General rule information
[?]
Accession |
PRU01222 |
Dates |
18-JAN-2019 (Created) 22-NOV-2019 (Last updated, Version 3) |
Predictors |
PROSITE; PS51874; PCV_3C_PRO
|
Name |
Picornavirales 3C/3C-like protease domain |
Function |
The 3C (for the family Picornaviridae) or 3C-like (3CL) protease (for other families) plays a central role in the cleavage of the viral precursor polyprotein. In addition to its key role in processing the polyprotein, 3C/3C-like protease is able to cleave a number of host proteins to remodel the cellular environment for virus reproduction. |
Propagated annotation
[?]
case <FTGroup:1> or <FTGroup:2>
Contains:
RecName: Full=Protease 3C;
EC 3.4.22.28;
AltName: Full=Picornain 3C;
Short=P3C; |
else case <FTGroup:3>
Contains:
RecName: Full=Picornain 3C-like protease;
EC 3.4.22.-;
Short=3C-like protease; |
else case <FTGroup:4>
Contains:
RecName: Full=3C-like protease;
EC 3.4.22.-;
Short=3CL-PRO; |
end case
case <FTGroup:1> or <FTGroup:2>
Catalytic activity |
Reaction=Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.; EC=3.4.22.28; |
end case
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4>
GO:0004197; Molecular function: cysteine-type endopeptidase activity.
end case
From: PS51874 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
Peptidase C3 #
|
|
|
|
|
|
|
case <OS:Foot-and-mouth disease virus>
ACT_SITE
|
|
41
|
|
41
|
|
For protease 3C activity; Proton donor/acceptor
|
|
|
|
H
|
|
1
|
ACT_SITE
|
|
78
|
|
78
|
|
For protease 3C activity
|
|
|
|
[ED]
|
|
1
|
ACT_SITE
|
|
164
|
|
164
|
|
For protease 3C activity
|
|
|
|
C
|
|
1
|
else case <OC:Picornaviridae>
ACT_SITE
|
|
41
|
|
41
|
|
For protease 3C activity
|
|
|
|
H
|
|
2
|
ACT_SITE
|
|
78
|
|
78
|
|
For protease 3C activity
|
|
|
|
[ED]
|
|
2
|
ACT_SITE
|
|
164
|
|
164
|
|
For protease 3C activity
|
|
|
|
C
|
|
2
|
else case <OC:Picornavirales>
ACT_SITE
|
|
41
|
|
41
|
|
For picornain 3C-like protease activity
|
|
|
|
H
|
|
3
|
ACT_SITE
|
|
78
|
|
78
|
|
For picornain 3C-like protease activity
|
|
|
|
[ED]
|
|
3
|
ACT_SITE
|
|
164
|
|
164
|
|
For picornain 3C-like protease activity
|
|
|
|
C
|
|
3
|
else
ACT_SITE
|
|
41
|
|
41
|
|
For 3C-like protease activity
|
|
|
|
H
|
|
4
|
ACT_SITE
|
|
78
|
|
78
|
|
For 3C-like protease activity
|
|
|
|
[ED]
|
|
4
|
ACT_SITE
|
|
164
|
|
164
|
|
For 3C-like protease activity
|
|
|
|
C
|
|
4
|
end case
Additional information
[?]
Size range |
170-250 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
P06209 (POLG_POL32) |
Scope |
Viruses; Riboviria |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]