PRU01080

Accession	PRU01080
Dates	13-JAN-2015 (Created) 22-NOV-2019 (Last updated, Version 6)

Data class

Domain

Predictors

PROSITE; PS51744; HC_PRO_CPD

Names

Helper-component proteinase (HC-Pro) cysteine protease (CPD) domain; Peptidase C6 domain

Function

The HC-Pro CPD domain has a protease activity that autocatalytically cleaves a Gly-Gly dipeptide at its own C terminus to release HC-Pro from the rest of the viral polyprotein.

Contains: RecName: Full=Helper component proteinase; Short=HC-pro; EC 3.4.22.45;

Function	Helper component proteinase: Cysteine protease that cleaves a Gly-Gly dipeptide at its own C-terminus.
Catalytic activity	Reaction=Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.; EC=3.4.22.45;

GO:0004197; Molecular function: cysteine-type endopeptidase activity.

Hydrolase
Protease

From: PS51744

Key

From

To

Description

Tag

Condition

FTGroup

DOMAIN

from

to

Peptidase C6 #

ACT_SITE

9

9

For helper component proteinase activity

C

1

ACT_SITE

81

81

For helper component proteinase activity

H

1

SITE

122

122+1

Cleavage; by autolysis

2

Size range	110-133 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	P0CJ95 (MVP_BYMV)
Scope	Viruses; Potyviridae
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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• UniProtKB/Swiss-Prot sets
  

  Viruses

  [62]

  
  
• Retrieve set of proteins with 3D structure for this domain