ProRule PRU01222

Accession	PRU01222
Dates	18-JAN-2019 (Created) 22-NOV-2019 (Last updated, Version 3)
Data class	Domain;
Predictors	PROSITE; PS51874; PCV_3C_PRO
Name	Picornavirales 3C/3C-like protease domain
Function	The 3C (for the family Picornaviridae) or 3C-like (3CL) protease (for other families) plays a central role in the cleavage of the viral precursor polyprotein. In addition to its key role in processing the polyprotein, 3C/3C-like protease is able to cleave a number of host proteins to remodel the cellular environment for virus reproduction.
Scope(s)	Viruses Riboviria
Example(s)	P06209 (POLG_POL32);

From: PS51874
Key	From	To	Description	Tag	Condition	FTGroup
DOMAIN	from	to	/note="Peptidase C3 #"
case <OS:Foot-and-mouth disease virus>
ACT_SITE	41	41	/note="For protease 3C activity; Proton donor/acceptor"		H	1
ACT_SITE	78	78	/note="For protease 3C activity"		[ED]	1
ACT_SITE	164	164	/note="For protease 3C activity"		C	1
else case <OC:Picornaviridae>
ACT_SITE	41	41	/note="For protease 3C activity"		H	2
ACT_SITE	78	78	/note="For protease 3C activity"		[ED]	2
ACT_SITE	164	164	/note="For protease 3C activity"		C	2
else case <OC:Picornavirales>
ACT_SITE	41	41	/note="For picornain 3C-like protease activity"		H	3
ACT_SITE	78	78	/note="For picornain 3C-like protease activity"		[ED]	3
ACT_SITE	164	164	/note="For picornain 3C-like protease activity"		C	3
else
ACT_SITE	41	41	/note="For 3C-like protease activity"		H	4
ACT_SITE	78	78	/note="For 3C-like protease activity"		[ED]	4
ACT_SITE	164	164	/note="For 3C-like protease activity"		C	4
end case