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| annotation rule: PRU01235 |
General rule information
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| Accession | PRU01235 |
| Dates | 21-MAR-2019 (Created) 23-JAN-2020 (Last updated, Version 5) |
| Data class | Domain |
| Predictors | PROSITE; PS51887; APHTHOVIRUS_LPRO |
| Names | Aphthovirus leader protease (L(pro)) domain; Peptidase C28 domain |
| Function | Aphthovirus L(pro) is a papain-like proteinase that self-cleaves from the nascent viral polyprotein precursor during infection and plays an important role in viral pathogenesis. L(pro) is known to contribute to virus propagation by suppressing host antiviral activity. L(pro) has an antagonistic effect on host antiviral responses via at least three mechanisms. |
Propagated annotation
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Gene Ontology
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case <FTGroup:1>
GO:0039648; Biological process: modulation by virus of host protein ubiquitination.
GO:0039579; Biological process: suppression by virus of host ISG15 activity.
GO:0030683; Biological process: mitigation of host immune response by virus.
GO:0039503; Biological process: suppression by virus of host innate immune response.
GO:0039502; Biological process: suppression by virus of host type I interferon-mediated signaling pathway.
GO:0039579; Biological process: suppression by virus of host ISG15 activity.
GO:0030683; Biological process: mitigation of host immune response by virus.
GO:0039503; Biological process: suppression by virus of host innate immune response.
GO:0039502; Biological process: suppression by virus of host type I interferon-mediated signaling pathway.
Keywords
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Hydrolase
Protease
Thiol protease
Modulation of host ubiquitin pathway by virus
Modulation of host ubiquitin pathway by viral deubiquitinase
Inhibition of host ISG15 by virus
Viral immunoevasion
Inhibition of host innate immune response by virus
Inhibition of host interferon signaling pathway by virus
Protease
Thiol protease
Modulation of host ubiquitin pathway by virus
Modulation of host ubiquitin pathway by viral deubiquitinase
Inhibition of host ISG15 by virus
Viral immunoevasion
Inhibition of host innate immune response by virus
Inhibition of host interferon signaling pathway by virus
end case
Features
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| From: PS51887 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | Peptidase C28 # | |||||||||
| ACT_SITE | 23 | 23 | For leader protease activity | C | 1 | |||||||
| ACT_SITE | 120 | 120 | For leader protease activity | H | 1 | |||||||
| ACT_SITE | 135 | 135 | For leader protease activity | D | 1 | |||||||
Additional information
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| Size range | 150-160 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P03311 (POLG_FMDVS) |
| Scope | Viruses; Aphthovirus |
| Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Viruses [9]
- Retrieve set of proteins with 3D structure for this domain