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ProRule PRU00340


General rule information [?]

Accession PRU00340
Dates 6-MAY-2004 (Created)
19-NOV-2022 (Last updated, Version 12)
Data class Domain;
Predictors PROSITE; PS50987; HTH_ARSR_2
Name ArsR-type HTH domain
Function The arsR-type HTH domain is a DNA-binding, winged helix-turn-helix (wHTH) domain present in transcription regulators of the arsR/smtB family, involved in stress-response to heavy metal ions. In this domain two distinct sites for metal-binding have been identified, one in helix alpha 3 and another in helix alpha 5, and other sites occur.
Scope(s) Bacteria
Archaea
Example(s) P30340 (SMTB_SYNE7);

Propagated annotation [?]

Keywords [?]

DNA-binding
case <FTGroup:1> or <FTGroup:2>
Metal-binding
end case
case <FTGroup:1>
Metal-thiolate cluster
end case
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
case <FTGroup:1>
GO:0046872; Molecular function:metal ion binding
end case
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Cross-references [?]

PROSITE PS00846; HTH_ARSR_1; 1;

Features [?]

From: PS50987
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="HTH arsR-type #"
DNA_BIND 35 58 /note="H-T-H motif"
BINDING 34 34 /ligand="a metal cation"
/ligand_id="ChEBI:CHEBI:25213"
/ligand_label="#1"		 C 1
BINDING 36 36 /ligand="a metal cation"
/ligand_id="ChEBI:CHEBI:25213"
/ligand_label="#1"		 C 1
BINDING 77 77 /ligand="a metal cation"
/ligand_id="ChEBI:CHEBI:25213"
/ligand_label="#2"		 D 2
BINDING 79 79 /ligand="a metal cation"
/ligand_id="ChEBI:CHEBI:25213"
/ligand_label="#2"		 H 2
BINDING 90 90 /ligand="a metal cation"
/ligand_id="ChEBI:CHEBI:25213"
/ligand_label="#2"		 H 2
BINDING 93 93 /ligand="a metal cation"
/ligand_id="ChEBI:CHEBI:25213"
/ligand_label="#2"		 [EH] 2

Additional information [?]

Size range 68-110 amino acids
Related rules None
Fusion None
Repeats 1
Topology Cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]