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General rule information [?]

Accession PRU01258
Dates 5-NOV-2019 (Created)
19-NOV-2022 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS51910; GH18_2
Name Glycosyl hydrolases family 18 (GH18) domain
Function The GH18 family contains hydrolytic enzymes with chitinase or endo- N-acetyl-beta-D-glucosaminidase (ENGase) activity as well as chitinase like lectins (chi-lectins/proteins (CLPs). Chitinases (EC are hydrolytic enzymes that cleave the beta-1,4-bond releasing oligomeric, dimeric (chitobiose) or monomeric (N-actetylglucosamine, GlcNAc) products. ENGases (EC hydrolyze the beta-1,4 linkage in the chitobiose core of N- linked glycans from glycoproteins leaving one GlcNAc residue on the substrate. CLPs do not display chitinase activity but some of them have been reported to have specific functions and carbohydrate binding property.

Propagated annotation [?]

Comments [?]

Similarity Belongs to the glycosyl hydrolase 18 family.

Cross-references [?]

case <FTTag:ACT_SITE>
PROSITE PS01095; GH18_1; 1;

Keywords [?]

end case

case <FTTag:disulf>
end case

Features [?]

From: PS51910
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       GH18 #        
ACT_SITE     120     120       Proton donor   ACT_SITE   E  
case <FTGroup:1>
BINDING     51     52       /ligand="chitin" /ligand_id="ChEBI:CHEBI:17029        
BINDING     78     81       /ligand="chitin" /ligand_id="ChEBI:CHEBI:17029        
BINDING     183     186       /ligand="chitin" /ligand_id="ChEBI:CHEBI:17029        
end case

BINDING     121     121       /ligand="chitin" /ligand_id="ChEBI:CHEBI:17029     Y   1
BINDING     302     302       /ligand="chitin" /ligand_id="ChEBI:CHEBI:17029     W   1
DISULFID     5     27           disulf   C-x*-C  

Additional information [?]

Size range 250-490 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9BWS9 (CHID1_HUMAN)
Viruses; Alphabaculovirus
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]