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|
| annotation rule: PRU00764 |
General rule information
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| Accession | PRU00764 |
| Dates | 2-MAR-2009 (Created) 27-OCT-2018 (Last updated, Version 6) |
| Data class | Domain |
| Predictors | PROSITE; PS51435; AP_NUCLEASE_F1_4 |
| Name | AP endonucleases family 1 |
| Function | Exonuclease III and AP endonuclease 1 related enzymes play a role in DNA repair. These nucleases cleave phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. |
Propagated annotation
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Description
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case <OC:Eukaryota>
| AltName: Full=DNA-(apurinic or apyrimidinic site) lyase; EC=4.2.99.18; |
else case <OC:Bacteria>
| AltName: Full=Exodeoxyribonuclease III; Short=Exonuclease III; Short=EXO III; EC=3.1.11.2; |
end case
Comments
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case <OC:Eukaryota>
| Catalytic activity | Reaction=The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'- terminal unsaturated sugar and a product with a terminal 5'- phosphate.; EC=4.2.99.18;. |
| Subcellular location | Nucleus. |
else case <OC:Bacteria>
| Catalytic activity | Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.2;. |
| Subcellular location | Cytoplasm. |
end case
| Similarity | Belongs to the DNA repair enzymes AP/exoA family. |
Cross-references
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case <Feature:PS51435:40=E>
| PROSITE | PS00726; AP_NUCLEASE_F1_1; 1; |
end case
Gene Ontology
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GO:0003677; Molecular function: DNA binding.
GO:0004519; Molecular function: endonuclease activity.
GO:0006281; Biological process: DNA repair.
GO:0004519; Molecular function: endonuclease activity.
GO:0006281; Biological process: DNA repair.
case <OC:Eukaryota>
GO:0003906; Molecular function: DNA-(apurinic or apyrimidinic site) endonuclease activity.
GO:0005634; Cellular component: nucleus.
GO:0005634; Cellular component: nucleus.
else case <OC:Bacteria>
GO:0000287; Molecular function: magnesium ion binding.
GO:0008853; Molecular function: exodeoxyribonuclease III activity.
GO:0005737; Cellular component: cytoplasm.
GO:0008853; Molecular function: exodeoxyribonuclease III activity.
GO:0005737; Cellular component: cytoplasm.
end case
Keywords
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case <OC:Eukaryota>
else case <OC:Bacteria>
end case
Features
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| From: PS51435 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 258 | 258 | Proton acceptor | H | ||||||||
| METAL | 7 | 7 | Magnesium or manganese | N | ||||||||
| METAL | 40 | 40 | Magnesium or manganese | E | ||||||||
| METAL | 158 | 158 | Magnesium or manganese | D | ||||||||
| METAL | 160 | 160 | Magnesium or manganese | N | ||||||||
| METAL | 257 | 257 | Magnesium or manganese | D | ||||||||
| METAL | 258 | 258 | Magnesium or manganese | H | ||||||||
Additional information
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| Size range | 230-370 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Examples | P28352 (APEX1_MOUSE); P44318 (EX3_HAEIN): [Recover all] |
| Scope | Eukaryota
Bacteria |
| Comments | None |
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UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Bacteria [7] Eukaryota [19] All [ 26 ]
- Retrieve set of proteins with 3D structure for this domain