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annotation rule: PRU00742

General rule information [?]

Accession PRU00742
Dates 25-NOV-2008 (Created)
10-OCT-2014 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS51409; ARGINASE_2
Names Arginase family; ureohydrolase superfamily
Function Arginase family proteins are ureohydrolases with important roles in arginine/agmatine metabolism, the urea cycle, histidine degradation, and other pathways. The family includes arginase and related enzymes of ~300 amino acids that typically contain two manganese ions in the active site.

Propagated annotation [?]


Description [?]

case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
+ RecName: EC=3.5.3.-;
end case


Comments [?]

case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
Cofactor Mn(2+)
Note: Binds 2 manganese ions per subunit.
else case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D>
Cofactor Mn(2+)
end case

Similarity Belongs to the arginase family.

Cross-references [?]

case <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
PROSITE PS01053; ARGINASE_1; 1;
end case


Gene Ontology [?]

case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D>
GO:0016787; Molecular function: hydrolase activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

end case


Features [?]

From: PS51409
Key     From     To       Description   Tag   Condition   FTGroup
METAL     96     96       Manganese #1     [HN]  
METAL     120     120       Manganese #1     D  
METAL     120     120       Manganese #2     D  
METAL     122     122       Manganese #2     H  
METAL     124     124       Manganese #1     D  
METAL     213     213       Manganese #1     [DC]  
METAL     213     213       Manganese #2     [DC]  
METAL     215     215       Manganese #2     D  

Additional information [?]

Size range 260-350 amino acids
Related rules None
Repeats 1
Topology Undefined
Examples Q9HQD7 (HUTG_HALSA); P46637 (ARGI1_ARATH): [Recover all]
Scope
Eukaryota
Bacteria
Archaea

Copyright

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.



UniProtKB rule member sequences [?]