ProRule PRU00840

General rule information [?]

Accession PRU00840
Dates 8-NOV-2010 (Created)
27-JUN-2022 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51507; IRF_2
Name IRF tryptophan pentad repeat DNA-binding domain
Function The IRF tryptophan pentad repeat DNA-binding domain has an alpha/ beta architecture comprising a cluster of three alpha-helices (alpha1-alpha3) flanked on one side by a mixed four-stranded beta-sheet (beta1-beta4). It forms a helix-turn-helix motif that binds to ISRE consensus sequences found in target promoters.
Scope(s) Eukaryota
Example(s) O14896 (IRF6_HUMAN);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the IRF family.

Keywords [?]

Gene Ontology [?]

GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription
GO:0005634; Cellular component:nucleus
GO:0003677; Molecular function:DNA binding

Cross-references [?]

PROSITE PS00601; IRF_1; 1;

Features [?]

From: PS51507
Key From To Description Tag Condition FTGroup
DNA_BIND 1 107 /note="IRF tryptophan pentad repeat"

Additional information [?]

Size range 95-128 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]