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annotation rule: PRU00956

General rule information [?]

Accession PRU00956
Dates 14-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain
case <Length>=1280> and <Length<=1920>
Predictors PROSITE; PS51624; SAM_MT_TRMH_2
end case

Name RNA methyltransferase TRMH
Function tRNA guanosine-2'-O-methyltransferase (EC 2.1.1.34) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to tRNA to form tRNA containing 2'-O-methylguanosine and S-adenosyl-L-homocysteine. 16S rRNA (guanine(527)-N(7))-methyltransferase (EC 2.1.1.170) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to guanosine(527) in 16S rRNA to form N(7)-methylguanosine(527) in 16S rRNA and S-adenosyl-L-homocysteine. tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase (EC 2.1.1.200) is an enzyme that transfers a methyl group from S-adenosyl-L methionine (SAM) to (1)cytidine(32) in tRNA to form 2'-O-methylcytidine(32) in tRNA and S- adenosyl-L-homocysteine. tRNA (cytidine(34)-2'-O)-methyltransferase (EC 2.1.1.207) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to (1)cytidine(34) in tRNA to form 2'-O-methylcytidine(34) in tRNA and S adenosyl-L-homocysteine.

Propagated annotation [?]


Description [?]

+ RecName: EC 2.1.1.-;

Comments [?]

Similarity Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

Gene Ontology [?]

GO:0003723; Molecular function: RNA binding.
GO:0008173; Molecular function: RNA methyltransferase activity.
GO:0008757; Molecular function: S-adenosylmethionine-dependent methyltransferase activity.
GO:0006396; Biological process: RNA processing.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]


Features [?]

From: PS51624
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     1545     1545       S-adenosyl-L-methionine; via carbonyl oxygen     G  
BINDING     1565     1565       S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen     I  
BINDING     1574     1574       S-adenosyl-L-methionine; via amide nitrogen     L  

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q13395 (TARB1_HUMAN)
Scope
Eukaryota; Homo
Comments None

Copyright

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