General rule information
[?]
Accession |
PRU00764 |
Dates |
2-MAR-2009 (Created) 14-MAY-2022 (Last updated, Version 10) |
Predictors |
PROSITE; PS51435; AP_NUCLEASE_F1_4
|
Name |
AP endonucleases family 1 |
Function |
Exonuclease III and AP endonuclease 1 related enzymes play a role in DNA repair. These nucleases cleave phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. |
Propagated annotation
[?]
case <OC:Eukaryota>
AltName: Full=DNA-(apurinic or apyrimidinic site) endonuclease;
EC 3.1.-.-; |
else case <OC:Bacteria>
AltName: Full=Exodeoxyribonuclease III;
Short=Exonuclease III;
Short=EXO III;
EC 3.1.11.2; |
end case
case <OC:Eukaryota>
Subcellular location |
Nucleus. |
else case <OC:Bacteria>
Catalytic activity |
Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.2; |
Subcellular location |
Cytoplasm. |
end case
Similarity |
Belongs to the DNA repair enzymes AP/exoA family. |
case <Feature:PS51435:40=E>
PROSITE |
PS00726; AP_NUCLEASE_F1_1; 1; |
end case
case <OC:Eukaryota>
GO:0003906; Molecular function: DNA-(apurinic or apyrimidinic site) endonuclease activity.
GO:0005634; Cellular component: nucleus.
else case <OC:Bacteria>
GO:0000287; Molecular function: magnesium ion binding.
GO:0008853; Molecular function: exodeoxyribonuclease III activity.
GO:0005737; Cellular component: cytoplasm.
end case
case <OC:Eukaryota>
else case <OC:Bacteria>
end case
From: PS51435 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
ACT_SITE
|
|
258
|
|
258
|
|
Proton acceptor
|
|
|
|
H
|
|
|
BINDING
|
|
7
|
|
7
|
|
/ligand="Mg(2+)" /ligand_id="18420
|
|
|
|
N
|
|
|
BINDING
|
|
40
|
|
40
|
|
/ligand="Mg(2+)" /ligand_id="18420
|
|
|
|
E
|
|
|
BINDING
|
|
158
|
|
158
|
|
/ligand="Mg(2+)" /ligand_id="18420
|
|
|
|
D
|
|
|
BINDING
|
|
160
|
|
160
|
|
/ligand="Mg(2+)" /ligand_id="18420
|
|
|
|
N
|
|
|
BINDING
|
|
257
|
|
257
|
|
/ligand="Mg(2+)" /ligand_id="18420
|
|
|
|
D
|
|
|
BINDING
|
|
258
|
|
258
|
|
/ligand="Mg(2+)" /ligand_id="18420
|
|
|
|
H
|
|
|
Additional information
[?]
Size range |
230-370 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Examples |
P28352 (APEX1_MOUSE); P44318 (EX3_HAEIN): [Recover all] |
Scope |
Eukaryota
Bacteria |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]