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annotation rule: PRU01267

General rule information [?]

Accession PRU01267
Dates 24-MAR-2020 (Created)
24-MAR-2020 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51919; X4E
Name Sarbecovirus X4e domain
Function The Sarbecovirus accessory protein X4, also called 7a or U122, is likely to be a type I membrane protein, with the amino-terminal hydrophilic domain oriented inside the lumen of the ER/Golgi or on the surface of the cell membrane or virus particle, depending on the localization of the protein. It has been suggested that X4e contains a binding site for the alpha(L) integrin subunit I-domain of LFA-1.

Propagated annotation [?]


Comments [?]

Function Non-structural protein which is dispensable for virus replication in cell culture.
Subcellular location Virion. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein.
Domain The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

Gene Ontology [?]

GO:0016021; Cellular component: integral component of membrane.
GO:0044173; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment membrane.
GO:0044167; Cellular component: host cell endoplasmic reticulum membrane.
GO:0039646; Biological process: modulation by virus of host G0/G1 transition checkpoint.
GO:0019012; Cellular component: virion.
GO:0044178; Cellular component: host cell Golgi membrane.

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case

G0/G1 host cell cycle checkpoint dysregulation by virus
Host Golgi apparatus
Host endoplasmic reticulum
Host membrane
Host-virus interaction
Membrane
Modulation of host cell cycle by virus
Signal
Transmembrane
Transmembrane helix
Virion

Features [?]

From: PS51919
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       X4e #        
DISULFID     8     43           disulf   C-x*-C  
DISULFID     20     52           disulf   C-x*-C  

Additional information [?]

Size range 60-75 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P59635 (NS7A_SARS)
Scope
Viruses; Sarbecovirus
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]