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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01035


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01035
General rule information [?]

Accession PRU01035
Dates 22-AUG-2014 (Created)
22-NOV-2019 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS50235; USP_3
Name Ubiquitin specific protease (USP) domain
Function The USP domain forms the peptidase family C19.
Scope(s) Eukaryota
Viruses
Mimivirus
Example(s) P39967;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the peptidase C19 family.

Keywords [?]

Hydrolase
Protease
Thiol protease
end case
Ubl conjugation pathway

Gene Ontology [?]

case <FTGroup:1>
GO:0006511; Biological process:ubiquitin-dependent protein catabolic process

Cross-references [?]

PROSITE PS00972; USP_1; 1;
PROSITE PS00973; USP_2; 1;

Features [?]

From: PS50235
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="USP #"
ACT_SITE 10 10 /note="Nucleophile" C 1
ACT_SITE 288 288 /note="Proton acceptor" H 1

Additional information [?]

Size range 94-892 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]