We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00820
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00820
General rule information
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| Accession | PRU00820 |
| Dates | 16-JUL-2010 (Created)
21-NOV-2019 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51487; NBD |
Name | NBD domain |
| Function | The Rag-1 nonamer binding domain (NBD) is a DNA-binding domain involved in the somatic site-specific recombination reaction known as V(D)J recombination. |
| Scope(s) |
Eukaryota Euteleostomi |
| Example(s) | Q91829; |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Nucleus. |
| DOMAIN | The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp. |
| SIMILARITY | Belongs to the RAG1 family. |
Keywords
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Gene Ontology
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| GO:0005634; Cellular component:nucleus |
| GO:0043565; Molecular function:sequence-specific DNA binding |
| GO:0033151; Biological process:V(D)J recombination |
Features
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| From: PS51487 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DNA_BIND | 1 | 68 | /note="NBD" | |||||||||
Additional information
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| Size range | 58-78 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [8] All [ 8 ]
- Retrieve set of proteins with 3D structure for this domain