ProRule PRU01258

Accession	PRU01258
Dates	5-NOV-2019 (Created) 19-NOV-2022 (Last updated, Version 5)
Data class	Domain;
Predictors	PROSITE; PS51910; GH18_2
Name	Glycosyl hydrolases family 18 (GH18) domain
Function	The GH18 family contains hydrolytic enzymes with chitinase or endo- N-acetyl-beta-D-glucosaminidase (ENGase) activity as well as chitinase like lectins (chi-lectins/proteins (CLPs). Chitinases (EC 3.2.1.14) are hydrolytic enzymes that cleave the beta-1,4-bond releasing oligomeric, dimeric (chitobiose) or monomeric (N-actetylglucosamine, GlcNAc) products. ENGases (EC 3.2.1.96) hydrolyze the beta-1,4 linkage in the chitobiose core of N- linked glycans from glycoproteins leaving one GlcNAc residue on the substrate. CLPs do not display chitinase activity but some of them have been reported to have specific functions and carbohydrate binding property.
Scope(s)	Eukaryota Bacteria Viruses Alphabaculovirus
Example(s)	Q9BWS9 (CHID1_HUMAN);

From: PS51910
Key	From	To	Description	Tag	Condition	FTGroup
DOMAIN	from	to	/note="GH18 #"
ACT_SITE	120	120	/note="Proton donor"	ACT_SITE	E
case <FTGroup:1>
BINDING	51	52	/ligand="chitin" /ligand_id="ChEBI:CHEBI:17029"
BINDING	78	81	/ligand="chitin" /ligand_id="ChEBI:CHEBI:17029"
BINDING	183	186	/ligand="chitin" /ligand_id="ChEBI:CHEBI:17029"
end case
BINDING	121	121	/ligand="chitin" /ligand_id="ChEBI:CHEBI:17029"		Y	1
BINDING	302	302	/ligand="chitin" /ligand_id="ChEBI:CHEBI:17029"		W	1
DISULFID	5	27		disulf	C-x*-C