PRU01258

General rule information [?]

Accession	PRU01258
Dates	5-NOV-2019 (Created) 19-NOV-2022 (Last updated, Version 5)

Data class

Domain

Predictors

PROSITE; PS51910; GH18_2

Name	Glycosyl hydrolases family 18 (GH18) domain

Function

The GH18 family contains hydrolytic enzymes with chitinase or endo- N-acetyl-beta-D-glucosaminidase (ENGase) activity as well as chitinase like lectins (chi-lectins/proteins (CLPs). Chitinases (EC 3.2.1.14) are hydrolytic enzymes that cleave the beta-1,4-bond releasing oligomeric, dimeric (chitobiose) or monomeric (N-actetylglucosamine, GlcNAc) products. ENGases (EC 3.2.1.96) hydrolyze the beta-1,4 linkage in the chitobiose core of N- linked glycans from glycoproteins leaving one GlcNAc residue on the substrate. CLPs do not display chitinase activity but some of them have been reported to have specific functions and carbohydrate binding property.

Propagated annotation [?]

Comments [?]

Similarity

Belongs to the glycosyl hydrolase 18 family.

Cross-references [?]

case <FTTag:ACT_SITE>

PROSITE

PS01095; GH18_1; 1;

Keywords [?]

Hydrolase
Glycosidase

end case

case <FTTag:disulf>

Disulfide bond

end case

Features [?]

From: PS51910

Key From To Description Tag Condition FTGroup

DOMAIN from to GH18 #

ACT_SITE 120 120 Proton donor ACT_SITE E

case <FTGroup:1>

BINDING 51 52 /ligand="chitin" /ligand_id="ChEBI:CHEBI:17029

BINDING 78 81 /ligand="chitin" /ligand_id="ChEBI:CHEBI:17029

BINDING 183 186 /ligand="chitin" /ligand_id="ChEBI:CHEBI:17029

end case

BINDING 121 121 /ligand="chitin" /ligand_id="ChEBI:CHEBI:17029 Y 1

BINDING 302 302 /ligand="chitin" /ligand_id="ChEBI:CHEBI:17029 W 1

DISULFID 5 27 disulf C-x*-C

Additional information [?]

Size range	250-490 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q9BWS9 (CHID1_HUMAN)
Scope	Eukaryota Bacteria Viruses; Alphabaculovirus
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Bacteria [32]

Eukaryota [135]

Viruses [2]

All [ 169 ]
Retrieve set of proteins with 3D structure for this domain

Bacteria	[32]
Eukaryota	[135]
Viruses	[2]
All	[ 169 ]