PRU01225

Accession	PRU01225
Dates	5-NOV-2018 (Created) 22-NOV-2019 (Last updated, Version 3)

Data class

Domain

Predictors

PROSITE; PS51877; HAV_P29_PRO

Names

Hypovirulence-associated virus (HAV) papain-like protease p29 domain; Peptidase C7 domain

Function

The HAV papain-like protease p29 is a cysteine protease, which forms the peptidase family C7. A Cys and a His catalytic residue are essential for autocatalytic cleavage at a glycine dipeptide clevage site located at the C- terminus of the domain.

+ Contains: RecName: Full=Papain-like protease p29; EC 3.4.22.-;

Function

Papain-like protease p29 is a cysteine protease of the peptidase family C7 that contributes to hypovirulence-associated traits like the reduction in conidiation and laccase activity, but not to virulence attenuation. Acts as suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of viral defense that limits the accumulation of viral RNAs. Enhances viral dsRNA accumulation and virus transmission. Also involved in the reduction in orange pigmentation of the host, an effect independent of the intrinsic protease activity.

GO:0008234; Molecular function: cysteine-type peptidase activity.

Hydrolase
Protease
Thiol protease

From: PS51877

Key

From

To

Description

Tag

Condition

FTGroup

DOMAIN

from

to

Peptidase C7 #

ACT_SITE

142

142

For papain-like protease p29 activity

C

1

ACT_SITE

195

195

For papain-like protease p29 activity

H

1

SITE

to

to+1

Cleavage; by papain-like protease p29

G-x

Size range	245-255 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	P10941 (POLA_CHPVE)
Scope	Viruses; Hypovirus
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB/Swiss-Prot sets

Viruses

[2]