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General rule information [?]

Accession PRU00742
Dates 25-NOV-2008 (Created)
19-NOV-2022 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS51409; ARGINASE_2
Names Arginase family; ureohydrolase superfamily
Function Arginase family proteins are ureohydrolases with important roles in arginine/agmatine metabolism, the urea cycle, histidine degradation, and other pathways. The family includes arginase and related enzymes of ~300 amino acids that typically contain two manganese ions in the active site.

Propagated annotation [?]

Description [?]

case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
+ RecName: EC 3.5.3.-;
end case

Comments [?]

case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
Cofactor Mn(2+)
Note: Binds 2 manganese ions per subunit.
else case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D>
Cofactor Mn(2+)
end case

Similarity Belongs to the arginase family.

Cross-references [?]

case <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
end case

Gene Ontology [?]

case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D>
GO:0016787; Molecular function: hydrolase activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

end case

Features [?]

From: PS51409
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     96     96       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1     [HN]  
BINDING     120     120       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1     D  
BINDING     120     120       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2     D  
BINDING     122     122       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2     H  
BINDING     124     124       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1     D  
BINDING     213     213       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1     [DC]  
BINDING     213     213       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2     [DC]  
BINDING     215     215       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2     D  

Additional information [?]

Size range 260-350 amino acids
Related rules None
Repeats 1
Topology Undefined
Examples Q9HQD7 (HUTG_HALSA); P46637 (ARGI1_ARATH): [Recover all]


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UniProtKB rule member sequences [?]