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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01134


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01134
General rule information [?]

Accession PRU01134
Dates 19-APR-2016 (Created)
03-SEP-2024 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51144; ALPHA_CA_2
Name Alpha-carbonic anhydrase domain
Function Fill in
Scope(s) Eukaryota
Viruses
Orthopoxvirus
Bacteria
Example(s) P22748;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1> and <FTGroup:2>
Protein name + AltName: Full=Carbonic anhydrase;
                 EC=4.2.1.1;

Comments [?]

CATALYTIC ACTIVITY Reaction=hydrogencarbonate + H(+) = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1;
end case

Keywords [?]

Metal-binding
Zinc
end case

Gene Ontology [?]

case <FTGroup:1> and <FTGroup:2>
GO:0004089; Molecular function:carbonate dehydratase activity
end case
case <FTGroup:2> or <FTGroup:3>
GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding

Cross-references [?]

PROSITE PS00162; ALPHA_CA_1; 1;

Features [?]

From: PS51144
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Alpha-carbonic anhydrase #"
ACT_SITE 64 64 /note="Proton acceptor" H 1
BINDING 64 64 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 H 3
BINDING 67 67 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 H 3
BINDING 93 93 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="catalytic"		 H 2
BINDING 95 95 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="catalytic"		 H 2
BINDING 118 118 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="catalytic"		 H 2
BINDING 201 201 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 H 3

Additional information [?]

Size range 15-523 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]