ProRule PRU01235
General rule information
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Accession | PRU01235 |
Dates | 21-MAR-2019 (Created)
1-MAR-2024 (Last updated, Version 11) |
Data class | Domain; |
Predictors |
PROSITE; PS51887; APHTHOVIRUS_LPRO |
Name | Aphthovirus leader protease (L(pro)) domain |
Function | Aphthovirus L(pro) is a papain-like proteinase that self-cleaves from the nascent viral polyprotein precursor during infection and plays an important role in viral pathogenesis. L(pro) is known to contribute to virus propagation by suppressing host antiviral activity. L(pro) has an antagonistic effect on host antiviral responses via at least three mechanisms. |
Scope(s) |
Viruses Aphthovirus |
Example(s) | P03311 (POLG_FMDVS); |
Propagated annotation
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Keywords
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Gene Ontology
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case <FTGroup:1> | |
GO:0039579; Biological process:symbiont-mediated suppression of host ISG15-protein conjugation | |
GO:0019049; Biological process:virus-mediated perturbation of host defense response | |
GO:0052170; Biological process:symbiont-mediated suppression of host innate immune response | |
GO:0039502; Biological process:symbiont-mediated suppression of host type I interferon-mediated signaling pathway |
Features
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From: PS51887 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="Peptidase C28 #" | |||||||||
ACT_SITE | 23 | 23 | /note="For leader protease activity" | C | 1 | |||||||
ACT_SITE | 120 | 120 | /note="For leader protease activity" | H | 1 | |||||||
ACT_SITE | 135 | 135 | /note="For leader protease activity" | D | 1 |
Additional information
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Size range | 150-160 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [12] All [ 12 ]
- Retrieve set of proteins with 3D structure for this domain