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| annotation rule: PRU01267 |
General rule information
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| Accession | PRU01267 |
| Dates | 24-MAR-2020 (Created) 24-MAR-2020 (Last updated, Version 1) |
| Data class | Domain |
| Predictors | PROSITE; PS51919; X4E |
| Name | Sarbecovirus X4e domain |
| Function | The Sarbecovirus accessory protein X4, also called 7a or U122, is likely to be a type I membrane protein, with the amino-terminal hydrophilic domain oriented inside the lumen of the ER/Golgi or on the surface of the cell membrane or virus particle, depending on the localization of the protein. It has been suggested that X4e contains a binding site for the alpha(L) integrin subunit I-domain of LFA-1. |
Propagated annotation
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Comments
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| Function | Non-structural protein which is dispensable for virus replication in cell culture. |
| Subcellular location | Virion. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. |
| Domain | The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins. |
Gene Ontology
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GO:0016021; Cellular component: integral component of membrane.
GO:0044173; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment membrane.
GO:0044167; Cellular component: host cell endoplasmic reticulum membrane.
GO:0039646; Biological process: modulation by virus of host G0/G1 transition checkpoint.
GO:0019012; Cellular component: virion.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0044173; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment membrane.
GO:0044167; Cellular component: host cell endoplasmic reticulum membrane.
GO:0039646; Biological process: modulation by virus of host G0/G1 transition checkpoint.
GO:0019012; Cellular component: virion.
GO:0044178; Cellular component: host cell Golgi membrane.
Keywords
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case <FTTag:disulf>
end case
G0/G1 host cell cycle checkpoint dysregulation by virus
Host Golgi apparatus
Host endoplasmic reticulum
Host membrane
Host-virus interaction
Membrane
Modulation of host cell cycle by virus
Signal
Transmembrane
Transmembrane helix
Virion
Host Golgi apparatus
Host endoplasmic reticulum
Host membrane
Host-virus interaction
Membrane
Modulation of host cell cycle by virus
Signal
Transmembrane
Transmembrane helix
Virion
Features
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| From: PS51919 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | X4e # | |||||||||
| DISULFID | 8 | 43 | disulf | C-x*-C | ||||||||
| DISULFID | 20 | 52 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 60-75 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P59635 (NS7A_CVHSA) |
| Scope | Viruses; Sarbecovirus |
| Comments | None |
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UniProtKB rule member sequences
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