Keywords [?]

DNA-binding
case <FTGroup:1> or <FTGroup:2>
Metal-binding
end case
case <FTGroup:1>
Metal-thiolate cluster
end case
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
case <FTGroup:1>
GO:0046872; Molecular function:metal ion binding
end case
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Cross-references [?]

PROSITE PS00846; HTH_ARSR_1; 1;

Features [?]

From: PS50987
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="HTH arsR-type #"
DNA_BIND 35 58 /note="H-T-H motif"
BINDING 34 34 /ligand="a metal cation"
/ligand_id="ChEBI:CHEBI:25213"
/ligand_label="#1"		 C 1
BINDING 36 36 /ligand="a metal cation"
/ligand_id="ChEBI:CHEBI:25213"
/ligand_label="#1"		 C 1
BINDING 77 77 /ligand="a metal cation"
/ligand_id="ChEBI:CHEBI:25213"
/ligand_label="#2"		 D 2
BINDING 79 79 /ligand="a metal cation"
/ligand_id="ChEBI:CHEBI:25213"
/ligand_label="#2"		 H 2
BINDING 90 90 /ligand="a metal cation"
/ligand_id="ChEBI:CHEBI:25213"
/ligand_label="#2"		 H 2
BINDING 93 93 /ligand="a metal cation"
/ligand_id="ChEBI:CHEBI:25213"
/ligand_label="#2"		 [EH] 2

Additional information [?]

Size range 68-110 amino acids
Related rules None
Fusion None
Repeats 1
Topology Cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]