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ProRule PRU01217


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PURL: https://purl.expasy.org/prosite/rule/PRU01217
General rule information [?]

Accession PRU01217
Dates 31-JUL-2018 (Created)
19-NOV-2022 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS51869; APP_E1
Name Amyloid precursor protein (APP) E1 domain
Function The E1 domain is a cysteine-rich region consisting of a growth factor like subdomain (GFLD), which binds heparin and can stimulate neurite outgrowth, and a copper-binding subdomain (CuBD) that binds Cu and Zn.
Scope(s) Eukaryota
Metazoa
Example(s) P12023;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the APP family.

Keywords [?]

Metal-binding
Copper
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

GO:0008201; Molecular function:heparin binding
case <FTGroup:1>
GO:0046914; Molecular function:transition metal ion binding

Cross-references [?]

PROSITE PS00319; APP_CUBD; 1;

Features [?]

From: PS51869
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="E1 #"
REGION from 94 /note="GFLD subdomain #"
REGION 102 to /note="CuBD subdomain #"
DISULFID 11 34 disulf C-x*-C
DISULFID 45 89 disulf C-x*-C
DISULFID 70 77 disulf C-x*-C
DISULFID 104 158 disulf C-x*-C
DISULFID 129 157 disulf C-x*-C
DISULFID 115 145 disulf C-x*-C
BINDING 118 118 /ligand="Cu(2+)"
/ligand_id="ChEBI:CHEBI:29036"
/ligand_label="#1"		 H 1
BINDING 122 122 /ligand="Cu(2+)"
/ligand_id="ChEBI:CHEBI:29036"
/ligand_label="#1"		 H 1
BINDING 139 139 /ligand="Cu(2+)"
/ligand_id="ChEBI:CHEBI:29036"
/ligand_label="#1"		 Y 1
case <FTGroup:1>
SITE 141 141 /note="Required for Cu(2+) reduction" M
end case

Additional information [?]

Size range 155-175 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]