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annotation rule: PRU01258

General rule information [?]

Accession PRU01258
Dates 5-NOV-2019 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51910; GH18_2
Name Glycosyl hydrolases family 18 (GH18) domain
Function The GH18 family contains hydrolytic enzymes with chitinase or endo- N-acetyl-beta-D-glucosaminidase (ENGase) activity as well as chitinase like lectins (chi-lectins/proteins (CLPs). Chitinases (EC 3.2.1.14) are hydrolytic enzymes that cleave the beta-1,4-bond releasing oligomeric, dimeric (chitobiose) or monomeric (N-actetylglucosamine, GlcNAc) products. ENGases (EC 3.2.1.96) hydrolyze the beta-1,4 linkage in the chitobiose core of N- linked glycans from glycoproteins leaving one GlcNAc residue on the substrate. CLPs do not display chitinase activity but some of them have been reported to have specific functions and carbohydrate binding property.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the glycosyl hydrolase 18 family.

Cross-references [?]

case <FTTag:ACT_SITE>
PROSITE PS01095; GH18_1; 1;

Keywords [?]

end case

case <FTTag:disulf>
end case


Features [?]

From: PS51910
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       GH18 #        
ACT_SITE     120     120       Proton donor   ACT_SITE   E  
case <FTGroup:1>
REGION     51     52       Chitooligosaccharide binding        
REGION     78     81       Chitooligosaccharide binding        
REGION     183     186       Chitooligosaccharide binding        
end case

BINDING     121     121       Chitooligosaccharide     Y   1
BINDING     302     302       Chitooligosaccharide     W   1
DISULFID     5     27           disulf   C-x*-C  

Additional information [?]

Size range 250-490 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9BWS9 (CHID1_HUMAN)
Scope
Eukaryota
Bacteria
Viruses; Alphabaculovirus
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]