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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01172


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01172
General rule information [?]

Accession PRU01172
Dates 01-FEB-2017 (Created)
19-NOV-2022 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51828; PTX_2
Name Pentraxin (PTX) domain
Function Pentraxins (earlier also termed pentaxins), named for their homopentameric quaternary structure, are a superfamily of multifunctional conserved proteins that are characterized by a cyclic multimeric structure and by the presence in their carboxyl-terminal of an ~200 aa-long conserved domain, called pentraxin (PTX) domain.
Scope(s) Eukaryota
Metazoa
Example(s) Q6QNK2;

Propagated annotation [?]

Keywords [?]

case <FTGroup:1> or <FTGroup:2>
Calcium
Metal-binding
end case
case <FTTag:disulf>
Disulfide bond
end case

Cross-references [?]

PROSITE PS00289; PTX_1; 1;

Features [?]

From: PS51828
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Pentraxin (PTX) #"
BINDING 54 54 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 D 1
BINDING 55 55 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 N 1
BINDING 133 133 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 E 1
BINDING 133 133 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"		 E 2
BINDING 134 134 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 Q 1
BINDING 135 135 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 D 1
BINDING 135 135 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"		 D 2
BINDING 145 145 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"		 Q 2
DISULFID 32 91 disulf C-x*-C

Additional information [?]

Size range 12-222 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]