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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01004


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01004
General rule information [?]

Accession PRU01004
Dates 04-APR-2013 (Created)
08-OCT-2024 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS51669; 4FE4S_MOW_BIS_MGD
Name Prokaryotic molybdopterin oxidoreductases 4Fe-4S domain
Function The Mo/W bis-MGD oxydoreductases contains a domain that coordinates a [4Fe-4S] cluster. The cluster is ligated either by four Cys residues or three Cys residues and one His residue.
Scope(s) Bacteria
Eukaryota
Archaea
Methanobacteriati
Example(s) A8GHJ4;

Propagated annotation [?]

Keywords [?]

Iron
Iron-sulfur
Metal-binding
4Fe-4S
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding

Cross-references [?]

PROSITE PS00551; MOLYBDOPTERIN_PROK_1; 0-1;

Features [?]

From: PS51669
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="4Fe-4S Mo/W bis-MGD-type #"
BINDING 8 8 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"		 [CH] 1
BINDING 11 11 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"		 [C] 1
BINDING 15 15 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"		 [C] 1
BINDING 43 43 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"		 [C] 1

Additional information [?]

Size range 33-98 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]