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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00381


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00381
General rule information [?]

Accession PRU00381
Dates 06-JAN-2005 (Created)
27-JUN-2022 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS51057; PAIRED_2
Name Paired DNA-binding domain
Function The paired domain is a ~126 amino acid DNA-binding domain, which is found in eukaryotic transcription regulatory proteins involved in embryogenesis.
Scope(s) Eukaryota
Metazoa
Example(s) P63016;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.

Keywords [?]

DNA-binding
Nucleus
Paired box
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0005634; Cellular component:nucleus
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Cross-references [?]

PROSITE PS00034; PAIRED_1; 1;

Features [?]

From: PS51057
Key From To Description Tag Condition FTGroup
DNA_BIND from to /note="Paired #"
REGION 4 60 /note="PAI subdomain #"
REGION 79 to /note="RED subdomain #"

Additional information [?]

Size range 120-140 amino acids
Related rules None
Fusion None
Repeats 1
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]