We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01267
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01267
General rule information
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| Accession | PRU01267 |
| Dates | 24-MAR-2020 (Created)
01-MAR-2024 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51919; X4E |
Name | Sarbecovirus X4e domain |
| Function | The Sarbecovirus accessory protein X4, also called 7a or U122, is likely to be a type I membrane protein, with the amino-terminal hydrophilic domain oriented inside the lumen of the ER/Golgi or on the surface of the cell membrane or virus particle, depending on the localization of the protein. It has been suggested that X4e contains a binding site for the alpha(L) integrin subunit I-domain of LFA-1. |
| Scope(s) |
Viruses Sarbecovirus |
| Example(s) | P59635; |
Propagated annotation
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Comments
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| FUNCTION | Non-structural protein which is dispensable for virus replication in cell culture. |
| SUBCELLULAR LOCATION | Virion. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. |
| DOMAIN | The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins. |
Keywords
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Gene Ontology
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| GO:0016020; Cellular component:membrane |
| GO:0044173; Cellular component:host cell endoplasmic reticulum-Golgi intermediate compartment membrane |
| GO:0044167; Cellular component:host cell endoplasmic reticulum membrane |
| GO:0039646; Biological process:symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint |
| GO:0044178; Cellular component:host cell Golgi membrane |
Features
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| From: PS51919 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="X4e #" | |||||||||
| DISULFID | 8 | 43 | disulf | C-x*-C | ||||||||
| DISULFID | 20 | 52 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 60-75 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [5] All [ 5 ]
- Retrieve set of proteins with 3D structure for this domain