ProRule PRU00820

General rule information [?]

Accession PRU00820
Dates 16-JUL-2010 (Created)
21-NOV-2019 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51487; NBD
Name NBD domain
Function The Rag-1 nonamer binding domain (NBD) is a DNA-binding domain involved in the somatic site-specific recombination reaction known as V(D)J recombination.
Scope(s) Eukaryota
Example(s) Q91829 (RAG1_XENLA);

Propagated annotation [?]

Comments [?]

DOMAINThe NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.
SIMILARITYBelongs to the RAG1 family.

Keywords [?]

Gene Ontology [?]

GO:0005634; Cellular component:nucleus
GO:0043565; Molecular function:sequence-specific DNA binding
GO:0033151; Biological process:V(D)J recombination

Features [?]

From: PS51487
Key From To Description Tag Condition FTGroup
DNA_BIND 1 68 /note="NBD"

Additional information [?]

Size range 58-78 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]