ProRule PRU00820
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00820 |
| Accession | PRU00820 |
| Dates | 16-JUL-2010 (Created)
21-NOV-2019 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51487; NBD |
Name | NBD domain |
| Function | The Rag-1 nonamer binding domain (NBD) is a DNA-binding domain involved in the somatic site-specific recombination reaction known as V(D)J recombination. |
| Scope(s) |
Eukaryota Euteleostomi |
| Example(s) | Q91829 (RAG1_XENLA); |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Nucleus. |
| DOMAIN | The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp. |
| SIMILARITY | Belongs to the RAG1 family. |
Keywords
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Gene Ontology
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| GO:0005634; Cellular component:nucleus |
| GO:0043565; Molecular function:sequence-specific DNA binding |
| GO:0033151; Biological process:V(D)J recombination |
Features
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| From: PS51487 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DNA_BIND | 1 | 68 | /note="NBD" | |||||||||
Additional information
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| Size range | 58-78 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [8] All [ 8 ]
- Retrieve set of proteins with 3D structure for this domain