ProRule PRU01222
General rule information
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Accession | PRU01222 |
Dates | 18-JAN-2019 (Created)
22-NOV-2019 (Last updated, Version 3) |
Data class | Domain; |
Predictors |
PROSITE; PS51874; PCV_3C_PRO |
Name | Picornavirales 3C/3C-like protease domain |
Function | The 3C (for the family Picornaviridae) or 3C-like (3CL) protease (for other families) plays a central role in the cleavage of the viral precursor polyprotein. In addition to its key role in processing the polyprotein, 3C/3C-like protease is able to cleave a number of host proteins to remodel the cellular environment for virus reproduction. |
Scope(s) |
Viruses Riboviria |
Example(s) | P06209 (POLG_POL32); |
Propagated annotation
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Identifier, protein and gene names
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case <FTGroup:1> or <FTGroup:2> | |
Protein name | Contains: RecName: Full=Protease 3C; EC=3.4.22.28; AltName: Full=Picornain 3C; Short=P3C; |
else case <FTGroup:3> | |
Protein name | Contains: RecName: Full=Picornain 3C-like protease; EC=3.4.22.-; Short=3C-like protease; |
else case <FTGroup:4> | |
Protein name | Contains: RecName: Full=3C-like protease; EC=3.4.22.-; Short=3CL-PRO; |
end case |
Comments
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case <FTGroup:1> or <FTGroup:2> | |
CATALYTIC ACTIVITY | Reaction=Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.; EC=3.4.22.28; |
end case |
Keywords
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Hydrolase | |
Protease | |
Thiol protease | |
end case |
Gene Ontology
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case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> | |
GO:0004197; Molecular function:cysteine-type endopeptidase activity |
Features
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From: PS51874 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="Peptidase C3 #" | |||||||||
case <OS:Foot-and-mouth disease virus> | ||||||||||||
ACT_SITE | 41 | 41 | /note="For protease 3C activity; Proton donor/acceptor" | H | 1 | |||||||
ACT_SITE | 78 | 78 | /note="For protease 3C activity" | [ED] | 1 | |||||||
ACT_SITE | 164 | 164 | /note="For protease 3C activity" | C | 1 | |||||||
else case <OC:Picornaviridae> | ||||||||||||
ACT_SITE | 41 | 41 | /note="For protease 3C activity" | H | 2 | |||||||
ACT_SITE | 78 | 78 | /note="For protease 3C activity" | [ED] | 2 | |||||||
ACT_SITE | 164 | 164 | /note="For protease 3C activity" | C | 2 | |||||||
else case <OC:Picornavirales> | ||||||||||||
ACT_SITE | 41 | 41 | /note="For picornain 3C-like protease activity" | H | 3 | |||||||
ACT_SITE | 78 | 78 | /note="For picornain 3C-like protease activity" | [ED] | 3 | |||||||
ACT_SITE | 164 | 164 | /note="For picornain 3C-like protease activity" | C | 3 | |||||||
else | ||||||||||||
ACT_SITE | 41 | 41 | /note="For 3C-like protease activity" | H | 4 | |||||||
ACT_SITE | 78 | 78 | /note="For 3C-like protease activity" | [ED] | 4 | |||||||
ACT_SITE | 164 | 164 | /note="For 3C-like protease activity" | C | 4 | |||||||
end case |
Additional information
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Size range | 170-250 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [119] All [ 119 ]
- Retrieve set of proteins with 3D structure for this domain