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annotation rule: PRU00820

General rule information [?]

Accession PRU00820
Dates 16-JUL-2010 (Created)
21-NOV-2019 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS51487; NBD
Name NBD domain
Function The Rag-1 nonamer binding domain (NBD) is a DNA-binding domain involved in the somatic site-specific recombination reaction known as V(D)J recombination.

Propagated annotation [?]


Comments [?]

Subcellular location Nucleus.
Domain The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.
Similarity Belongs to the RAG1 family.

Gene Ontology [?]

GO:0005634; Cellular component: nucleus.
GO:0043565; Molecular function: sequence-specific DNA binding.
GO:0033151; Biological process: V(D)J recombination.

Keywords [?]

DNA recombination
DNA-binding
Nucleus

Features [?]

From: PS51487
Key     From     To       Description   Tag   Condition   FTGroup
DNA_BIND     1     68       NBD        

Additional information [?]

Size range 58-78 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q91829 (RAG1_XENLA)
Scope
Eukaryota; Euteleostomi
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]