We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00956
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00956
General rule information
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| Accession | PRU00956 |
| Dates | 14-DEC-2011 (Created)
19-NOV-2022 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
case c? <Length>=1280> and <Length<=1920>
PROSITE; PS51624; SAM_MT_TRMH_2 end case
|
Name | RNA methyltransferase TRMH |
| Function | tRNA guanosine-2'-O-methyltransferase (EC 2.1.1.34) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to tRNA to form tRNA containing 2'-O-methylguanosine and S-adenosyl-L-homocysteine. 16S rRNA (guanine(527)-N(7))-methyltransferase (EC 2.1.1.170) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to guanosine(527) in 16S rRNA to form N(7)-methylguanosine(527) in 16S rRNA and S-adenosyl-L-homocysteine. tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase (EC 2.1.1.200) is an enzyme that transfers a methyl group from S-adenosyl-L methionine (SAM) to (1)cytidine(32) in tRNA to form 2'-O-methylcytidine(32) in tRNA and S- adenosyl-L-homocysteine. tRNA (cytidine(34)-2'-O)-methyltransferase (EC 2.1.1.207) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to (1)cytidine(34) in tRNA to form 2'-O-methylcytidine(34) in tRNA and S adenosyl-L-homocysteine. |
| Scope(s) |
Eukaryota Homo |
| Example(s) | Q13395; |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.-; |
Comments
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| SIMILARITY | Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. |
Keywords
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Gene Ontology
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| GO:0003723; Molecular function:RNA binding |
| GO:0008173; Molecular function:RNA methyltransferase activity |
| GO:0008757; Molecular function:S-adenosylmethionine-dependent methyltransferase activity |
| GO:0006396; Biological process:RNA processing |
| GO:0032259; Biological process:methylation |
| GO:0046500; Biological process:S-adenosylmethionine metabolic process |
Features
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| From: PS51624 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 1545 | 1545 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G | ||||||||
| BINDING | 1565 | 1565 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
I | ||||||||
| BINDING | 1574 | 1574 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
L | ||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [2] All [ 2 ]
- Retrieve set of proteins with 3D structure for this domain