ProRule PRU01267
General rule information
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Accession | PRU01267 |
Dates | 24-MAR-2020 (Created)
1-MAR-2024 (Last updated, Version 5) |
Data class | Domain; |
Predictors |
PROSITE; PS51919; X4E |
Name | Sarbecovirus X4e domain |
Function | The Sarbecovirus accessory protein X4, also called 7a or U122, is likely to be a type I membrane protein, with the amino-terminal hydrophilic domain oriented inside the lumen of the ER/Golgi or on the surface of the cell membrane or virus particle, depending on the localization of the protein. It has been suggested that X4e contains a binding site for the alpha(L) integrin subunit I-domain of LFA-1. |
Scope(s) |
Viruses Sarbecovirus |
Example(s) | P59635 (NS7A_SARS); |
Propagated annotation
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Comments
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FUNCTION | Non-structural protein which is dispensable for virus replication in cell culture. |
SUBCELLULAR LOCATION | Virion. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. |
DOMAIN | The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins. |
Keywords
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Gene Ontology
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GO:0016020; Cellular component:membrane |
GO:0044173; Cellular component:host cell endoplasmic reticulum-Golgi intermediate compartment membrane |
GO:0044167; Cellular component:host cell endoplasmic reticulum membrane |
GO:0039646; Biological process:symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint |
GO:0044178; Cellular component:host cell Golgi membrane |
Features
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From: PS51919 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="X4e #" | |||||||||
DISULFID | 8 | 43 | disulf | C-x*-C | ||||||||
DISULFID | 20 | 52 | disulf | C-x*-C |
Additional information
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Size range | 60-75 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [5] All [ 5 ]
- Retrieve set of proteins with 3D structure for this domain