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annotation rule: PRU01222

General rule information [?]

Accession PRU01222
Dates 18-JAN-2019 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51874; PCV_3C_PRO
Name Picornavirales 3C/3C-like protease domain
Function The 3C (for the family Picornaviridae) or 3C-like (3CL) protease (for other families) plays a central role in the cleavage of the viral precursor polyprotein. In addition to its key role in processing the polyprotein, 3C/3C-like protease is able to cleave a number of host proteins to remodel the cellular environment for virus reproduction.

Propagated annotation [?]


Description [?]

case <FTGroup:1> or <FTGroup:2>
Contains: RecName: Full=Protease 3C; EC 3.4.22.28; AltName: Full=Picornain 3C; Short=P3C;
else case <FTGroup:3>
Contains: RecName: Full=Picornain 3C-like protease; EC 3.4.22.-; Short=3C-like protease;
else case <FTGroup:4>
Contains: RecName: Full=3C-like protease; EC 3.4.22.-; Short=3CL-PRO;
end case


Comments [?]

case <FTGroup:1> or <FTGroup:2>
Catalytic activity Reaction=Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.; EC=3.4.22.28;
end case


Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4>
GO:0004197; Molecular function: cysteine-type endopeptidase activity.

Keywords [?]

Hydrolase
Protease
Thiol protease
end case


Features [?]

From: PS51874
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase C3 #        
case <OS:Foot-and-mouth disease virus>
ACT_SITE     41     41       For protease 3C activity; Proton donor/acceptor     H   1
ACT_SITE     78     78       For protease 3C activity     [ED]   1
ACT_SITE     164     164       For protease 3C activity     C   1
else case <OC:Picornaviridae>
ACT_SITE     41     41       For protease 3C activity     H   2
ACT_SITE     78     78       For protease 3C activity     [ED]   2
ACT_SITE     164     164       For protease 3C activity     C   2
else case <OC:Picornavirales>
ACT_SITE     41     41       For picornain 3C-like protease activity     H   3
ACT_SITE     78     78       For picornain 3C-like protease activity     [ED]   3
ACT_SITE     164     164       For picornain 3C-like protease activity     C   3
else
ACT_SITE     41     41       For 3C-like protease activity     H   4
ACT_SITE     78     78       For 3C-like protease activity     [ED]   4
ACT_SITE     164     164       For 3C-like protease activity     C   4
end case


Additional information [?]

Size range 170-250 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P06209 (POLG_POL32)
Scope
Viruses; Riboviria
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]