We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01240
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01240
General rule information
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| Accession | PRU01240 |
| Dates | 23-MAY-2019 (Created)
08-OCT-2024 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51892; SUBTILASE |
Name | Serine proteases, subtilase domain |
| Function | Subtilases are an extensive family of serine proteases which occur in Archaea, Bacteria, fungi, yeasts, and higher eukaryotes. Their catalytic activity is provided by a charge relay system similar to that of the trypsin family of serine proteases but which evolved by independent convergent evolution. |
| Scope(s) |
Eukaryota Bacteria Archaea Methanobacteriati |
| Example(s) | B8N106; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the peptidase S8 family. |
Keywords
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| Hydrolase | |
| Protease | |
| Serine protease | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0004252; Molecular function:serine-type endopeptidase activity | |
Cross-references
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| PROSITE | PS00136; SUBTILASE_ASP; 1; |
| PROSITE | PS00137; SUBTILASE_HIS; 1; |
| PROSITE | PS00138; SUBTILASE_SER; 1; |
Features
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| From: PS51892 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase S8 #" | |||||||||
| ACT_SITE | 31 | 31 | /note="Charge relay system" | D | 1 | |||||||
| ACT_SITE | 66 | 66 | /note="Charge relay system" | H | 1 | |||||||
| ACT_SITE | 230 | 230 | /note="Charge relay system" | S | 1 | |||||||
Additional information
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| Size range | 240-560 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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