ProRule PRU01222

General rule information [?]

Accession PRU01222
Dates 18-JAN-2019 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51874; PCV_3C_PRO
Name Picornavirales 3C/3C-like protease domain
Function The 3C (for the family Picornaviridae) or 3C-like (3CL) protease (for other families) plays a central role in the cleavage of the viral precursor polyprotein. In addition to its key role in processing the polyprotein, 3C/3C-like protease is able to cleave a number of host proteins to remodel the cellular environment for virus reproduction.
Scope(s) Viruses
Example(s) P06209 (POLG_POL32);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1> or <FTGroup:2>
Protein name Contains:
RecName: Full=Protease 3C;
AltName: Full=Picornain 3C;
else case <FTGroup:3>
Protein name Contains:
RecName: Full=Picornain 3C-like protease;
                 Short=3C-like protease;
else case <FTGroup:4>
Protein name Contains:
RecName: Full=3C-like protease;
end case

Comments [?]

case <FTGroup:1> or <FTGroup:2>
CATALYTIC ACTIVITY Reaction=Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.; EC=;
end case

Keywords [?]

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4>
GO:0004197; Molecular function:cysteine-type endopeptidase activity

Features [?]

From: PS51874
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C3 #"
case <OS:Foot-and-mouth disease virus>
ACT_SITE 41 41 /note="For protease 3C activity; Proton donor/acceptor" H 1
ACT_SITE 78 78 /note="For protease 3C activity" [ED] 1
ACT_SITE 164 164 /note="For protease 3C activity" C 1
else case <OC:Picornaviridae>
ACT_SITE 41 41 /note="For protease 3C activity" H 2
ACT_SITE 78 78 /note="For protease 3C activity" [ED] 2
ACT_SITE 164 164 /note="For protease 3C activity" C 2
else case <OC:Picornavirales>
ACT_SITE 41 41 /note="For picornain 3C-like protease activity" H 3
ACT_SITE 78 78 /note="For picornain 3C-like protease activity" [ED] 3
ACT_SITE 164 164 /note="For picornain 3C-like protease activity" C 3
ACT_SITE 41 41 /note="For 3C-like protease activity" H 4
ACT_SITE 78 78 /note="For 3C-like protease activity" [ED] 4
ACT_SITE 164 164 /note="For 3C-like protease activity" C 4
end case

Additional information [?]

Size range 170-250 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]