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annotation rule: PRU00540

General rule information [?]

Accession PRU00540
Dates 11-APR-2006 (Created)
21-NOV-2019 (Last updated, Version 11)
Data class Domain
Predictors PROSITE; PS51197; HTH_RRF2_2
Name Rrf2-type HTH domain
Function The rrf2-type HTH domain is a putative DNA-binding, winged helix-turn-helix (wHTH) domain of about 130 residues present in transcription regulators of the rrf2 family, involved in nitrite or iron metabolism. The C-terminal part of the domain contains 3 conserved cysteine residues that may bind an Fe-S cluster.

Propagated annotation [?]


Cross-references [?]

PROSITE PS01332; HTH_RRF2_1; 1;

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
case <FTGroup:1>
GO:0046872; Molecular function: metal ion binding.
end case

GO:0006355; Biological process: regulation of transcription, DNA-templated.
GO:0006351; Biological process: transcription, DNA-templated.

Keywords [?]

DNA-binding
case <FTGroup:1>
Metal-binding
end case

Transcription
Transcription regulation

Features [?]

From: PS51197
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       HTH rrf2-type #        
DNA_BIND     26     49       H-T-H motif        
METAL     90     90             C   1
METAL     96     96             C   1
METAL     102     102             C   1

Additional information [?]

Size range 120-150 amino acids
Related rules PRU00393; PRU00307
Repeats 1
Topology Undefined
Example P0AGK8 (ISCR_ECOLI)
Scope
Bacteria

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]