We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00540
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00540
General rule information
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| Accession | PRU00540 |
| Dates | 11-APR-2006 (Created)
19-NOV-2022 (Last updated, Version 16) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51197; HTH_RRF2_2 |
Name | Rrf2-type HTH domain |
| Function | The rrf2-type HTH domain is a putative DNA-binding, winged helix-turn-helix (wHTH) domain of about 130 residues present in transcription regulators of the rrf2 family, involved in nitrite or iron metabolism. The C-terminal part of the domain contains 3 conserved cysteine residues that may bind an Fe-S cluster. |
| Scope(s) |
Bacteria |
| Example(s) | P0AGK8; |
Propagated annotation
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Keywords
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| DNA-binding | |
| case <FTGroup:1> | |
| Metal-binding | |
| end case | |
| Transcription | |
| Transcription regulation | |
Gene Ontology
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| GO:0003677; Molecular function:DNA binding | |
| case <FTGroup:1> | |
| GO:0046872; Molecular function:metal ion binding | |
| end case | |
| GO:0006355; Biological process:regulation of DNA-templated transcription | |
| GO:0006351; Biological process:DNA-templated transcription | |
Cross-references
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| PROSITE | PS01332; HTH_RRF2_1; 1; |
Features
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| From: PS51197 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="HTH rrf2-type #" | |||||||||
| DNA_BIND | 26 | 49 | /note="H-T-H motif" | |||||||||
| BINDING | 90 | 90 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
| BINDING | 96 | 96 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
| BINDING | 102 | 102 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
Additional information
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| Size range | 120-150 amino acids |
| Related rules |
PRU00393 PRU00307 |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [158] All [ 158 ]
- Retrieve set of proteins with 3D structure for this domain