We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01271
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01271
General rule information
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| Accession | PRU01271 |
| Dates | 14-APR-2020 (Created)
30-SEP-2022 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51923; COV_S2_HR1 |
Name | Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region |
| Function | The S2 subunit contains two 4-3 heptad repeats (HRs) of hydrophobic residues, HR1 and HR2, typical of coiled coils, separated by an ~170-aa-long intervening domain. The S2 subunit is expected to present rearrangement of its HRs to form a stable 6-helix bundle fusion core. |
| Scope(s) |
Viruses Orthocoronavirinae |
| Example(s) | P12650; |
Propagated annotation
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Keywords
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| Coiled coil |
| Host membrane |
| Host-virus interaction |
| Membrane |
| Viral attachment to host cell |
| Viral envelope protein |
| Virion |
| Virulence |
| Virus entry into host cell |
Gene Ontology
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| GO:0016020; Cellular component:membrane |
| GO:0044173; Cellular component:host cell endoplasmic reticulum-Golgi intermediate compartment membrane |
| GO:0055036; Cellular component:virion membrane |
| GO:0019031; Cellular component:viral envelope |
| GO:0039654; Biological process:fusion of virus membrane with host endosome membrane |
| GO:0019064; Biological process:fusion of virus membrane with host plasma membrane |
| GO:0075509; Biological process:endocytosis involved in viral entry into host cell |
| GO:0046813; Biological process:receptor-mediated virion attachment to host cell |
Features
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| From: PS51923 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | from | to | /note="Heptad repeat 1 (HR1) #" | |||||||||
Additional information
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| Size range | 100-125 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [50] All [ 50 ]
- Retrieve set of proteins with 3D structure for this domain