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ProRule PRU00956


General rule information [?]

Accession PRU00956
Dates 14-DEC-2011 (Created)
19-NOV-2022 (Last updated, Version 8)
Data class Domain;
Predictors
case c? <Length>=1280> and <Length<=1920>
PROSITE; PS51624; SAM_MT_TRMH_2
end case
Name RNA methyltransferase TRMH
Function tRNA guanosine-2'-O-methyltransferase (EC 2.1.1.34) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to tRNA to form tRNA containing 2'-O-methylguanosine and S-adenosyl-L-homocysteine. 16S rRNA (guanine(527)-N(7))-methyltransferase (EC 2.1.1.170) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to guanosine(527) in 16S rRNA to form N(7)-methylguanosine(527) in 16S rRNA and S-adenosyl-L-homocysteine. tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase (EC 2.1.1.200) is an enzyme that transfers a methyl group from S-adenosyl-L methionine (SAM) to (1)cytidine(32) in tRNA to form 2'-O-methylcytidine(32) in tRNA and S- adenosyl-L-homocysteine. tRNA (cytidine(34)-2'-O)-methyltransferase (EC 2.1.1.207) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to (1)cytidine(34) in tRNA to form 2'-O-methylcytidine(34) in tRNA and S adenosyl-L-homocysteine.
Scope(s) Eukaryota
Homo
Example(s) Q13395 (TARB1_HUMAN);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.-;

Comments [?]

SIMILARITYBelongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

Keywords [?]

Methyltransferase
RNA-binding
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0003723; Molecular function:RNA binding
GO:0008173; Molecular function:RNA methyltransferase activity
GO:0008757; Molecular function:S-adenosylmethionine-dependent methyltransferase activity
GO:0006396; Biological process:RNA processing
GO:0032259; Biological process:methylation
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]

From: PS51624
Key From To Description Tag Condition FTGroup
BINDING 1545 1545 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 G
BINDING 1565 1565 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 I
BINDING 1574 1574 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 L

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]