General rule information
[?]
Accession |
PRU01217 |
Dates |
31-JUL-2018 (Created) 22-NOV-2019 (Last updated, Version 3) |
Predictors |
PROSITE; PS51869; APP_E1
|
Name |
Amyloid precursor protein (APP) E1 domain |
Function |
The E1 domain is a cysteine-rich region consisting of a growth factor like subdomain (GFLD), which binds heparin and can stimulate neurite outgrowth, and a copper-binding subdomain (CuBD) that binds Cu and Zn. |
Propagated annotation
[?]
Similarity |
Belongs to the APP family. |
case <FTGroup:1>
GO:0046914; Molecular function: transition metal ion binding.
end case
case <FTTag:disulf>
end case
From: PS51869 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
E1 #
|
|
|
|
|
|
|
REGION
|
|
from
|
|
94
|
|
GFLD subdomain #
|
|
|
|
|
|
|
REGION
|
|
102
|
|
to
|
|
CuBD subdomain #
|
|
|
|
|
|
|
DISULFID
|
|
11
|
|
34
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
45
|
|
89
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
70
|
|
77
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
104
|
|
158
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
129
|
|
157
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
115
|
|
145
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
METAL
|
|
118
|
|
118
|
|
Copper #1
|
|
|
|
H
|
|
1
|
METAL
|
|
122
|
|
122
|
|
Copper #1
|
|
|
|
H
|
|
1
|
METAL
|
|
139
|
|
139
|
|
Copper #1
|
|
|
|
Y
|
|
1
|
case <FTGroup:1>
SITE
|
|
141
|
|
141
|
|
Required for Cu(2+) reduction
|
|
|
|
M
|
|
|
end case
Additional information
[?]
Size range |
155-175 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
P12023 (A4_MOUSE) |
Scope |
Eukaryota; Metazoa |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]