ProRule PRU01018

Accession	PRU01018
Dates	8-AUG-2024 (Created) -- (Last updated, Version 2)
Data class	Domain;
Predictors	PROSITE; PS51681; SAM_MT_NNMT_PNMT_TEMT
Name	NNMT, PNMT, TEMT and homologues.
Function	Function: Nicotinamide N-methyltransferase (EC 2.1.1.1) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to form 1-methylnicotinamide and S-adenosyl-L-homocysteine. Phenylethanolamine N-methyltransferase (EC 2.1.1.28) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phenylethanolamine to form N-methylphenylethanolamine and S-adenosyl-L homocysteine. Amine N-methyltransferase (EC 2.1.1.49) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to an amine to form a methylated amine and S-adenosyl-L-homocysteine. Thioether S-methyltransferase (EC 2.1.1.96) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to dimethyl sulfide to form trimethylsulfonium and S-adenosyl-L-homocysteine.
Scope(s)	Eukaryota Metazoa
Example(s)	P40261 (NNMT_HUMAN);

From: PS51681
Key	From	To	Description	Tag	Condition	FTGroup
BINDING	13	13	/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789"		Y
BINDING	18	18	/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789"		Y
BINDING	55	56	/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789"		G-[SA]
BINDING	61	61	/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789"		Y
BINDING	77	77	/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789"		D
BINDING	82	82	/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789"		N
BINDING	134	135	/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789"		[DN]-[VA]
BINDING	155	155	/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789"		[TFLAV]