General rule information
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Accession |
PRU00820 |
Dates |
16-JUL-2010 (Created) 21-NOV-2019 (Last updated, Version 4) |
Function |
The Rag-1 nonamer binding domain (NBD) is a DNA-binding domain involved in the somatic site-specific recombination reaction known as V(D)J recombination. |
Propagated annotation
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Subcellular location |
Nucleus. |
Domain |
The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp. |
Similarity |
Belongs to the RAG1 family. |
GO:0005634; Cellular component: nucleus.
GO:0043565; Molecular function: sequence-specific DNA binding.
GO:0033151; Biological process: V(D)J recombination.
From: PS51487 |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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DNA_BIND
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1
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68
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NBD
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Additional information
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Size range |
58-78 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q91829 (RAG1_XENLA) |
Scope |
Eukaryota; Euteleostomi |
Comments |
None |
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UniProtKB rule member sequences
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