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annotation rule: PRU01134

General rule information [?]

Accession PRU01134
Dates 19-APR-2016 (Created)
27-OCT-2018 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS51144; ALPHA_CA_2
Name Alpha-carbonic anhydrase domain
Function Fill in

Propagated annotation [?]


Description [?]

case <FTGroup:1> and <FTGroup:2>
+ AltName: Full=Carbonic anhydrase; EC=4.2.1.1;

Comments [?]

Catalytic activity Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1;.
end case


Cross-references [?]

case <FTGroup:2>
PROSITE PS00162; ALPHA_CA_1; 1;
end case


Gene Ontology [?]

case <FTGroup:1> and <FTGroup:2>
GO:0004089; Molecular function: carbonate dehydratase activity.
end case

case <FTGroup:2> or <FTGroup:3>
GO:0046872; Molecular function: metal ion binding.
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

end case


Features [?]

From: PS51144
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Alpha-carbonic anhydrase #        
ACT_SITE     64     64       Proton acceptor     H   1
METAL     64     64       Zinc #2     H   3
METAL     67     67       Zinc #2     H   3
METAL     93     93       Zinc #1; catalytic     H   2
METAL     95     95       Zinc #1; catalytic     H   2
METAL     118     118       Zinc #1; catalytic     H   2
METAL     201     201       Zinc #2     H   3

Additional information [?]

Size range 15-523 amino acids
Related rules None
Repeats 1-2
Topology Undefined
Example P22748 (CAH4_HUMAN)
Scope
Eukaryota
Viruses; Orthopoxvirus
Bacteria
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]