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General rule information [?]

Accession PRU00540
Dates 11-APR-2006 (Created)
19-NOV-2022 (Last updated, Version 15)
Data class Domain
Predictors PROSITE; PS51197; HTH_RRF2_2
Name Rrf2-type HTH domain
Function The rrf2-type HTH domain is a putative DNA-binding, winged helix-turn-helix (wHTH) domain of about 130 residues present in transcription regulators of the rrf2 family, involved in nitrite or iron metabolism. The C-terminal part of the domain contains 3 conserved cysteine residues that may bind an Fe-S cluster.

Propagated annotation [?]

Cross-references [?]

PROSITE PS01332; HTH_RRF2_1; 1;

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
case <FTGroup:1>
GO:0046872; Molecular function: metal ion binding.
end case

GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0006351; Biological process: DNA-templated transcription.

Keywords [?]

case <FTGroup:1>
end case

Features [?]

From: PS51197
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       HTH rrf2-type #        
DNA_BIND     26     49       H-T-H motif        
BINDING     90     90       /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135     C   1
BINDING     96     96       /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135     C   1
BINDING     102     102       /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135     C   1

Additional information [?]

Size range 120-150 amino acids
Related rules PRU00393; PRU00307
Repeats 1
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]