PRU00540

General rule information [?]

Accession	PRU00540
Dates	11-APR-2006 (Created) 19-NOV-2022 (Last updated, Version 15)

Data class

Domain

Predictors

PROSITE; PS51197; HTH_RRF2_2

Name	Rrf2-type HTH domain

Function

The rrf2-type HTH domain is a putative DNA-binding, winged helix-turn-helix (wHTH) domain of about 130 residues present in transcription regulators of the rrf2 family, involved in nitrite or iron metabolism. The C-terminal part of the domain contains 3 conserved cysteine residues that may bind an Fe-S cluster.

Propagated annotation [?]

Cross-references [?]

PROSITE

PS01332; HTH_RRF2_1; 1;

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.

case <FTGroup:1>

GO:0046872; Molecular function: metal ion binding.

end case

GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0006351; Biological process: DNA-templated transcription.

Keywords [?]

DNA-binding

case <FTGroup:1>

Metal-binding

end case

Transcription
Transcription regulation

Features [?]

From: PS51197

Key From To Description Tag Condition FTGroup

DOMAIN from to HTH rrf2-type #

DNA_BIND 26 49 H-T-H motif

BINDING 90 90 /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135 C 1

BINDING 96 96 /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135 C 1

BINDING 102 102 /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135 C 1

Additional information [?]

Size range	120-150 amino acids
Related rules	PRU00393; PRU00307
Repeats	1
Topology	Undefined
Example	P0AGK8 (ISCR_ECOLI)
Scope	Bacteria

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UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Bacteria [157]
Retrieve set of proteins with 3D structure for this domain