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ProRule PRU00741
General rule information
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Accession | PRU00741 |
Dates | 17-DEC-2008 (Created)
19-NOV-2022 (Last updated, Version 13) |
Data class | Domain; |
Predictors |
PROSITE; PS51408; TRANSFERRIN_LIKE_4 |
Name | Transferrin-like domain |
Function | The transferrin family is a group of glycosylated proteins found in both vertebrates and invertebrates. Most family members contain two transferrin-like domains of around 340 amino acids, the result of an ancient duplication event. |
Scope(s) |
Eukaryota |
Example(s) | P02788 (TRFL_HUMAN); |
Propagated annotation
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Identifier, protein and gene names
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case <FTGroup:1> | |
Protein name | + RecName: EC=3.4.21.-; |
end case |
Comments
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SIMILARITY | Belongs to the transferrin family. |
Keywords
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case <FTGroup:1> | |
Hydrolase | |
Protease | |
Serine protease | |
end case | |
case <FTGroup:2> | |
Iron | |
Metal-binding | |
end case | |
case <FTTag:disulf> | |
Disulfide bond | |
end case |
Gene Ontology
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case <FTGroup:1> | |
GO:0016787; Molecular function:hydrolase activity | |
GO:0008233; Molecular function:peptidase activity | |
GO:0004252; Molecular function:serine-type endopeptidase activity | |
end case | |
case <FTGroup:2> | |
GO:0005506; Molecular function:iron ion binding | |
GO:0046872; Molecular function:metal ion binding | |
end case |
Cross-references
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PROSITE | PS00205; TRANSFERRIN_LIKE_1; 1; |
PROSITE | PS00206; TRANSFERRIN_LIKE_2; 1; |
PROSITE | PS00207; TRANSFERRIN_LIKE_3; 1; |
Features
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From: PS51408 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="Transferrin-like #" | |||||||||
ACT_SITE | 68 | 68 | K | 1 | ||||||||
ACT_SITE | 256 | 256 | /note="Nucleophile" | S | 1 | |||||||
BINDING | 56 | 56 | /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034" /ligand_label="#1" |
D | 2 | |||||||
BINDING | 85 | 85 | /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034" /ligand_label="#1" |
Y | 2 | |||||||
BINDING | 184 | 184 | /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034" /ligand_label="#1" |
Y | 2 | |||||||
BINDING | 249 | 249 | /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034" /ligand_label="#1" |
H | 2 | |||||||
BINDING | 111 | 111 | /ligand="hydrogencarbonate" /ligand_id="ChEBI:CHEBI:17544" /ligand_label="#1" |
T | 2 | |||||||
BINDING | 115 | 115 | /ligand="hydrogencarbonate" /ligand_id="ChEBI:CHEBI:17544" /ligand_label="#1" |
R | 2 | |||||||
BINDING | 117 | 117 | /ligand="hydrogencarbonate" /ligand_id="ChEBI:CHEBI:17544" /ligand_label="#1" |
A | 2 | |||||||
BINDING | 118 | 118 | /ligand="hydrogencarbonate" /ligand_id="ChEBI:CHEBI:17544" /ligand_label="#1" |
G | 2 | |||||||
DISULFID | 4 | 41 | disulf | C-x*-C | ||||||||
DISULFID | 14 | 32 | disulf | C-x*-C | ||||||||
DISULFID | 109 | 190 | disulf | C-x*-C | ||||||||
DISULFID | 151 | 169 | disulf | C-x*-C | ||||||||
DISULFID | 154 | 175 | disulf | C-x*-C | ||||||||
DISULFID | 166 | 173 | disulf | C-x*-C | ||||||||
DISULFID | 227 | 241 | disulf | C-x*-C |
Additional information
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Size range | 245-610 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1-2 |
Topology | Not cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [42] All [ 42 ]
- Retrieve set of proteins with 3D structure for this domain