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annotation rule: PRU00741

General rule information [?]

Accession PRU00741
Dates 17-DEC-2008 (Created)
16-DEC-2016 (Last updated, Version 9)
Data class Domain
Predictors PROSITE; PS51408; TRANSFERRIN_LIKE_4
Name Transferrin-like domain
Function The transferrin family is a group of glycosylated proteins found in both vertebrates and invertebrates. Most family members contain two transferrin-like domains of around 340 amino acids, the result of an ancient duplication event.

Propagated annotation [?]


Description [?]

case <FTGroup:1>
+ RecName: EC=3.4.21.-;
end case


Comments [?]

Similarity Belongs to the transferrin family.

Cross-references [?]

case <FTGroup:1>
PROSITE PS00205; TRANSFERRIN_LIKE_1; 1;
PS00206; TRANSFERRIN_LIKE_2; 1;
PS00207; TRANSFERRIN_LIKE_3; 1;
end case


Gene Ontology [?]

case <FTGroup:1>
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0004252; Molecular function: serine-type endopeptidase activity.
end case

case <FTGroup:2>
GO:0005506; Molecular function: iron ion binding.
GO:0046872; Molecular function: metal ion binding.
end case


Keywords [?]

case <FTGroup:1>
end case

case <FTGroup:2>
end case

case <FTTag:disulf>
end case


Features [?]

From: PS51408
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Transferrin-like #        
ACT_SITE     68     68             K   1
ACT_SITE     256     256       Nucleophile     S   1
METAL     56     56       Iron #1     D   2
METAL     85     85       Iron #1     Y   2
METAL     184     184       Iron #1     Y   2
METAL     249     249       Iron #1     H   2
BINDING     111     111       Carbonate #1     T   2
BINDING     115     115       Carbonate #1     R   2
BINDING     117     117       Carbonate #1; via amide nitrogen     A   2
BINDING     118     118       Carbonate #1; via amide nitrogen     G   2
DISULFID     4     41           disulf   C-x*-C  
DISULFID     14     32           disulf   C-x*-C  
DISULFID     109     190           disulf   C-x*-C  
DISULFID     151     169           disulf   C-x*-C  
DISULFID     154     175           disulf   C-x*-C  
DISULFID     166     173           disulf   C-x*-C  
DISULFID     227     241           disulf   C-x*-C  

Additional information [?]

Size range 245-610 amino acids
Related rules None
Repeats 1-2
Topology Not cytoplasmic
Example P02788 (TRFL_HUMAN)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.



UniProtKB rule member sequences [?]