PRU00840

General rule information [?]

Accession	PRU00840
Dates	8-NOV-2010 (Created) 27-JUN-2022 (Last updated, Version 6)

Data class

Domain

Predictors

PROSITE; PS51507; IRF_2

Name	IRF tryptophan pentad repeat DNA-binding domain

Function

The IRF tryptophan pentad repeat DNA-binding domain has an alpha/ beta architecture comprising a cluster of three alpha-helices (alpha1-alpha3) flanked on one side by a mixed four-stranded beta-sheet (beta1-beta4). It forms a helix-turn-helix motif that binds to ISRE consensus sequences found in target promoters.

Propagated annotation [?]

Comments [?]

Similarity

Belongs to the IRF family.

Cross-references [?]

PROSITE

PS00601; IRF_1; 1;

Gene Ontology [?]

GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0006351; Biological process: DNA-templated transcription.
GO:0005634; Cellular component: nucleus.
GO:0003677; Molecular function: DNA binding.

Keywords [?]

DNA-binding
Nucleus
Transcription
Transcription regulation

Features [?]

From: PS51507

Key From To Description Tag Condition FTGroup

DNA_BIND 1 107 IRF tryptophan pentad repeat

Additional information [?]

Size range	95-128 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	O14896 (IRF6_HUMAN)
Scope	Eukaryota; Euteleostomi
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Eukaryota [30]

Viruses [4]

All [ 34 ]
Retrieve set of proteins with 3D structure for this domain

Eukaryota	[30]
Viruses	[4]
All	[ 34 ]