ProRule PRU01225

General rule information [?]

Accession PRU01225
Dates 5-NOV-2018 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51877; HAV_P29_PRO
Name Hypovirulence-associated virus (HAV) papain-like protease p29 domain
Function The HAV papain-like protease p29 is a cysteine protease, which forms the peptidase family C7. A Cys and a His catalytic residue are essential for autocatalytic cleavage at a glycine dipeptide clevage site located at the C- terminus of the domain.
Scope(s) Viruses
Example(s) P10941 (POLA_CHPVE);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + Contains:
RecName: Full=Papain-like protease p29;

Comments [?]

FUNCTIONPapain-like protease p29 is a cysteine protease of the peptidase family C7 that contributes to hypovirulence-associated traits like the reduction in conidiation and laccase activity, but not to virulence attenuation. Acts as suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of viral defense that limits the accumulation of viral RNAs. Enhances viral dsRNA accumulation and virus transmission. Also involved in the reduction in orange pigmentation of the host, an effect independent of the intrinsic protease activity.

Keywords [?]

Gene Ontology [?]

GO:0008234; Molecular function:cysteine-type peptidase activity

Features [?]

From: PS51877
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C7 #"
ACT_SITE 142 142 /note="For papain-like protease p29 activity" C 1
ACT_SITE 195 195 /note="For papain-like protease p29 activity" H 1
SITE to to+1 /note="Cleavage; by papain-like protease p29" G-x

Additional information [?]

Size range 245-255 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]