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annotation rule: PRU00381

General rule information [?]

Accession PRU00381
Dates 6-JAN-2005 (Created)
21-JUN-2019 (Last updated, Version 10)
Data class Domain
Predictors PROSITE; PS51057; PAIRED_2
Name Paired DNA-binding domain
Function The paired domain is a ~126 amino acid DNA-binding domain, which is found in eukaryotic transcription regulatory proteins involved in embryogenesis.

Propagated annotation [?]


Comments [?]

Subcellular location Nucleus.

Cross-references [?]

PROSITE PS00034; PAIRED_1; 1;

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0005634; Cellular component: nucleus.
GO:0006355; Biological process: regulation of transcription, DNA-templated.
GO:0006351; Biological process: transcription, DNA-templated.

Keywords [?]


Features [?]

From: PS51057
Key     From     To       Description   Tag   Condition   FTGroup
DNA_BIND     from     to       Paired #        
REGION     4     60       PAI subdomain #        
REGION     79     to       RED subdomain #        

Additional information [?]

Size range 120-140 amino acids
Related rules None
Repeats 1
Topology Not cytoplasmic
Example P63016 (PAX6_RAT)
Scope
Eukaryota; Metazoa

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]