PRU00741

General rule information [?]

Accession	PRU00741
Dates	17-DEC-2008 (Created) 19-NOV-2022 (Last updated, Version 13)

Data class

Domain

Predictors

PROSITE; PS51408; TRANSFERRIN_LIKE_4

Name	Transferrin-like domain

Function

The transferrin family is a group of glycosylated proteins found in both vertebrates and invertebrates. Most family members contain two transferrin-like domains of around 340 amino acids, the result of an ancient duplication event.

Propagated annotation [?]

Description [?]

case <FTGroup:1>

+ RecName: EC 3.4.21.-;

end case

Comments [?]

Similarity

Belongs to the transferrin family.

Cross-references [?]

case <FTGroup:1>

PROSITE	PS00205; TRANSFERRIN_LIKE_1; 1;
	PS00206; TRANSFERRIN_LIKE_2; 1;
	PS00207; TRANSFERRIN_LIKE_3; 1;

end case

Gene Ontology [?]

case <FTGroup:1>

GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0004252; Molecular function: serine-type endopeptidase activity.

end case

case <FTGroup:2>

GO:0005506; Molecular function: iron ion binding.
GO:0046872; Molecular function: metal ion binding.

end case

Keywords [?]

case <FTGroup:1>

Hydrolase
Protease
Serine protease

end case

case <FTGroup:2>

Iron
Metal-binding

end case

case <FTTag:disulf>

Disulfide bond

end case

Features [?]

From: PS51408

Key From To Description Tag Condition FTGroup

DOMAIN from to Transferrin-like #

ACT_SITE 68 68 K 1

ACT_SITE 256 256 Nucleophile S 1

BINDING 56 56 /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034" /ligand_label="#1 D 2

BINDING 85 85 /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034" /ligand_label="#1 Y 2

BINDING 184 184 /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034" /ligand_label="#1 Y 2

BINDING 249 249 /ligand="Fe(3+)" /ligand_id="ChEBI:CHEBI:29034" /ligand_label="#1 H 2

BINDING 111 111 /ligand="hydrogencarbonate" /ligand_id="ChEBI:CHEBI:17544" /ligand_label="#1 T 2

BINDING 115 115 /ligand="hydrogencarbonate" /ligand_id="ChEBI:CHEBI:17544" /ligand_label="#1 R 2

BINDING 117 117 /ligand="hydrogencarbonate" /ligand_id="ChEBI:CHEBI:17544" /ligand_label="#1 A 2

BINDING 118 118 /ligand="hydrogencarbonate" /ligand_id="ChEBI:CHEBI:17544" /ligand_label="#1 G 2

DISULFID 4 41 disulf C-x*-C

DISULFID 14 32 disulf C-x*-C

DISULFID 109 190 disulf C-x*-C

DISULFID 151 169 disulf C-x*-C

DISULFID 154 175 disulf C-x*-C

DISULFID 166 173 disulf C-x*-C

DISULFID 227 241 disulf C-x*-C

Additional information [?]

Size range	245-610 amino acids
Related rules	None
Repeats	1-2
Topology	Not cytoplasmic
Example	P02788 (TRFL_HUMAN)
Scope	Eukaryota
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Eukaryota [41]
Retrieve set of proteins with 3D structure for this domain