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General rule information [?]

Accession PRU00840
Dates 8-NOV-2010 (Created)
27-JUN-2022 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51507; IRF_2
Name IRF tryptophan pentad repeat DNA-binding domain
Function The IRF tryptophan pentad repeat DNA-binding domain has an alpha/ beta architecture comprising a cluster of three alpha-helices (alpha1-alpha3) flanked on one side by a mixed four-stranded beta-sheet (beta1-beta4). It forms a helix-turn-helix motif that binds to ISRE consensus sequences found in target promoters.

Propagated annotation [?]

Comments [?]

Similarity Belongs to the IRF family.

Cross-references [?]

PROSITE PS00601; IRF_1; 1;

Gene Ontology [?]

GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0006351; Biological process: DNA-templated transcription.
GO:0005634; Cellular component: nucleus.
GO:0003677; Molecular function: DNA binding.

Keywords [?]

Features [?]

From: PS51507
Key     From     To       Description   Tag   Condition   FTGroup
DNA_BIND     1     107       IRF tryptophan pentad repeat        

Additional information [?]

Size range 95-128 amino acids
Related rules None
Repeats 1
Topology Undefined
Example O14896 (IRF6_HUMAN)
Eukaryota; Euteleostomi
Comments None


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UniProtKB rule member sequences [?]