PRU00742
General rule information
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Accession | PRU00742 |
Dates | 25-NOV-2008 (Created) 19-NOV-2022 (Last updated, Version 8) |
Data class | Domain |
Predictors | PROSITE; PS51409; ARGINASE_2 |
Names | Arginase family; ureohydrolase superfamily |
Function | Arginase family proteins are ureohydrolases with important roles in arginine/agmatine metabolism, the urea cycle, histidine degradation, and other pathways. The family includes arginase and related enzymes of ~300 amino acids that typically contain two manganese ions in the active site. |
Propagated annotation
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Description
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case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
+ RecName: EC 3.5.3.-; |
end case
Comments
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case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
Cofactor | Mn(2+) Note: Binds 2 manganese ions per subunit. |
else case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D>
Cofactor | Mn(2+) |
end case
Similarity | Belongs to the arginase family. |
Cross-references
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case <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
PROSITE | PS01053; ARGINASE_1; 1; |
end case
Gene Ontology
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case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D>
GO:0016787; Molecular function: hydrolase activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0046872; Molecular function: metal ion binding.
GO:0030145; Molecular function: manganese ion binding.
GO:0046872; Molecular function: metal ion binding.
Keywords
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end case
Features
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From: PS51409 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 96 | 96 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1 | [HN] | ||||||||
BINDING | 120 | 120 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1 | D | ||||||||
BINDING | 120 | 120 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2 | D | ||||||||
BINDING | 122 | 122 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2 | H | ||||||||
BINDING | 124 | 124 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1 | D | ||||||||
BINDING | 213 | 213 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1 | [DC] | ||||||||
BINDING | 213 | 213 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2 | [DC] | ||||||||
BINDING | 215 | 215 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2 | D |
Additional information
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Size range | 260-350 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Examples | Q9HQD7 (HUTG_HALSA); P46637 (ARGI1_ARATH): [Recover all] |
Scope | Eukaryota
Bacteria
Archaea |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Archaea [6] Bacteria [180] Eukaryota [42] All [ 228 ]
- Retrieve set of proteins with 3D structure for this domain