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annotation rule: PRU01258 |
Accession | PRU01258 |
Dates | 5-NOV-2019 (Created) 22-NOV-2019 (Last updated, Version 2) |
Data class | Domain |
Predictors | PROSITE; PS51910; GH18_2 |
Name | Glycosyl hydrolases family 18 (GH18) domain |
Function | The GH18 family contains hydrolytic enzymes with chitinase or endo- N-acetyl-beta-D-glucosaminidase (ENGase) activity as well as chitinase like lectins (chi-lectins/proteins (CLPs). Chitinases (EC 3.2.1.14) are hydrolytic enzymes that cleave the beta-1,4-bond releasing oligomeric, dimeric (chitobiose) or monomeric (N-actetylglucosamine, GlcNAc) products. ENGases (EC 3.2.1.96) hydrolyze the beta-1,4 linkage in the chitobiose core of N- linked glycans from glycoproteins leaving one GlcNAc residue on the substrate. CLPs do not display chitinase activity but some of them have been reported to have specific functions and carbohydrate binding property. |
Similarity | Belongs to the glycosyl hydrolase 18 family. |
PROSITE | PS01095; GH18_1; 1; |
From: PS51910 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | GH18 # | |||||||||
ACT_SITE | 120 | 120 | Proton donor | ACT_SITE | E |
REGION | 51 | 52 | Chitooligosaccharide binding | |||||||||
REGION | 78 | 81 | Chitooligosaccharide binding | |||||||||
REGION | 183 | 186 | Chitooligosaccharide binding |
BINDING | 121 | 121 | Chitooligosaccharide | Y | 1 | |||||||
BINDING | 302 | 302 | Chitooligosaccharide | W | 1 | |||||||
DISULFID | 5 | 27 | disulf | C-x*-C |
Size range | 250-490 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q9BWS9 (CHID1_HUMAN) |
Scope | Eukaryota
Bacteria
Viruses; Alphabaculovirus |
Comments | None |
Bacteria | [29] | |
Eukaryota | [135] | |
Viruses | [2] | |
All | [ 166 ] |