ProRule PRU01235

General rule information [?]

Accession PRU01235
Dates 21-MAR-2019 (Created)
1-MAR-2024 (Last updated, Version 11)
Data class Domain;
Name Aphthovirus leader protease (L(pro)) domain
Function Aphthovirus L(pro) is a papain-like proteinase that self-cleaves from the nascent viral polyprotein precursor during infection and plays an important role in viral pathogenesis. L(pro) is known to contribute to virus propagation by suppressing host antiviral activity. L(pro) has an antagonistic effect on host antiviral responses via at least three mechanisms.
Scope(s) Viruses
Example(s) P03311 (POLG_FMDVS);

Propagated annotation [?]

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0039579; Biological process:symbiont-mediated suppression of host ISG15-protein conjugation
GO:0019049; Biological process:virus-mediated perturbation of host defense response
GO:0052170; Biological process:symbiont-mediated suppression of host innate immune response
GO:0039502; Biological process:symbiont-mediated suppression of host type I interferon-mediated signaling pathway

Features [?]

From: PS51887
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C28 #"
ACT_SITE 23 23 /note="For leader protease activity" C 1
ACT_SITE 120 120 /note="For leader protease activity" H 1
ACT_SITE 135 135 /note="For leader protease activity" D 1

Additional information [?]

Size range 150-160 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]