ProRule PRU00742
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00742 |
| Accession | PRU00742 |
| Dates | 25-NOV-2008 (Created)
19-NOV-2022 (Last updated, Version 8) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51409; ARGINASE_2 |
Name | Arginase family |
| Function | Arginase family proteins are ureohydrolases with important roles in arginine/agmatine metabolism, the urea cycle, histidine degradation, and other pathways. The family includes arginase and related enzymes of ~300 amino acids that typically contain two manganese ions in the active site. |
| Scope(s) |
Eukaryota Bacteria Archaea |
| Example(s) | Q9HQD7 (HUTG_HALSA); P46637 (ARGI1_ARATH); |
Propagated annotation
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Identifier, protein and gene names
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| case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D> | |
| Protein name | + RecName: EC=3.5.3.-; |
| end case | |
Comments
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| case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D> | |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.; |
| else case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D> | |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| end case | |
| SIMILARITY | Belongs to the arginase family. |
Keywords
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| Hydrolase | |
| Manganese | |
| Metal-binding | |
| end case | |
Gene Ontology
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| case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D> | |
| GO:0016787; Molecular function:hydrolase activity | |
| GO:0030145; Molecular function:manganese ion binding | |
| GO:0046872; Molecular function:metal ion binding | |
Cross-references
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| PROSITE | PS01053; ARGINASE_1; 1; |
Features
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| From: PS51409 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 96 | 96 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1" |
[HN] | ||||||||
| BINDING | 120 | 120 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1" |
D | ||||||||
| BINDING | 120 | 120 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2" |
D | ||||||||
| BINDING | 122 | 122 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2" |
H | ||||||||
| BINDING | 124 | 124 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1" |
D | ||||||||
| BINDING | 213 | 213 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1" |
[DC] | ||||||||
| BINDING | 213 | 213 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2" |
[DC] | ||||||||
| BINDING | 215 | 215 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2" |
D | ||||||||
Additional information
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| Size range | 260-350 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [6] Bacteria [180] Eukaryota [43] All [ 229 ]
- Retrieve set of proteins with 3D structure for this domain