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ProRule PRU01267


General rule information [?]

Accession PRU01267
Dates 24-MAR-2020 (Created)
27-JUL-2023 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51919; X4E
Name Sarbecovirus X4e domain
Function The Sarbecovirus accessory protein X4, also called 7a or U122, is likely to be a type I membrane protein, with the amino-terminal hydrophilic domain oriented inside the lumen of the ER/Golgi or on the surface of the cell membrane or virus particle, depending on the localization of the protein. It has been suggested that X4e contains a binding site for the alpha(L) integrin subunit I-domain of LFA-1.
Scope(s) Viruses
Sarbecovirus
Example(s) P59635 (NS7A_SARS);

Propagated annotation [?]

Comments [?]

FUNCTIONNon-structural protein which is dispensable for virus replication in cell culture.
SUBCELLULAR LOCATIONVirion. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein.
DOMAINThe di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case
G0/G1 host cell cycle checkpoint dysregulation by virus
Host Golgi apparatus
Host endoplasmic reticulum
Host membrane
Host-virus interaction
Membrane
Modulation of host cell cycle by virus
Signal
Transmembrane
Transmembrane helix
Virion

Gene Ontology [?]

GO:0016020; Cellular component:membrane
GO:0044173; Cellular component:host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0044167; Cellular component:host cell endoplasmic reticulum membrane
GO:0039646; Biological process:perturbation by virus of host G0/G1 transition checkpoint
GO:0044178; Cellular component:host cell Golgi membrane

Features [?]

From: PS51919
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="X4e #"
DISULFID 8 43 disulf C-x*-C
DISULFID 20 52 disulf C-x*-C

Additional information [?]

Size range 60-75 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]