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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00742


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00742
General rule information [?]

Accession PRU00742
Dates 25-NOV-2008 (Created)
19-NOV-2022 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51409; ARGINASE_2
Name Arginase family
Function Arginase family proteins are ureohydrolases with important roles in arginine/agmatine metabolism, the urea cycle, histidine degradation, and other pathways. The family includes arginase and related enzymes of ~300 amino acids that typically contain two manganese ions in the active site.
Scope(s) Eukaryota
Bacteria
Archaea
Example(s) Q9HQD7; P46637;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
Protein name + RecName: EC=3.5.3.-;
end case

Comments [?]

case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
else case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D>
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
end case
SIMILARITYBelongs to the arginase family.

Keywords [?]

Hydrolase
Manganese
Metal-binding
end case

Gene Ontology [?]

case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D>
GO:0016787; Molecular function:hydrolase activity
GO:0030145; Molecular function:manganese ion binding
GO:0046872; Molecular function:metal ion binding

Cross-references [?]

PROSITE PS01053; ARGINASE_1; 1;

Features [?]

From: PS51409
Key From To Description Tag Condition FTGroup
BINDING 96 96 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#1"		 [HN]
BINDING 120 120 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#1"		 D
BINDING 120 120 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#2"		 D
BINDING 122 122 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#2"		 H
BINDING 124 124 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#1"		 D
BINDING 213 213 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#1"		 [DC]
BINDING 213 213 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#2"		 [DC]
BINDING 215 215 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#2"		 D

Additional information [?]

Size range 260-350 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]