We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

ProRule PRU01258

View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01258

General rule information [?]

Accession	PRU01258
Dates	05-NOV-2019 (Created) 19-NOV-2022 (Last updated, Version 6)
Data class	Domain;
Predictors	PROSITE; PS51910; GH18_2
Name	Glycosyl hydrolases family 18 (GH18) domain
Function	The GH18 family contains hydrolytic enzymes with chitinase or endo- N-acetyl-beta-D-glucosaminidase (ENGase) activity as well as chitinase like lectins (chi-lectins/proteins (CLPs). Chitinases (EC 3.2.1.14) are hydrolytic enzymes that cleave the beta-1,4-bond releasing oligomeric, dimeric (chitobiose) or monomeric (N-actetylglucosamine, GlcNAc) products. ENGases (EC 3.2.1.96) hydrolyze the beta-1,4 linkage in the chitobiose core of N- linked glycans from glycoproteins leaving one GlcNAc residue on the substrate. CLPs do not display chitinase activity but some of them have been reported to have specific functions and carbohydrate binding property.
Scope(s)	Eukaryota Bacteria Viruses Alphabaculovirus
Example(s)	Q9BWS9;

Propagated annotation [?]

Comments [?]

SIMILARITY	Belongs to the glycosyl hydrolase 18 family.
case <FTTag:ACT_SITE>

Keywords [?]

Hydrolase
Glycosidase
end case
case <FTTag:disulf>
Disulfide bond
end case

Cross-references [?]

PROSITE

PS01095; GH18_1; 1;

Features [?]

From: PS51910

Key

From

Description

Tag

Condition

FTGroup

DOMAIN

from

/note="GH18 #"

ACT_SITE

120

/note="Proton donor"

ACT_SITE

case <FTGroup:1>

BINDING