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General rule information [?]

Accession PRU00340
Dates 6-MAY-2004 (Created)
19-NOV-2022 (Last updated, Version 12)
Data class Domain
Predictors PROSITE; PS50987; HTH_ARSR_2
Name ArsR-type HTH domain
Function The arsR-type HTH domain is a DNA-binding, winged helix-turn-helix (wHTH) domain present in transcription regulators of the arsR/smtB family, involved in stress-response to heavy metal ions. In this domain two distinct sites for metal-binding have been identified, one in helix alpha 3 and another in helix alpha 5, and other sites occur.

Propagated annotation [?]

Cross-references [?]


Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
case <FTGroup:1>
GO:0046872; Molecular function: metal ion binding.
end case

GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0006351; Biological process: DNA-templated transcription.

Keywords [?]

case <FTGroup:1> or <FTGroup:2>
end case

case <FTGroup:1>
end case

Features [?]

From: PS50987
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       HTH arsR-type #        
DNA_BIND     35     58       H-T-H motif        
BINDING     34     34       /ligand="a metal cation" /ligand_id="ChEBI:CHEBI:25213" /ligand_label="#1     C   1
BINDING     36     36       /ligand="a metal cation" /ligand_id="ChEBI:CHEBI:25213" /ligand_label="#1     C   1
BINDING     77     77       /ligand="a metal cation" /ligand_id="ChEBI:CHEBI:25213" /ligand_label="#2     D   2
BINDING     79     79       /ligand="a metal cation" /ligand_id="ChEBI:CHEBI:25213" /ligand_label="#2     H   2
BINDING     90     90       /ligand="a metal cation" /ligand_id="ChEBI:CHEBI:25213" /ligand_label="#2     H   2
BINDING     93     93       /ligand="a metal cation" /ligand_id="ChEBI:CHEBI:25213" /ligand_label="#2     [EH]   2

Additional information [?]

Warning Replace "Metal cation" by the corresponding metal if it is known.
Size range 68-110 amino acids
Related rules None
Repeats 1
Topology Cytoplasmic
Example P30340 (SMTB_SYNE7)


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]