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ProRule PRU01080


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01080
Accession PRU01080
Dates 13-JAN-2015 (Created)
22-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51744; HC_PRO_CPD
Name Helper-component proteinase (HC-Pro) cysteine protease (CPD) domain
Function The HC-Pro CPD domain has a protease activity that autocatalytically cleaves a Gly-Gly dipeptide at its own C terminus to release HC-Pro from the rest of the viral polyprotein.
Scope(s) Viruses
Potyviridae
Example(s) P0CJ95 (MVP_BYMV);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1> and <FTGroup:2>
Protein name Contains:
RecName: Full=Helper component proteinase;
                 Short=HC-pro;
                 EC=3.4.22.45;

Comments [?]

FUNCTIONHelper component proteinase: Cysteine protease that cleaves a Gly-Gly dipeptide at its own C-terminus.
CATALYTIC ACTIVITY Reaction=Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.; EC=3.4.22.45;
end case

Keywords [?]

Hydrolase
Protease
end case

Gene Ontology [?]

case <FTGroup:1> and <FTGroup:2>
GO:0004197; Molecular function:cysteine-type endopeptidase activity

Features [?]

From: PS51744
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C6 #"
ACT_SITE 9 9 /note="For helper component proteinase activity" C 1
ACT_SITE 81 81 /note="For helper component proteinase activity" H 1
case <Feature:PS51744:119-122=[FYG]-x-[VIT]-G>
SITE 122 122+1 /note="Cleavage; by autolysis" 2
end case

Additional information [?]

Size range 110-133 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]