PRU00820

Accession	PRU00820
Dates	16-JUL-2010 (Created) 21-NOV-2019 (Last updated, Version 4)

Data class

Domain

Predictors

PROSITE; PS51487; NBD

Name	NBD domain

Function

The Rag-1 nonamer binding domain (NBD) is a DNA-binding domain involved in the somatic site-specific recombination reaction known as V(D)J recombination.

Subcellular location	Nucleus.
Domain	The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.
Similarity	Belongs to the RAG1 family.

GO:0005634; Cellular component: nucleus.
GO:0043565; Molecular function: sequence-specific DNA binding.
GO:0033151; Biological process: V(D)J recombination.

DNA recombination
DNA-binding
Nucleus

From: PS51487

Key

From

To

Description

Tag

Condition

FTGroup

DNA_BIND

1

68

NBD

Size range	58-78 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q91829 (RAG1_XENLA)
Scope	Eukaryota; Euteleostomi
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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• UniProtKB/Swiss-Prot sets
  

  Eukaryota

  [8]

  
  
• Retrieve set of proteins with 3D structure for this domain