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annotation rule: PRU01235 |
Accession | PRU01235 |
Dates | 21-MAR-2019 (Created) 23-JAN-2020 (Last updated, Version 5) |
Data class | Domain |
Predictors | PROSITE; PS51887; APHTHOVIRUS_LPRO |
Names | Aphthovirus leader protease (L(pro)) domain; Peptidase C28 domain |
Function | Aphthovirus L(pro) is a papain-like proteinase that self-cleaves from the nascent viral polyprotein precursor during infection and plays an important role in viral pathogenesis. L(pro) is known to contribute to virus propagation by suppressing host antiviral activity. L(pro) has an antagonistic effect on host antiviral responses via at least three mechanisms. |
From: PS51887 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | Peptidase C28 # | |||||||||
ACT_SITE | 23 | 23 | For leader protease activity | C | 1 | |||||||
ACT_SITE | 120 | 120 | For leader protease activity | H | 1 | |||||||
ACT_SITE | 135 | 135 | For leader protease activity | D | 1 |
Size range | 150-160 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | P03311 (POLG_FMDVS) |
Scope | Viruses; Aphthovirus |
Comments | None |
Viruses | [9] |