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ProRule PRU00840
General rule information
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| Accession | PRU00840 |
| Dates | 8-NOV-2010 (Created)
27-JUN-2022 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51507; IRF_2 |
Name | IRF tryptophan pentad repeat DNA-binding domain |
| Function | The IRF tryptophan pentad repeat DNA-binding domain has an alpha/ beta architecture comprising a cluster of three alpha-helices (alpha1-alpha3) flanked on one side by a mixed four-stranded beta-sheet (beta1-beta4). It forms a helix-turn-helix motif that binds to ISRE consensus sequences found in target promoters. |
| Scope(s) |
Eukaryota Euteleostomi |
| Example(s) | O14896 (IRF6_HUMAN); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the IRF family. |
Keywords
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Gene Ontology
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| GO:0006355; Biological process:regulation of DNA-templated transcription |
| GO:0006351; Biological process:DNA-templated transcription |
| GO:0005634; Cellular component:nucleus |
| GO:0003677; Molecular function:DNA binding |
Cross-references
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| PROSITE | PS00601; IRF_1; 1; |
Features
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| From: PS51507 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DNA_BIND | 1 | 107 | /note="IRF tryptophan pentad repeat" | |||||||||
Additional information
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| Size range | 95-128 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [30] Viruses [4] All [ 34 ]
- Retrieve set of proteins with 3D structure for this domain