We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

ProRule PRU00895

View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00895

General rule information [?]

Accession	PRU00895
Dates	25-NOV-2011 (Created) 11-JAN-2024 (Last updated, Version 29)
Data class	Domain;
Predictors	PROSITE; PS51562; RNA_CAP0_MT
Name	mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56)
Function	mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to G(5')pppR-RNA to form m(7)G(5')pppR-RNA and S-adenosyl-L-homocysteine.
Scope(s)	Eukaryota Viruses
Example(s)	Q8SR66; P04298;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name

+ RecName: EC=2.1.1.56;

Comments [?]

CATALYTIC ACTIVITY	Reaction=a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S- adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:67008, Rhea:RHEA-COMP:17166, Rhea:RHEA- COMP:17167, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461, ChEBI:CHEBI:167617; EC=2.1.1.56;
case <OC:Eukaryota>
SIMILARITY	Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
else case <OC:Viruses>
SIMILARITY	In the C-terminal section; belongs to the class I-like SAM- binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
end case

Keywords [?]

S-adenosyl-L-methionine

Transferase

Gene Ontology [?]

GO:0003723; Molecular function:RNA binding

GO:0004482; Molecular function:mRNA 5'-cap (guanine-N7-)-methyltransferase activity

GO:0006370; Biological process:7-methylguanosine mRNA capping

GO:0032259; Biological process:methylation

GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]

From: PS51562

Key

From

Description

Tag

Condition

FTGroup

DOMAIN

from

/note="mRNA cap 0 methyltransferase #"

BINDING

/ligand="mRNA"
/ligand_id="ChEBI:CHEBI:33699"
/ligand_part="mRNA cap"

x-N

case <OC:Eukaryota>

BINDING