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annotation rule: PRU00895

General rule information [?]

Accession PRU00895
Dates 15-MAR-2012 (Created)
12-MAR-2021 (Last updated, Version 22)
Data class Domain
Predictors PROSITE; PS51562; RNA_CAP0_MT
Name mRNA (guanine-N(7))-methyltransferase (EC
Function mRNA (guanine-N(7))-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to G(5')pppR-RNA to form m(7)G(5')pppR-RNA and S-adenosyl-L-homocysteine.

Propagated annotation [?]

Description [?]

+ RecName: EC;

Comments [?]

Catalytic activity RHEA:67008: a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine
case <OC:Eukaryota>
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
else case <OC:Viruses>
Similarity In the C-terminal section; belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
end case

Gene Ontology [?]

GO:0003723; Molecular function: RNA binding.
GO:0004482; Molecular function: mRNA (guanine-N7-)-methyltransferase activity.
GO:0006370; Biological process: 7-methylguanosine mRNA capping.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]

Features [?]

From: PS51562
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       mRNA cap 0 methyltransferase #        
case <OC:Viruses>
REGION     34     35       S-adenosyl-L-methionine binding     L-N  
end case

REGION     50     51       mRNA cap binding     x-N  
case <OC:Eukaryota>
REGION     132     133       S-adenosyl-L-methionine binding     [DE]-x  
end case

REGION     156     158       S-adenosyl-L-methionine binding     x-F-x  
BINDING     54     54       S-adenosyl-L-methionine     K  
BINDING     76     76       S-adenosyl-L-methionine; via carbonyl oxygen     [ADCG]  
BINDING     98     98       S-adenosyl-L-methionine     D  
SITE     79     79       mRNA cap binding     K  
SITE     85     85       mRNA cap binding     K  
SITE     110     110       mRNA cap binding     R  
SITE     160     160       mRNA cap binding     H  
SITE     249     249       mRNA cap binding     E  
SITE     315     315       mRNA cap binding     Y  

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Examples Q8SR66 (MCES_ENCCU); P04298 (MCEL_VACCW): [Recover all]
Comments None


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UniProtKB rule member sequences [?]