PROSITE logo

ProRule logo
PRU00741


General rule information [?]

Accession PRU00741
Dates 17-DEC-2008 (Created)
19-NOV-2022 (Last updated, Version 13)
Data class Domain
Predictors PROSITE; PS51408; TRANSFERRIN_LIKE_4
Name Transferrin-like domain
Function The transferrin family is a group of glycosylated proteins found in both vertebrates and invertebrates. Most family members contain two transferrin-like domains of around 340 amino acids, the result of an ancient duplication event.

Propagated annotation [?]


Description [?]

case <FTGroup:1>
+ RecName: EC 3.4.21.-;
end case


Comments [?]

Similarity Belongs to the transferrin family.

Cross-references [?]

case <FTGroup:1>
PROSITE PS00205; TRANSFERRIN_LIKE_1; 1;
PS00206; TRANSFERRIN_LIKE_2; 1;
PS00207; TRANSFERRIN_LIKE_3; 1;
end case


Gene Ontology [?]

case <FTGroup:1>
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0004252; Molecular function: serine-type endopeptidase activity.
end case

case <FTGroup:2>
GO:0005506; Molecular function: iron ion binding.
GO:0046872; Molecular function: metal ion binding.
end case


Keywords [?]

case <FTGroup:1>
end case

case <FTGroup:2>
end case

case <FTTag:disulf>
end case


Features [?]

From: PS51408
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Transferrin-like #        
ACT_SITE     68     68             K   1
ACT_SITE     256     256       Nucleophile     S   1
BINDING     56     56       /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034" /ligand_label="#1     D   2
BINDING     85     85       /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034" /ligand_label="#1     Y   2
BINDING     184     184       /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034" /ligand_label="#1     Y   2
BINDING     249     249       /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034" /ligand_label="#1     H   2
BINDING     111     111       /ligand="hydrogencarbonate" /ligand_id="ChEBI:CHEBI:17544" /ligand_label="#1     T   2
BINDING     115     115       /ligand="hydrogencarbonate" /ligand_id="ChEBI:CHEBI:17544" /ligand_label="#1     R   2
BINDING     117     117       /ligand="hydrogencarbonate" /ligand_id="ChEBI:CHEBI:17544" /ligand_label="#1     A   2
BINDING     118     118       /ligand="hydrogencarbonate" /ligand_id="ChEBI:CHEBI:17544" /ligand_label="#1     G   2
DISULFID     4     41           disulf   C-x*-C  
DISULFID     14     32           disulf   C-x*-C  
DISULFID     109     190           disulf   C-x*-C  
DISULFID     151     169           disulf   C-x*-C  
DISULFID     154     175           disulf   C-x*-C  
DISULFID     166     173           disulf   C-x*-C  
DISULFID     227     241           disulf   C-x*-C  

Additional information [?]

Size range 245-610 amino acids
Related rules None
Repeats 1-2
Topology Not cytoplasmic
Example P02788 (TRFL_HUMAN)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]