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ProRule PRU01134


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01134
Accession PRU01134
Dates 19-APR-2016 (Created)
3-SEP-2024 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51144; ALPHA_CA_2
Name Alpha-carbonic anhydrase domain
Function Fill in
Scope(s) Eukaryota
Viruses
Orthopoxvirus
Bacteria
Example(s) P22748 (CAH4_HUMAN);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1> and <FTGroup:2>
Protein name + AltName: Full=Carbonic anhydrase;
                 EC=4.2.1.1;

Comments [?]

CATALYTIC ACTIVITY Reaction=hydrogencarbonate + H(+) = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1;
end case

Keywords [?]

Metal-binding
Zinc
end case

Gene Ontology [?]

case <FTGroup:1> and <FTGroup:2>
GO:0004089; Molecular function:carbonate dehydratase activity
end case
case <FTGroup:2> or <FTGroup:3>
GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding

Cross-references [?]

PROSITE PS00162; ALPHA_CA_1; 1;

Features [?]

From: PS51144
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Alpha-carbonic anhydrase #"
ACT_SITE 64 64 /note="Proton acceptor" H 1
BINDING 64 64 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 H 3
BINDING 67 67 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 H 3
BINDING 93 93 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="catalytic"		 H 2
BINDING 95 95 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="catalytic"		 H 2
BINDING 118 118 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="catalytic"		 H 2
BINDING 201 201 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 H 3

Additional information [?]

Size range 15-523 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]