General rule information
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Accession |
PRU01080 |
Dates |
13-JAN-2015 (Created) 22-NOV-2019 (Last updated, Version 6) |
Predictors |
PROSITE; PS51744; HC_PRO_CPD
|
Names |
Helper-component proteinase (HC-Pro) cysteine protease (CPD) domain; Peptidase C6 domain |
Function |
The HC-Pro CPD domain has a protease activity that autocatalytically cleaves a Gly-Gly dipeptide at its own C terminus to release HC-Pro from the rest of the viral polyprotein. |
Propagated annotation
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case <FTGroup:1> and <FTGroup:2>
Contains:
RecName: Full=Helper component proteinase;
Short=HC-pro;
EC 3.4.22.45; |
Function |
Helper component proteinase: Cysteine protease that cleaves a Gly-Gly dipeptide at its own C-terminus. |
Catalytic activity |
Reaction=Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.; EC=3.4.22.45; |
end case
case <FTGroup:1> and <FTGroup:2>
GO:0004197; Molecular function: cysteine-type endopeptidase activity.
end case
From: PS51744 |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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DOMAIN
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from
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to
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Peptidase C6 #
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ACT_SITE
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9
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9
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For helper component proteinase activity
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C
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1
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ACT_SITE
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81
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81
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For helper component proteinase activity
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H
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1
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case <Feature:PS51744:119-122=[FYG]-x-[VIT]-G>
SITE
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122
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122+1
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Cleavage; by autolysis
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2
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end case
Additional information
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Size range |
110-133 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
P0CJ95 (MVP_BYMV) |
Scope |
Viruses; Potyviridae |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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