PRU00381

General rule information [?]

Accession	PRU00381
Dates	6-JAN-2005 (Created) 27-JUN-2022 (Last updated, Version 12)

Data class

Domain

Predictors

PROSITE; PS51057; PAIRED_2

Name	Paired DNA-binding domain

Function

The paired domain is a ~126 amino acid DNA-binding domain, which is found in eukaryotic transcription regulatory proteins involved in embryogenesis.

Propagated annotation [?]

Comments [?]

Subcellular location

Nucleus.

Cross-references [?]

PROSITE

PS00034; PAIRED_1; 1;

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0005634; Cellular component: nucleus.
GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0006351; Biological process: DNA-templated transcription.

Keywords [?]

DNA-binding
Nucleus
Paired box
Transcription
Transcription regulation

Features [?]

From: PS51057

Key From To Description Tag Condition FTGroup

DNA_BIND from to Paired #

REGION 4 60 PAI subdomain #

REGION 79 to RED subdomain #

Additional information [?]

Size range	120-140 amino acids
Related rules	None
Repeats	1
Topology	Not cytoplasmic
Example	P63016 (PAX6_RAT)
Scope	Eukaryota; Metazoa

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Eukaryota [63]
Retrieve set of proteins with 3D structure for this domain