We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01080
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01080
General rule information
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| Accession | PRU01080 |
| Dates | 13-JAN-2015 (Created)
22-NOV-2019 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51744; HC_PRO_CPD |
Name | Helper-component proteinase (HC-Pro) cysteine protease (CPD) domain |
| Function | The HC-Pro CPD domain has a protease activity that autocatalytically cleaves a Gly-Gly dipeptide at its own C terminus to release HC-Pro from the rest of the viral polyprotein. |
| Scope(s) |
Viruses Potyviridae |
| Example(s) | P0CJ95; |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> and <FTGroup:2> | |
| Protein name | Contains: RecName: Full=Helper component proteinase; Short=HC-pro; EC=3.4.22.45; |
Comments
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| FUNCTION | Helper component proteinase: Cysteine protease that cleaves a Gly-Gly dipeptide at its own C-terminus. |
| CATALYTIC ACTIVITY | Reaction=Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.; EC=3.4.22.45; |
| end case | |
Keywords
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Gene Ontology
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| case <FTGroup:1> and <FTGroup:2> | |
| GO:0004197; Molecular function:cysteine-type endopeptidase activity | |
Features
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| From: PS51744 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase C6 #" | |||||||||
| ACT_SITE | 9 | 9 | /note="For helper component proteinase activity" | C | 1 | |||||||
| ACT_SITE | 81 | 81 | /note="For helper component proteinase activity" | H | 1 | |||||||
| case <Feature:PS51744:119-122=[FYG]-x-[VIT]-G> | ||||||||||||
| SITE | 122 | 122+1 | /note="Cleavage; by autolysis" | 2 | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 110-133 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [62] All [ 62 ]
- Retrieve set of proteins with 3D structure for this domain