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ProRule PRU00742


General rule information [?]

Accession PRU00742
Dates 25-NOV-2008 (Created)
19-NOV-2022 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51409; ARGINASE_2
Name Arginase family
Function Arginase family proteins are ureohydrolases with important roles in arginine/agmatine metabolism, the urea cycle, histidine degradation, and other pathways. The family includes arginase and related enzymes of ~300 amino acids that typically contain two manganese ions in the active site.
Scope(s) Eukaryota
Bacteria
Archaea
Example(s) Q9HQD7 (HUTG_HALSA); P46637 (ARGI1_ARATH);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
Protein name + RecName: EC=3.5.3.-;
end case

Comments [?]

case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
else case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D>
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
end case
SIMILARITYBelongs to the arginase family.

Keywords [?]


Gene Ontology [?]

case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D>
GO:0016787; Molecular function:hydrolase activity
GO:0030145; Molecular function:manganese ion binding
GO:0046872; Molecular function:metal ion binding

Cross-references [?]

PROSITE PS01053; ARGINASE_1; 1;

Features [?]

From: PS51409
Key From To Description Tag Condition FTGroup
BINDING 96 96 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#1"
[HN]
BINDING 120 120 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#1"
D
BINDING 120 120 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#2"
D
BINDING 122 122 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#2"
H
BINDING 124 124 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#1"
D
BINDING 213 213 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#1"
[DC]
BINDING 213 213 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#2"
[DC]
BINDING 215 215 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#2"
D

Additional information [?]

Size range 260-350 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]