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annotation rule: PRU01080

General rule information [?]

Accession PRU01080
Dates 13-JAN-2015 (Created)
22-NOV-2019 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51744; HC_PRO_CPD
Names Helper-component proteinase (HC-Pro) cysteine protease (CPD) domain; Peptidase C6 domain
Function The HC-Pro CPD domain has a protease activity that autocatalytically cleaves a Gly-Gly dipeptide at its own C terminus to release HC-Pro from the rest of the viral polyprotein.

Propagated annotation [?]


Description [?]

case <FTGroup:1> and <FTGroup:2>
Contains: RecName: Full=Helper component proteinase; Short=HC-pro; EC 3.4.22.45;

Comments [?]

Function Helper component proteinase: Cysteine protease that cleaves a Gly-Gly dipeptide at its own C-terminus.
Catalytic activity Reaction=Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.; EC=3.4.22.45;
end case


Gene Ontology [?]

case <FTGroup:1> and <FTGroup:2>
GO:0004197; Molecular function: cysteine-type endopeptidase activity.

Keywords [?]

Hydrolase
Protease
end case


Features [?]

From: PS51744
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase C6 #        
ACT_SITE     9     9       For helper component proteinase activity     C   1
ACT_SITE     81     81       For helper component proteinase activity     H   1
case <Feature:PS51744:119-122=[FYG]-x-[VIT]-G>
SITE     122     122+1       Cleavage; by autolysis         2
end case


Additional information [?]

Size range 110-133 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0CJ95 (MVP_BYMV)
Scope
Viruses; Potyviridae
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]