PROSITE logo

ProRule PRU00741


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU00741
Accession PRU00741
Dates 17-DEC-2008 (Created)
19-NOV-2022 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS51408; TRANSFERRIN_LIKE_4
Name Transferrin-like domain
Function The transferrin family is a group of glycosylated proteins found in both vertebrates and invertebrates. Most family members contain two transferrin-like domains of around 340 amino acids, the result of an ancient duplication event.
Scope(s) Eukaryota
Example(s) P02788 (TRFL_HUMAN);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=3.4.21.-;
end case

Comments [?]

SIMILARITYBelongs to the transferrin family.

Keywords [?]

case <FTGroup:1>
Hydrolase
Protease
Serine protease
end case
case <FTGroup:2>
Iron
Metal-binding
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0016787; Molecular function:hydrolase activity
GO:0008233; Molecular function:peptidase activity
GO:0004252; Molecular function:serine-type endopeptidase activity
end case
case <FTGroup:2>
GO:0005506; Molecular function:iron ion binding
GO:0046872; Molecular function:metal ion binding
end case

Cross-references [?]

PROSITE PS00205; TRANSFERRIN_LIKE_1; 1;
PROSITE PS00206; TRANSFERRIN_LIKE_2; 1;
PROSITE PS00207; TRANSFERRIN_LIKE_3; 1;

Features [?]

From: PS51408
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Transferrin-like #"
ACT_SITE 68 68 K 1
ACT_SITE 256 256 /note="Nucleophile" S 1
BINDING 56 56 /ligand="Fe(3+)"
/ligand_id="ChEBI:CHEBI:29034"
/ligand_label="#1"		 D 2
BINDING 85 85 /ligand="Fe(3+)"
/ligand_id="ChEBI:CHEBI:29034"
/ligand_label="#1"		 Y 2
BINDING 184 184 /ligand="Fe(3+)"
/ligand_id="ChEBI:CHEBI:29034"
/ligand_label="#1"		 Y 2
BINDING 249 249 /ligand="Fe(3+)"
/ligand_id="ChEBI:CHEBI:29034"
/ligand_label="#1"		 H 2
BINDING 111 111 /ligand="hydrogencarbonate"
/ligand_id="ChEBI:CHEBI:17544"
/ligand_label="#1"		 T 2
BINDING 115 115 /ligand="hydrogencarbonate"
/ligand_id="ChEBI:CHEBI:17544"
/ligand_label="#1"		 R 2
BINDING 117 117 /ligand="hydrogencarbonate"
/ligand_id="ChEBI:CHEBI:17544"
/ligand_label="#1"		 A 2
BINDING 118 118 /ligand="hydrogencarbonate"
/ligand_id="ChEBI:CHEBI:17544"
/ligand_label="#1"		 G 2
DISULFID 4 41 disulf C-x*-C
DISULFID 14 32 disulf C-x*-C
DISULFID 109 190 disulf C-x*-C
DISULFID 151 169 disulf C-x*-C
DISULFID 154 175 disulf C-x*-C
DISULFID 166 173 disulf C-x*-C
DISULFID 227 241 disulf C-x*-C

Additional information [?]

Size range 245-610 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



View rule in raw text format (no links)

UniProtKB rule member sequences [?]