ProRule PRU00540

General rule information [?]

Accession PRU00540
Dates 11-APR-2006 (Created)
19-NOV-2022 (Last updated, Version 15)
Data class Domain;
Predictors PROSITE; PS51197; HTH_RRF2_2
Name Rrf2-type HTH domain
Function The rrf2-type HTH domain is a putative DNA-binding, winged helix-turn-helix (wHTH) domain of about 130 residues present in transcription regulators of the rrf2 family, involved in nitrite or iron metabolism. The C-terminal part of the domain contains 3 conserved cysteine residues that may bind an Fe-S cluster.
Scope(s) Bacteria
Example(s) P0AGK8 (ISCR_ECOLI);

Propagated annotation [?]

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
case <FTGroup:1>
GO:0046872; Molecular function:metal ion binding
end case
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Cross-references [?]

PROSITE PS01332; HTH_RRF2_1; 1;

Features [?]

From: PS51197
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="HTH rrf2-type #"
DNA_BIND 26 49 /note="H-T-H motif"
BINDING 90 90 /ligand="[2Fe-2S] cluster"
C 1
BINDING 96 96 /ligand="[2Fe-2S] cluster"
C 1
BINDING 102 102 /ligand="[2Fe-2S] cluster"
C 1

Additional information [?]

Size range 120-150 amino acids
Related rules PRU00393
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]