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| annotation rule: PRU01271 |
General rule information
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| Accession | PRU01271 |
| Dates | 14-APR-2020 (Created) 30-SEP-2022 (Last updated, Version 4) |
| Data class | Domain |
| Predictors | PROSITE; PS51923; COV_S2_HR1 |
| Name | Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region |
| Function | The S2 subunit contains two 4-3 heptad repeats (HRs) of hydrophobic residues, HR1 and HR2, typical of coiled coils, separated by an ~170-aa-long intervening domain. The S2 subunit is expected to present rearrangement of its HRs to form a stable 6-helix bundle fusion core. |
Propagated annotation
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Gene Ontology
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GO:0016020; Cellular component: membrane.
GO:0044173; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment membrane.
GO:0055036; Cellular component: virion membrane.
GO:0019031; Cellular component: viral envelope.
GO:0039654; Biological process: fusion of virus membrane with host endosome membrane.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
GO:0075509; Biological process: endocytosis involved in viral entry into host cell.
GO:0046813; Biological process: receptor-mediated virion attachment to host cell.
GO:0044173; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment membrane.
GO:0055036; Cellular component: virion membrane.
GO:0019031; Cellular component: viral envelope.
GO:0039654; Biological process: fusion of virus membrane with host endosome membrane.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
GO:0075509; Biological process: endocytosis involved in viral entry into host cell.
GO:0046813; Biological process: receptor-mediated virion attachment to host cell.
Keywords
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Coiled coil
Host membrane
Host-virus interaction
Membrane
Viral attachment to host cell
Viral envelope protein
Virion
Virulence
Virus entry into host cell
Host membrane
Host-virus interaction
Membrane
Viral attachment to host cell
Viral envelope protein
Virion
Virulence
Virus entry into host cell
Features
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| From: PS51923 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | from | to | Heptad repeat 1 (HR1) # | |||||||||
Additional information
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| Size range | 100-125 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P12650 (SPIKE_IBVK) |
| Scope | Viruses; Orthocoronavirinae |
| Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Viruses [50]
- Retrieve set of proteins with 3D structure for this domain