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annotation rule: PRU01217

General rule information [?]

Accession PRU01217
Dates 31-JUL-2018 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51869; APP_E1
Name Amyloid precursor protein (APP) E1 domain
Function The E1 domain is a cysteine-rich region consisting of a growth factor like subdomain (GFLD), which binds heparin and can stimulate neurite outgrowth, and a copper-binding subdomain (CuBD) that binds Cu and Zn.

Propagated annotation [?]

Comments [?]

Similarity Belongs to the APP family.

Cross-references [?]


Gene Ontology [?]

GO:0008201; Molecular function: heparin binding.
case <FTGroup:1>
GO:0046914; Molecular function: transition metal ion binding.

Keywords [?]

end case

case <FTTag:disulf>
end case

Features [?]

From: PS51869
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       E1 #        
REGION     from     94       GFLD subdomain #        
REGION     102     to       CuBD subdomain #        
DISULFID     11     34           disulf   C-x*-C  
DISULFID     45     89           disulf   C-x*-C  
DISULFID     70     77           disulf   C-x*-C  
DISULFID     104     158           disulf   C-x*-C  
DISULFID     129     157           disulf   C-x*-C  
DISULFID     115     145           disulf   C-x*-C  
METAL     118     118       Copper #1     H   1
METAL     122     122       Copper #1     H   1
METAL     139     139       Copper #1     Y   1
case <FTGroup:1>
SITE     141     141       Required for Cu(2+) reduction     M  
end case

Additional information [?]

Size range 155-175 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P12023 (A4_MOUSE)
Eukaryota; Metazoa
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]