PRU00742

General rule information [?]

Accession	PRU00742
Dates	25-NOV-2008 (Created) 19-NOV-2022 (Last updated, Version 8)

Data class

Domain

Predictors

PROSITE; PS51409; ARGINASE_2

Names

Arginase family; ureohydrolase superfamily

Function

Arginase family proteins are ureohydrolases with important roles in arginine/agmatine metabolism, the urea cycle, histidine degradation, and other pathways. The family includes arginase and related enzymes of ~300 amino acids that typically contain two manganese ions in the active site.

Propagated annotation [?]

Description [?]

case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>

+ RecName: EC 3.5.3.-;

end case

Comments [?]

case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>

Cofactor

Mn(2+)
Note: Binds 2 manganese ions per subunit.

else case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D>

Cofactor

Mn(2+)

end case

Similarity

Belongs to the arginase family.

Cross-references [?]

case <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>

PROSITE

PS01053; ARGINASE_1; 1;

end case

Gene Ontology [?]

case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D>

GO:0016787; Molecular function: hydrolase activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

Hydrolase
Manganese
Metal-binding

end case

Features [?]

From: PS51409

Key From To Description Tag Condition FTGroup

BINDING 96 96 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1 [HN]

BINDING 120 120 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1 D

BINDING 120 120 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2 D

BINDING 122 122 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2 H

BINDING 124 124 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1 D

BINDING 213 213 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1 [DC]

BINDING 213 213 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2 [DC]

BINDING 215 215 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2 D

Additional information [?]

Size range	260-350 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Examples	Q9HQD7 (HUTG_HALSA); P46637 (ARGI1_ARATH): [Recover all]
Scope	Eukaryota Bacteria Archaea

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Archaea [6]

Bacteria [180]

Eukaryota [42]

All [ 228 ]
Retrieve set of proteins with 3D structure for this domain

Archaea	[6]
Bacteria	[180]
Eukaryota	[42]
All	[ 228 ]