ProRule PRU01217

PURL	https://purl.expasy.org/prosite/rule/PRU01217
Accession	PRU01217
Dates	31-JUL-2018 (Created) 19-NOV-2022 (Last updated, Version 6)
Data class	Domain;
Predictors	PROSITE; PS51869; APP_E1
Name	Amyloid precursor protein (APP) E1 domain
Function	The E1 domain is a cysteine-rich region consisting of a growth factor like subdomain (GFLD), which binds heparin and can stimulate neurite outgrowth, and a copper-binding subdomain (CuBD) that binds Cu and Zn.
Scope(s)	Eukaryota Metazoa
Example(s)	P12023 (A4_MOUSE);

From: PS51869
Key	From	To	Description	Tag	Condition	FTGroup
DOMAIN	from	to	/note="E1 #"
REGION	from	94	/note="GFLD subdomain #"
REGION	102	to	/note="CuBD subdomain #"
DISULFID	11	34		disulf	C-x*-C
DISULFID	45	89		disulf	C-x*-C
DISULFID	70	77		disulf	C-x*-C
DISULFID	104	158		disulf	C-x*-C
DISULFID	129	157		disulf	C-x*-C
DISULFID	115	145		disulf	C-x*-C
BINDING	118	118	/ligand="Cu(2+)" /ligand_id="ChEBI:CHEBI:29036" /ligand_label="#1"		H	1
BINDING	122	122	/ligand="Cu(2+)" /ligand_id="ChEBI:CHEBI:29036" /ligand_label="#1"		H	1
BINDING	139	139	/ligand="Cu(2+)" /ligand_id="ChEBI:CHEBI:29036" /ligand_label="#1"		Y	1
case <FTGroup:1>
SITE	141	141	/note="Required for Cu(2+) reduction"		M
end case