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ProRule PRU01080
General rule information
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| Accession | PRU01080 |
| Dates | 13-JAN-2015 (Created)
22-NOV-2019 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51744; HC_PRO_CPD |
Name | Helper-component proteinase (HC-Pro) cysteine protease (CPD) domain |
| Function | The HC-Pro CPD domain has a protease activity that autocatalytically cleaves a Gly-Gly dipeptide at its own C terminus to release HC-Pro from the rest of the viral polyprotein. |
| Scope(s) |
Viruses Potyviridae |
| Example(s) | P0CJ95 (MVP_BYMV); |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> and <FTGroup:2> | |
| Protein name | Contains: RecName: Full=Helper component proteinase; Short=HC-pro; EC=3.4.22.45; |
Comments
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| FUNCTION | Helper component proteinase: Cysteine protease that cleaves a Gly-Gly dipeptide at its own C-terminus. |
| CATALYTIC ACTIVITY | Reaction=Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.; EC=3.4.22.45; |
| end case | |
Keywords
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Gene Ontology
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| case <FTGroup:1> and <FTGroup:2> | |
| GO:0004197; Molecular function:cysteine-type endopeptidase activity | |
Features
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| From: PS51744 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase C6 #" | |||||||||
| ACT_SITE | 9 | 9 | /note="For helper component proteinase activity" | C | 1 | |||||||
| ACT_SITE | 81 | 81 | /note="For helper component proteinase activity" | H | 1 | |||||||
| case <Feature:PS51744:119-122=[FYG]-x-[VIT]-G> | ||||||||||||
| SITE | 122 | 122+1 | /note="Cleavage; by autolysis" | 2 | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 110-133 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [62] All [ 62 ]
- Retrieve set of proteins with 3D structure for this domain