ProRule PRU01240
General rule information
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| Accession | PRU01240 |
| Dates | 23-MAY-2019 (Created)
8-OCT-2024 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51892; SUBTILASE |
Name | Serine proteases, subtilase domain |
| Function | Subtilases are an extensive family of serine proteases which occur in Archaea, Bacteria, fungi, yeasts, and higher eukaryotes. Their catalytic activity is provided by a charge relay system similar to that of the trypsin family of serine proteases but which evolved by independent convergent evolution. |
| Scope(s) |
Eukaryota Bacteria Archaea Methanobacteriati |
| Example(s) | B8N106 (ORYZ_ASPFN); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the peptidase S8 family. |
Keywords
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| Hydrolase | |
| Protease | |
| Serine protease | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0004252; Molecular function:serine-type endopeptidase activity | |
Cross-references
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| PROSITE | PS00136; SUBTILASE_ASP; 1; |
| PROSITE | PS00137; SUBTILASE_HIS; 1; |
| PROSITE | PS00138; SUBTILASE_SER; 1; |
Features
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| From: PS51892 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase S8 #" | |||||||||
| ACT_SITE | 31 | 31 | /note="Charge relay system" | D | 1 | |||||||
| ACT_SITE | 66 | 66 | /note="Charge relay system" | H | 1 | |||||||
| ACT_SITE | 230 | 230 | /note="Charge relay system" | S | 1 | |||||||
Additional information
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| Size range | 240-560 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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