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ProRule PRU01172
General rule information
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| Accession | PRU01172 |
| Dates | 1-FEB-2017 (Created)
19-NOV-2022 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51828; PTX_2 |
Name | Pentraxin (PTX) domain |
| Function | Pentraxins (earlier also termed pentaxins), named for their homopentameric quaternary structure, are a superfamily of multifunctional conserved proteins that are characterized by a cyclic multimeric structure and by the presence in their carboxyl-terminal of an ~200 aa-long conserved domain, called pentraxin (PTX) domain. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q6QNK2 (AGRD1_HUMAN); |
Propagated annotation
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Keywords
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| case <FTGroup:1> or <FTGroup:2> | |
| Calcium | |
| Metal-binding | |
| end case | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Cross-references
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| PROSITE | PS00289; PTX_1; 1; |
Features
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| From: PS51828 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Pentraxin (PTX) #" | |||||||||
| BINDING | 54 | 54 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="#1" |
D | 1 | |||||||
| BINDING | 55 | 55 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="#1" |
N | 1 | |||||||
| BINDING | 133 | 133 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="#1" |
E | 1 | |||||||
| BINDING | 133 | 133 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="#2" |
E | 2 | |||||||
| BINDING | 134 | 134 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="#1" |
Q | 1 | |||||||
| BINDING | 135 | 135 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="#1" |
D | 1 | |||||||
| BINDING | 135 | 135 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="#2" |
D | 2 | |||||||
| BINDING | 145 | 145 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="#2" |
Q | 2 | |||||||
| DISULFID | 32 | 91 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 12-222 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [64] All [ 64 ]
- Retrieve set of proteins with 3D structure for this domain