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annotation rule: PRU01235

General rule information [?]

Accession PRU01235
Dates 21-MAR-2019 (Created)
23-JAN-2020 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS51887; APHTHOVIRUS_LPRO
Names Aphthovirus leader protease (L(pro)) domain; Peptidase C28 domain
Function Aphthovirus L(pro) is a papain-like proteinase that self-cleaves from the nascent viral polyprotein precursor during infection and plays an important role in viral pathogenesis. L(pro) is known to contribute to virus propagation by suppressing host antiviral activity. L(pro) has an antagonistic effect on host antiviral responses via at least three mechanisms.

Propagated annotation [?]


Gene Ontology [?]

case <FTGroup:1>
GO:0039648; Biological process: modulation by virus of host protein ubiquitination.
GO:0039579; Biological process: suppression by virus of host ISG15 activity.
GO:0030683; Biological process: mitigation of host immune response by virus.
GO:0039503; Biological process: suppression by virus of host innate immune response.
GO:0039502; Biological process: suppression by virus of host type I interferon-mediated signaling pathway.

Keywords [?]

end case


Features [?]

From: PS51887
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase C28 #        
ACT_SITE     23     23       For leader protease activity     C   1
ACT_SITE     120     120       For leader protease activity     H   1
ACT_SITE     135     135       For leader protease activity     D   1

Additional information [?]

Size range 150-160 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P03311 (POLG_FMDVS)
Scope
Viruses; Aphthovirus
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]