ProRule PRU00381
General rule information
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| Accession | PRU00381 |
| Dates | 6-JAN-2005 (Created)
27-JUN-2022 (Last updated, Version 12) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51057; PAIRED_2 |
Name | Paired DNA-binding domain |
| Function | The paired domain is a ~126 amino acid DNA-binding domain, which is found in eukaryotic transcription regulatory proteins involved in embryogenesis. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | P63016 (PAX6_RAT); |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Nucleus. |
Keywords
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Gene Ontology
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| GO:0003677; Molecular function:DNA binding |
| GO:0005634; Cellular component:nucleus |
| GO:0006355; Biological process:regulation of DNA-templated transcription |
| GO:0006351; Biological process:DNA-templated transcription |
Cross-references
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| PROSITE | PS00034; PAIRED_1; 1; |
Features
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| From: PS51057 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DNA_BIND | from | to | /note="Paired #" | |||||||||
| REGION | 4 | 60 | /note="PAI subdomain #" | |||||||||
| REGION | 79 | to | /note="RED subdomain #" | |||||||||
Additional information
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| Size range | 120-140 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Not cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [63] All [ 63 ]
- Retrieve set of proteins with 3D structure for this domain