Home  |  Contact
annotation rule: PRU01134

General rule information [?]

Accession PRU01134
Dates 19-APR-2016 (Created)
19-NOV-2022 (Last updated, Version 7)
Data class Domain
Predictors PROSITE; PS51144; ALPHA_CA_2
Name Alpha-carbonic anhydrase domain
Function Fill in

Propagated annotation [?]


Description [?]

case <FTGroup:1> and <FTGroup:2>
+ AltName: Full=Carbonic anhydrase; EC 4.2.1.1;

Comments [?]

Catalytic activity RHEA:10748: H(+) + hydrogencarbonate = CO2 + H2O
EC 4.2.1.1
end case


Cross-references [?]

case <FTGroup:2>
PROSITE PS00162; ALPHA_CA_1; 1;
end case


Gene Ontology [?]

case <FTGroup:1> and <FTGroup:2>
GO:0004089; Molecular function: carbonate dehydratase activity.
end case

case <FTGroup:2> or <FTGroup:3>
GO:0046872; Molecular function: metal ion binding.
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

Metal-binding
Zinc
end case


Features [?]

From: PS51144
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Alpha-carbonic anhydrase #        
ACT_SITE     64     64       Proton acceptor     H   1
BINDING     64     64       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2     H   3
BINDING     67     67       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2     H   3
BINDING     93     93       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic     H   2
BINDING     95     95       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic     H   2
BINDING     118     118       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic     H   2
BINDING     201     201       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2     H   3

Additional information [?]

Size range 15-523 amino acids
Related rules None
Repeats 1-2
Topology Undefined
Example P22748 (CAH4_HUMAN)
Scope
Eukaryota
Viruses; Orthopoxvirus
Bacteria
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


View rule in raw text format (no links)


UniProtKB rule member sequences [?]