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annotation rule: PRU01225

General rule information [?]

Accession PRU01225
Dates 5-NOV-2018 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51877; HAV_P29_PRO
Names Hypovirulence-associated virus (HAV) papain-like protease p29 domain; Peptidase C7 domain
Function The HAV papain-like protease p29 is a cysteine protease, which forms the peptidase family C7. A Cys and a His catalytic residue are essential for autocatalytic cleavage at a glycine dipeptide clevage site located at the C- terminus of the domain.

Propagated annotation [?]


Description [?]

case <FTGroup:1>
+ Contains: RecName: Full=Papain-like protease p29; EC 3.4.22.-;

Comments [?]

Function Papain-like protease p29 is a cysteine protease of the peptidase family C7 that contributes to hypovirulence-associated traits like the reduction in conidiation and laccase activity, but not to virulence attenuation. Acts as suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of viral defense that limits the accumulation of viral RNAs. Enhances viral dsRNA accumulation and virus transmission. Also involved in the reduction in orange pigmentation of the host, an effect independent of the intrinsic protease activity.

Gene Ontology [?]

GO:0008234; Molecular function: cysteine-type peptidase activity.

Keywords [?]

end case


Features [?]

From: PS51877
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase C7 #        
ACT_SITE     142     142       For papain-like protease p29 activity     C   1
ACT_SITE     195     195       For papain-like protease p29 activity     H   1
SITE     to     to+1       Cleavage; by papain-like protease p29     G-x  

Additional information [?]

Size range 245-255 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P10941 (POLA_CHPVE)
Scope
Viruses; Hypovirus
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Viruses [2]