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annotation rule: PRU01211

General rule information [?]

Accession PRU01211
Dates 5-JUN-2018 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51864; ASTACIN
Names Astacin-like domain; Peptidase family M12A domain
Function Astacin or M12A family zinc metalloproteases are found in bacteria and animals. They belong to the metzincin protease family and are synthesized as inactive precursors. The zinc atom in these enzymes acts as an electrophilic center to enhance the reactivity of a water molecule prior to nucleophilic attack on the carbonyl carbon of the scissile peptide bond.

Propagated annotation [?]


Comments [?]

case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit
end case


Cross-references [?]

case <FTTag:catalytic> and <FTGroup:1>
PROSITE PS00142; ZINC_PROTEASE; 1;

Gene Ontology [?]

GO:0004222; Molecular function: metalloendopeptidase activity.
end case

case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case


Keywords [?]

case <FTTag:catalytic> and <FTGroup:1>
end case

case <FTGroup:1>
end case

case <FTTag:disulf>
end case


Features [?]

From: PS51864
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase M12A #        
ACT_SITE     95     95           catalytic   E  
METAL     94     94       Zinc; via tele nitrogen; catalytic     H   1
METAL     98     98       Zinc; via tele nitrogen; catalytic     H   1
METAL     104     104       Zinc; via tele nitrogen; catalytic     H   1
DISULFID     5     8           disulf   C-x*-C  
DISULFID     43     198           disulf   C-x*-C  
DISULFID     64     86           disulf   C-x*-C  
DISULFID     66     67           disulf   C-x*-C  

Additional information [?]

Size range 185-215 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P07584 (ASTA_ASTAS)
Scope
Eukaryota
Bacteria
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]