ProRule PRU01258

General rule information [?]

Accession PRU01258
Dates 5-NOV-2019 (Created)
19-NOV-2022 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51910; GH18_2
Name Glycosyl hydrolases family 18 (GH18) domain
Function The GH18 family contains hydrolytic enzymes with chitinase or endo- N-acetyl-beta-D-glucosaminidase (ENGase) activity as well as chitinase like lectins (chi-lectins/proteins (CLPs). Chitinases (EC are hydrolytic enzymes that cleave the beta-1,4-bond releasing oligomeric, dimeric (chitobiose) or monomeric (N-actetylglucosamine, GlcNAc) products. ENGases (EC hydrolyze the beta-1,4 linkage in the chitobiose core of N- linked glycans from glycoproteins leaving one GlcNAc residue on the substrate. CLPs do not display chitinase activity but some of them have been reported to have specific functions and carbohydrate binding property.
Scope(s) Eukaryota
Example(s) Q9BWS9 (CHID1_HUMAN);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the glycosyl hydrolase 18 family.
case <FTTag:ACT_SITE>

Keywords [?]

end case
case <FTTag:disulf>
Disulfide bond
end case

Cross-references [?]

PROSITE PS01095; GH18_1; 1;

Features [?]

From: PS51910
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="GH18 #"
ACT_SITE 120 120 /note="Proton donor" ACT_SITE E
case <FTGroup:1>
BINDING 51 52 /ligand="chitin"
BINDING 78 81 /ligand="chitin"
BINDING 183 186 /ligand="chitin"
end case
BINDING 121 121 /ligand="chitin"
Y 1
BINDING 302 302 /ligand="chitin"
W 1
DISULFID 5 27 disulf C-x*-C

Additional information [?]

Size range 250-490 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]