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ProRule PRU01235


General rule information [?]

Accession PRU01235
Dates 21-MAR-2019 (Created)
13-FEB-2023 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51887; APHTHOVIRUS_LPRO
Name Aphthovirus leader protease (L(pro)) domain
Function Aphthovirus L(pro) is a papain-like proteinase that self-cleaves from the nascent viral polyprotein precursor during infection and plays an important role in viral pathogenesis. L(pro) is known to contribute to virus propagation by suppressing host antiviral activity. L(pro) has an antagonistic effect on host antiviral responses via at least three mechanisms.
Scope(s) Viruses
Aphthovirus
Example(s) P03311 (POLG_FMDVS);

Propagated annotation [?]

Keywords [?]

Hydrolase
Protease
Thiol protease
Modulation of host ubiquitin pathway by virus
Modulation of host ubiquitin pathway by viral deubiquitinase
Inhibition of host ISG15 by virus
Viral immunoevasion
Inhibition of host innate immune response by virus
Inhibition of host interferon signaling pathway by virus
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0039579; Biological process:suppression by virus of host ISG15-protein conjugation
GO:0019049; Biological process:mitigation of host antiviral defense response
GO:0039503; Biological process:suppression by virus of host innate immune response
GO:0039502; Biological process:suppression by virus of host type I interferon-mediated signaling pathway

Features [?]

From: PS51887
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C28 #"
ACT_SITE 23 23 /note="For leader protease activity" C 1
ACT_SITE 120 120 /note="For leader protease activity" H 1
ACT_SITE 135 135 /note="For leader protease activity" D 1

Additional information [?]

Size range 150-160 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]