ProRule PRU00540
General rule information
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Accession | PRU00540 |
Dates | 11-APR-2006 (Created)
19-NOV-2022 (Last updated, Version 15) |
Data class | Domain; |
Predictors |
PROSITE; PS51197; HTH_RRF2_2 |
Name | Rrf2-type HTH domain |
Function | The rrf2-type HTH domain is a putative DNA-binding, winged helix-turn-helix (wHTH) domain of about 130 residues present in transcription regulators of the rrf2 family, involved in nitrite or iron metabolism. The C-terminal part of the domain contains 3 conserved cysteine residues that may bind an Fe-S cluster. |
Scope(s) |
Bacteria |
Example(s) | P0AGK8 (ISCR_ECOLI); |
Propagated annotation
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Keywords
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DNA-binding | |
case <FTGroup:1> | |
Metal-binding | |
end case | |
Transcription | |
Transcription regulation |
Gene Ontology
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GO:0003677; Molecular function:DNA binding | |
case <FTGroup:1> | |
GO:0046872; Molecular function:metal ion binding | |
end case | |
GO:0006355; Biological process:regulation of DNA-templated transcription | |
GO:0006351; Biological process:DNA-templated transcription |
Cross-references
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PROSITE | PS01332; HTH_RRF2_1; 1; |
Features
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From: PS51197 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="HTH rrf2-type #" | |||||||||
DNA_BIND | 26 | 49 | /note="H-T-H motif" | |||||||||
BINDING | 90 | 90 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
BINDING | 96 | 96 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
BINDING | 102 | 102 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 |
Additional information
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Size range | 120-150 amino acids |
Related rules |
PRU00393 PRU00307 |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [158] All [ 158 ]
- Retrieve set of proteins with 3D structure for this domain