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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01217


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01217
General rule information [?]

Accession PRU01217
Dates 31-JUL-2018 (Created)
19-NOV-2022 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51869; APP_E1
Name Amyloid precursor protein (APP) E1 domain
Function The E1 domain is a cysteine-rich region consisting of a growth factor like subdomain (GFLD), which binds heparin and can stimulate neurite outgrowth, and a copper-binding subdomain (CuBD) that binds Cu and Zn.
Scope(s) Eukaryota
Metazoa
Example(s) P12023;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the APP family.

Keywords [?]

Metal-binding
Copper
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

GO:0008201; Molecular function:heparin binding
case <FTGroup:1>
GO:0046914; Molecular function:transition metal ion binding

Cross-references [?]

PROSITE PS00319; APP_CUBD; 1;

Features [?]

From: PS51869
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="E1 #"
REGION from 94 /note="GFLD subdomain #"
REGION 102 to /note="CuBD subdomain #"
DISULFID 11 34 disulf C-x*-C
DISULFID 45 89 disulf C-x*-C
DISULFID 70 77 disulf C-x*-C
DISULFID 104 158 disulf C-x*-C
DISULFID 129 157 disulf C-x*-C
DISULFID 115 145 disulf C-x*-C
BINDING 118 118 /ligand="Cu(2+)"
/ligand_id="ChEBI:CHEBI:29036"
/ligand_label="#1"		 H 1
BINDING 122 122 /ligand="Cu(2+)"
/ligand_id="ChEBI:CHEBI:29036"
/ligand_label="#1"		 H 1
BINDING 139 139 /ligand="Cu(2+)"
/ligand_id="ChEBI:CHEBI:29036"
/ligand_label="#1"		 Y 1
case <FTGroup:1>
SITE 141 141 /note="Required for Cu(2+) reduction" M
end case

Additional information [?]

Size range 155-175 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]