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annotation rule: PRU01267 |
Accession | PRU01267 |
Dates | 24-MAR-2020 (Created) 24-MAR-2020 (Last updated, Version 1) |
Data class | Domain |
Predictors | PROSITE; PS51919; X4E |
Name | Sarbecovirus X4e domain |
Function | The Sarbecovirus accessory protein X4, also called 7a or U122, is likely to be a type I membrane protein, with the amino-terminal hydrophilic domain oriented inside the lumen of the ER/Golgi or on the surface of the cell membrane or virus particle, depending on the localization of the protein. It has been suggested that X4e contains a binding site for the alpha(L) integrin subunit I-domain of LFA-1. |
Function | Non-structural protein which is dispensable for virus replication in cell culture. |
Subcellular location | Virion. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. |
Domain | The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins. |
From: PS51919 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | X4e # | |||||||||
DISULFID | 8 | 43 | disulf | C-x*-C | ||||||||
DISULFID | 20 | 52 | disulf | C-x*-C |
Size range | 60-75 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | P59635 (NS7A_SARS) |
Scope | Viruses; Sarbecovirus |
Comments | None |
Viruses | [5] |