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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00593


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00593
General rule information [?]

Accession PRU00593
Dates 17-OCT-2006 (Created)
27-JUN-2022 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS01124; HTH_ARAC_FAMILY_2
Name araC/xylS-type HTH domain
Function The araC/xylS-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 100 amino acids, present in bacterial transcription regulators of genes involved in resistance to antibiotics, organic solvents and heavy metals.
Scope(s) Eukaryota
Bacteria
Example(s) P0ACH5;

Propagated annotation [?]

Keywords [?]

DNA-binding
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Cross-references [?]

PROSITE PS00041; HTH_ARAC_FAMILY_1; 1;

Features [?]

From: PS01124
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="HTH araC/xylS-type #"
DNA_BIND 18 39 /note="H-T-H motif"
DNA_BIND 66 89 /note="H-T-H motif"

Additional information [?]

Size range 80-120 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]