We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01225
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01225
General rule information
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| Accession | PRU01225 |
| Dates | 05-NOV-2018 (Created)
22-NOV-2019 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51877; HAV_P29_PRO |
Name | Hypovirulence-associated virus (HAV) papain-like protease p29 domain |
| Function | The HAV papain-like protease p29 is a cysteine protease, which forms the peptidase family C7. A Cys and a His catalytic residue are essential for autocatalytic cleavage at a glycine dipeptide clevage site located at the C- terminus of the domain. |
| Scope(s) |
Viruses Hypovirus |
| Example(s) | P10941; |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> | |
| Protein name | + Contains: RecName: Full=Papain-like protease p29; EC=3.4.22.-; |
Comments
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| FUNCTION | Papain-like protease p29 is a cysteine protease of the peptidase family C7 that contributes to hypovirulence-associated traits like the reduction in conidiation and laccase activity, but not to virulence attenuation. Acts as suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of viral defense that limits the accumulation of viral RNAs. Enhances viral dsRNA accumulation and virus transmission. Also involved in the reduction in orange pigmentation of the host, an effect independent of the intrinsic protease activity. |
Keywords
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| Hydrolase | |
| Protease | |
| Thiol protease | |
| end case | |
Gene Ontology
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| GO:0008234; Molecular function:cysteine-type peptidase activity |
Features
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| From: PS51877 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase C7 #" | |||||||||
| ACT_SITE | 142 | 142 | /note="For papain-like protease p29 activity" | C | 1 | |||||||
| ACT_SITE | 195 | 195 | /note="For papain-like protease p29 activity" | H | 1 | |||||||
| SITE | to | to+1 | /note="Cleavage; by papain-like protease p29" | G-x | ||||||||
Additional information
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| Size range | 245-255 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [2] All [ 2 ]
- Retrieve set of proteins with 3D structure for this domain