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Entry: PS51923

General information about the entry

Entry name [info] COV_S2_HR1
Accession [info] PS51923
Entry type [info] MATRIX
Date [info] 17-JUN-2020 CREATED;
17-JUN-2020 DATA UPDATE;
12-AUG-2020 INFO UPDATE.
PROSITE Doc. [info] PDOC51923
Associated ProRule [info] PRU01271

Name and characterization of the entry

Description [info] Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=106;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=101;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.0207658; R2=0.0076496; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=978; N_SCORE=10.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=455; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-41; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='I';  M= 20,-73,-80,-78,-55, 11,-82, 86,-75,-40,-42,-71,-73,-72,-78,-63,-57, 36,-76,-61;
/M: SY='P';  M= 20,-76,-64,-57,-79,-63,-68,-69,-61,-76,-67,-62,104,-63,-71, 11, 50,-66,-81,-76;
/M: SY='W';  M=-74,-77,-78,-78, 99,-74,-70,-58,-71,-52,-59, 42,-82,-76,-73,-70,-68,-65,126,-26;
/M: SY='A';  M= 76,-65,-62,-57,-70,-54,-62,-61,-59, 13,-56, 31,-69, 38,-63, 12,-52,-55,-77,-67;
/M: SY='T';  M=-56,-67, 38,-54,-67,-70,-63,  9,-57,-58, 45,-48,-63, 29,-63,-44, 94,-51,-85,-63;
/M: SY='Q';  M= 48,-74,-59,-44,-82,-61,-54,-73,-43,-71,-60,-53,-67,101, 37, 13,-56,-67,-74,-64;
/M: SY='I';  M=-60,-72,-85,-80,-50,-86,-79, 78,-76,  7, 54,-77,-76,-73,-78,-71,-56, 60,-78,-57;
/M: SY='Q';  M=-54,-74,-53,-45, 19,-60,-51,-72,-48,-70,-62, 44,-68,101,-50, 57,-51,-72,-73,-58;
/M: SY='A';  M= 86,-65,-69,-64, 23,  6,-65,-64,-65,-64,-60,-63,-69,-62,-68,-45,-55,-55,-65, 32;
/M: SY='R';  M=-67,-83,-63,-51,-76,-77,-52,-83,-24,-75,-64,-56,-75,-40,117,-61,-66,-76,-76,-62;
/M: SY='L';  M=-65,-71,-85,-78,-44,-86,-71, 49,-77, 72, 46,-80,-80,-71,-76,-75,-61, 14,-73,-54;
/M: SY='N';  M=-62,-67,-35,-57,-77,-50,-43,-76,-48,-84,-70,125,-73,-50,-56,-44,-47,-78,-96,-72;
/M: SY='H';  M= 48,-71,-62,-62,-58, 32, 84,-72,-62,-68,-60,-54,-70,-56,-63, 30,-57,-66,-66, 62;
/M: SY='L';  M=-63,-69,-84,-77,-43,-86,-73, 18,-77, 79,-31,-82,-82,-72,-76,-75,-60, 39,-74,-55;
/M: SY='G';  M= 30,-73,-65,-73,-82, 95,-71,-85,-68,-82,-72,-52,-68,-66,-75,-48,-65,-76,-74,-77;
/M: SY='I';  M=-62,-72,-85,-80,-47,-87,-80, 72,-78, 47,-35,-79,-78,-74,-78,-73,-57, 53,-76,-57;
/M: SY='T';  M=-53,-63,-59,-58,-67,-69,-64,-57,-56,-59, 42,-48,-60, 32,-62,-39,107,-52,-85,-63;
/M: SY='Q';  M=-57,-77,-58,-42,-78,-69,-54,-59,-46,-63,-55,-52,-66,115,-47,-48, 44, 23,-77,-62;
/M: SY='N';  M=-55,-73, 47, 21,-80, 45,-56,-80,-54,-80,-71, 54,-66, 30,-61, 30, 14,-75,-84,-71;
/M: SY='V';  M= 27,-67,-75,-66,-56,-73,-70,-35, 28, 32, 53,-70,-74,-63,-61,-62,-55, 62,-78,-60;
/M: SY='L';  M=-66,-71,-85,-78,-43,-86,-69, 44,-77, 78, 53,-81,-81,-70,-75,-76,-62,-35,-72,-53;
/M: SY='M';  M=-57,-72,-71,-58,-61,-73,-59, 12,-58,-43,100,-63,-71, 77,-59, 10,-55, 42,-77,-57;
/M: SY='E';  M=-59,-77, 21, 90,-82,-68,-53,-82, 32,-78,-72, 24,-59,-38,-48, 17,-55,-76,-82,-71;
/M: SY='N';  M=-64,-71, 68,-48,-80,-54,-45,-79,-50,-84,-73,111,-71,-51,-58,-47,-49,-80,-98,-72;
/M: SY='Q';  M=-59,-80,-61,-44,-73,-72, 48, 17,-49,-58,-51,-55,-70,111,-49,-54,-60, 34,-77,-58;
/M: SY='K';  M=-59,-76,-49, 34,-81,-65,-54,-78, 79,-77,-66, 25,-63, 63,-35, 19,-55,-75,-76,-66;
/M: SY='K';  M=-61,-75,-67,-55,-62,-76,-64, 38, 74,  1, 41,-60,-69, 30,-43,-62,-57, 25,-74,-60;
/M: SY='I';  M=-66,-75,-86,-82,-46,-89,-79, 90,-79, 51,-33,-79,-77,-74,-80,-75,-60,-25,-73,-55;
/M: SY='A';  M= 83,-63, 18,-57,-74,-52,-67,-61,-62,-66,-62,-57,-67,-58,-67, 31,-50,  8,-79,-70;
/M: SY='N';  M= 20,-73,-43, 43,-81,-59,-50,-76, 14,-76,-66, 82,-66, 70,-49,-48,-54,-73,-82,-69;
/M: SY='G';  M= 48,-69,-61,-58,-79, 57,-64,-76, 11,-76,-67,-51,-66, 31,-60, 47,-53,-68,-76,-71;
/M: SY='F';  M=-73,-71,-87,-83,118,-83,-69,-45,-78,-40,-50,-77,-85,-88,-76,-73,-65, 13,-43,-21;
/M: SY='N';  M=-62,-67,-35,-57,-77,-50,-43,-76,-48,-84,-70,125,-73,-50,-56,-44,-47,-78,-96,-72;
/M: SY='K';  M=-59,-73,-50,-48,-78, 12,-55,-76, 77,-78,-66, 67,-66, 31,-39,-49, 24,-73,-79,-68;
/M: SY='A';  M= 75,-65,-74,-67,-58,-61,-70, 18,-69, 46,-45,-70,-72,-64,-71,-53,-56,-43,-74,-63;
/M: SY='I';  M= 10,-71,-80,-76,-51,-80,-79, 77,-74, 25,-39,-73,-74,-72,-77,-64, 15, 37,-77,-59;
/M: SY='D';  M=-58,-73, 50,-54,-70, 43,-61,-60,  8, 12,-59, 25,-69, 29,-61,-53, 24,  7,-82,-67;
/M: SY='H';  M=  3,-72, 38,-54, 20,-60, 89,-73,-58,-69,-63, 28,-70,-53,-60, 56,-52,-70,-75, 31;
/M: SY='M';  M=-57,-69,-84,-76,-52,-81,-70, 42,-72,-33,106,-75,-75,-68,-72,-69,-55, 69,-79,-56;
/M: SY='Q';  M=  4,-70,-56,-47,-79,-57,-55,-72,-50,-72,-63,-48,-64, 92,-52, 74, 19,-67,-78,-64;
/M: SY='K';  M=-59,-74, 20, 52,-74,-67,-55,-71, 52, -4,-63, 32,-64, 29,-46, 13, 16,-68,-80,-67;
/M: SY='G';  M=  5,-75,-68,-72,-72, 83,-68,-68,-69,  1, 51,-57, 28,-66,-74,-54,-64,-68,-74,-71;
/M: SY='F';  M= 34,-69,-83,-77,107,-74,-68,-50,-75,  3,-50,-74,-81,-80,-74,-65,-63,-52,-48,-28;
/M: SY='K';  M=-57,-72,-51, 39,-75,-68,-59,-73, 63,-73,-65,-49,-62,-44, 38, 20, 60,-66,-79,-66;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='T';  M= 61,-62,-63,-61,-70,-58,-69,-56,-61,-63,-59,-54,-64,-60,-67, 32, 72, 15,-82,-67;
/M: SY='T';  M=-54,-65,-67,-67,-60,-74,-71, 31,-63,-49, 46,-56,-65,-66,-69,-47, 92, 37,-84,-62;
/M: SY='A';  M= 65,-64,-59,-61, 40,-53,-61,-66,-60,-67,-63, 52,-69,-57,-65, 52,-48,-59,-72,-58;
/M: SY='S';  M= 21,-70, 28, 13,-74, 13,-57,-70,-55, -7,-64, 44,-67, 33,-60, 53,-50,-67,-81,-68;
/M: SY='A';  M= 79,-63,-64,-60,-76, 14,-66,-69,-61,-71,-65,-55,-66,-56,-66, 57,-48,-58,-77,-70;
/M: SY='I';  M=-68,-72,-86,-80, 53,-87,-73, 64,-79, 63,-34,-80,-81,-75,-78,-76,-62,-33,-64,-45;
/M: SY='T';  M=-50,-66,-49, 20,-74,-58,-57,-70,-52,-72,-66, 45,-63, 28,-59, 67, 68,-63,-85,-67;
/M: SY='Q';  M=  2,-77,-56, 17,-78,-69,-56,-66, 62,-69,-60,-53,-66, 82, 28,-54,-58, 10,-75,-64;
/M: SY='I';  M=-64,-76,-78,-81,-51,-85,-80,100,-75,-35,-38, 25,-74,-73,-79,-69,-57, 16,-76,-58;
/M: SY='Q';  M=-60,-84,-51, 34,-87,-69,-51,-77, 33,-74,-61,-52, 28,112,-41,-52,-61,-77,-74,-65;
/M: SY='M';  M= 10,-70, 44,-57,-73, 45,-60,-68,-60,-67, 63, 27,-67,-57,-66, 37, 19,-65,-82,-67;
/M: SY='V';  M= 50,-64,-75,-69,-58,-69,-76,-34,-69, 16,-46,-70,-73,-69,-72,-55, 18, 72,-81,-63;
/M: SY='V';  M=-54,-66,-83,-77,-52,-84,-83,-20,-75, 18,-40,-79,-80,-76,-76,-67,-52, 97,-85,-60;
/M: SY='N';  M=-63,-69,-39,-60,-72,-54,-47, 27,-51,-71,-63,118,-73,-53,-59,-47,-48,-63,-92,-69;
/M: SY='Q';  M= 47,-70,-57,-52,-80, 25,-58,-74,-53,-74,-64, 28,-67, 76,-57, 48,-51,-67,-77,-68;
/M: SY='N';  M=-63,-73,-48,-51,-72,-61,-48,-67,-44, 12,-57, 92,-73, 74, 37,-51,-55,-70,-82,-65;
/M: SY='A';  M= 57,-66,-69,-68,-70, 49,-73,-50,-67,-61,-59,-60,-70,-65,-71, 13,-53, 51,-79,-69;
/M: SY='Q';  M= 29,-73,-63, 16,-56,-70,-58,-54, 30, 47,-47,-63,-71, 58,-53,-58,-60,-55,-67, 31;
/M: SY='Q';  M= 44,-71,-63,-51, 40,-62,-59,-61,-54,-62,-57,-57,-69, 90,-55, 30,-54,  3,-69,-54;
/M: SY='L';  M=-64,-69,-85,-77, 42,-84,-69,-31,-76, 69, 53,-80,-82,-72,-74,-74,-61, 37,-68,-47;
/I:         I=-38; MD=-97;
/M: SY='Q';  M=  2,-76,-57, 21,-81,-66,-60,-73,-57,-72, 49, 43,-72, 57,-62, 37, 17,-70,-87,-71; D=-38;
/I:         I=-38; MI=-97; MD=-97; IM=-97; DM=-97;
/M: SY='Q';  M=  7,-82,-65, 11,-78,-76,-64,-65, 37,  2,-60,-63,-74, 82,-52,-61,-65,  6,-81,-69; D=-38;
/I:         I=-38; DM=-97;
/M: SY='L';  M=-72,-75,-91,-83,-48,-93,-76,-37,-84, 81,-36,-90,-90,-78,-82,-83,-68,  7,-79,-61; D=-38;
/I:         I=-38; DM=-97;
/M: SY='V';  M= 31,-67,-78,-72,-53,-75,-75, 32,-72, 45,-40,-72,-75,-70,-74,-60, 19, 51,-78,-60;
/M: SY='N';  M=-55,-72, 27,-50,-76,  7,-55,-63, 20,-71,-64, 62,-69, 58,-53, 38,-51, 22,-83,-67;
/M: SY='Q';  M= 11,-77,-52, 50,-66, 34,-53,-75,-51,-71,-63,-55,-66, 76,-55,  9,-59,-71,-64, 52;
/M: SY='L';  M=-65,-70,-69, 31, 42,-82,-66,-41,-68, 72,-38,-73,-76,-64,-70,-67, 23,-46,-68,-49;
/M: SY='Q';  M=-53,-72, 39,-49,-76,  9,-53,-71,-53,-70, 51, 51,-67, 62,-57, 60,-49,-70,-83,-65;
/M: SY='N';  M=-64,-76, 50, 22,-64,-67,-51,-67, 37, 12,-59, 53,-69, 50,-49,-56,-57,-69,-73, 33;
/M: SY='N';  M=-62,-67,-43,-60, 40,-56,-49,-68,-53,-71,-65,109,-72,-56,-60,-45, 44,-68,-82,-58;
/M: SY='F';  M=-68,-72,-78,-73,108,-76,-64,-55,-62,-48,-55,-67,-81,-71, 35, 27,-61,-58,-48,-27;
/M: SY='G';  M=-55,-77,-68,-72, 40, 84,-69, 27,-68,-64,-62,-56,-71, 31,-73,-55,-66,-62,-67,-59;
/M: SY='W';  M= 85,-66,-74,-64,-63,-56,-73,-60,-66, 13,-56,-68,-70,-62,-69,-49,-57,-53, 95,-59;
/M: SY='I';  M=-61, 70,-81,-79,-53,-83,-78, 84,-74,-38, 64,-71,-74,-72,-78,-66, 17, 12,-79,-59;
/M: SY='S';  M=-47,-68,-57,-55,-61,-56,-54,-70,-55,-71,-64,-48,-66, 50,-58, 89, 20,-65,-68, 53;
/M: SY='S';  M=  7,-66,-54,-59,-61,-52,-52,-70,-57,-73,-66, 55,-68,-51,-61, 86,-42,-66,-70, 52;
/M: SY='N';  M=-53,-68,-53,-58,-69,-58,-57, 28, 30,-65,-60, 73,-69,-52,-55, 65,-45,  4,-83,-66;
/M: SY='F';  M=-64,-72,-86,-81, 71,-86,-77, 65,-78, 19,-40,-78,-80,-79,-78,-72,-59, 46,-63,-42;
/M: SY='I';  M= 28,-73,-54, 47,-68,-67,-62, 55, 13,-58,-55, 27,-66, 28,-57, 11,-54,-48,-77,-65;
/M: SY='E';  M=-61,-78, 45, 74,-73,-74,-57, 16,-50, -5,-60,-53,-63, 51,-57,-55, 22,-60,-81,-66;
/M: SY='I';  M=-65,-76,-74,-79,-51,-82,-75, 97,-73,  5,-38, 43,-75,-70,-77,-68,-57,-25,-76,-58;
/M: SY='Y';  M=-66,-75,-57, 53, 27,-76,-52,-52,-60, 44,-47, 30,-74,-55,-63,-64,-61,-57,-55, 77;
/M: SY='K';  M=-60,-75,-47, 40,-78,-65,-53,-79, 73,-78,-68, 57,-65,-41, 39, 14,-54,-75,-79,-67;
/M: SY='R';  M= 20,-77,-62,-52,-76,-69,-55,-79, 20,-74,-64,-55,-72,-43,101,  8,-60,-71,-76,-64;
/M: SY='L';  M=-64,-70,-81,-76,-44, 21,-69,-37,-77, 85,-32,-77,-82,-70,-75,-72,-64,-44,-71,-56;
/M: SY='D';  M=  3,-75, 80, 41,-74,-66,-55,-70, 20, 11,-64, 32,-67,-50,-56,-55,-57,-69,-86,-68;
/M: SY='M';  M= 38,-73,-61, 12,-70,-66,-57,-61, 42, -1, 63,-58,-67, 63, 18,-54,-59,-60,-74,-62;
/M: SY='V';  M=-58,-69,-79,-75,-50,-79,-74, 49,-74, 51,-38,-73,-77,-69,-75, 27,-54, 52,-77,-58;
/M: SY='E';  M=-58,-78,-38, 86,-83,-67,-50,-80,-43,-76,-68, 44,-61, 73,-49,  9,-56,-76,-80,-69;
/M: SY='A';  M= 88,-65,-67,-58,-62,-53,-61,-65,-60,-65,-59,-62,-68, 29,-63,-44,-54,-55,-64, 52;
/M: SY='D';  M=  1,-76, 83, 44,-77,-65,-56, 26,-54,-70,-67, 52,-66,-51,-62,-54,-56,-62,-90,-69;
/M: SY='A';  M= 69,-69,-66,-57,-73, 24,-64, 10,-59,-61, 42,-59,-68, 65,-62,-48,-57,-54,-74,-66;
/M: SY='Q';  M=-58,-83,-53, 19,-86, 23, 49,-79,-44,-73,-60,-50,-66,115,-46,-50,-63,-79,-75,-61;
/M: SY='M';  M=-60,-71,-80,-71,-52,-80,-64, 16,-61, 19,104,-72,-75,-62, 35,-69,-58, 50,-77,-55;
/M: SY='D';  M=-65,-77,105,-39,-77,-68,-58, 27,-58,-69,-69,-40,-67,-58,-66,-54, 35,-62,-96,-67;
/M: SY='R';  M= 19,-80,-64,-53,-77,-71,-56,-79,-31,-75,-64,-59, 46,-45,102,-58,-63,-72,-76,-66;
/I:         I=-45; MD=-115;
/M: SY='L';  M=-72,-75,-91,-83,-48,-93,-77,-37,-84, 80,-36,-90,-90,-78,-82,-82,-68, 16,-79,-61; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='I';  M=-65,-77,-86,-83,-48,-90,-83,102,-79, 20,-34,-77,-75,-75,-82,-74,-59,-21,-73,-56;
/M: SY='N';  M=-57,-65,-42,-58,-73,-55,-50,-70,-51,-76,-67,103,-67,-53,-59, 16, 67,-67,-92,-69;
/M: SY='G';  M=-51,-77,-67,-77,-76, 97,-73, 26,-71,-73,-67,-53,-69,-68,-78,-52,-67,-67,-74,-74;
/M: SY='R';  M=-67,-82,-63,-53,-62,-76,-50,-78, 25,-71,-62,-57,-75,-42,105,-61,-65,-74,-64, 52;
/M: SY='M';  M=-64,-69,-84,-75,-44,-81,-62,-33,-73, 70,109,-77,-78,-65,-70,-74,-62,-41,-72,-52;
/I:         E1=0; IE=-380; DE=-380;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2020_04 which contains 563'082 sequence entries.


Total number of hits 50 in 50 different sequences
Number of true positive hits 50 in 50 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotic viruses
Maximum number of repetitions [info] 1
Feature key [info] REGION
Feature description [info] Heptad repeat 1 (HR1)
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
50 sequences

SPIKE_BC133 (Q0Q4F2    ), SPIKE_BC279 (Q0Q475    ), SPIKE_BC512 (Q0Q466    ), 
SPIKE_BCHK3 (Q3LZX1    ), SPIKE_BCHK4 (A3EX94    ), SPIKE_BCHK5 (A3EXD0    ), 
SPIKE_BCHK9 (A3EXG6    ), SPIKE_BCRP3 (Q3I5J5    ), SPIKE_CVBEN (Q91A26    ), 
SPIKE_CVBF  (P25190    ), SPIKE_CVBL9 (P25191    ), SPIKE_CVBLS (Q9QAR5    ), 
SPIKE_CVBLU (Q8V436    ), SPIKE_CVBLY (P25192    ), SPIKE_CVBM  (P15777    ), 
SPIKE_CVBOK (Q9QAQ8    ), SPIKE_CVBQ  (P25193    ), SPIKE_CVBV  (P25194    ), 
SPIKE_CVCAI (P36300    ), SPIKE_CVCAK (Q65984    ), SPIKE_CVCBG (Q7T6T3    ), 
SPIKE_CVH22 (P15423    ), SPIKE_CVHN1 (Q5MQD0    ), SPIKE_CVHN2 (Q14EB0    ), 
SPIKE_CVHN5 (Q0ZME7    ), SPIKE_CVHNL (Q6Q1S2    ), SPIKE_CVHOC (P36334    ), 
SPIKE_CVHSA (P59594    ), SPIKE_CVM4  (P22432    ), SPIKE_CVMA5 (P11224    ), 
SPIKE_CVMJC (Q02385    ), SPIKE_CVMJH (P11225    ), SPIKE_CVP67 (Q8BB25    ), 
SPIKE_CVPFS (P18450    ), SPIKE_CVPIA (Q8JSP8    ), SPIKE_CVPMI (P33470    ), 
SPIKE_CVPPU (P07946    ), SPIKE_CVPR8 (P27655    ), SPIKE_CVPRM (P24413    ), 
SPIKE_CVPRT (Q01977    ), SPIKE_CVRSD (Q9IKD1    ), SPIKE_FIPV  (P10033    ), 
SPIKE_IBV6  (P05135    ), SPIKE_IBVB  (P11223    ), SPIKE_IBVD2 (P12722    ), 
SPIKE_IBVK  (P12650    ), SPIKE_IBVM  (P12651    ), SPIKE_MERS1 (K9N5Q8    ), 
SPIKE_PEDV7 (Q91AV1    ), SPIKE_SARS2 (P0DTC2    )
» more

PDB
[Detailed view]
57 PDB

1WDF; 1WDG; 1WNC; 1WYY; 1ZV8; 1ZVA; 1ZVB; 2BEQ; 2BEZ; 2IEQ; 3JCL; 4MOD; 5I08; 5SZS; 5W9H; 5W9I; 5W9J; 5W9K; 5W9L; 5W9M; 5W9N; 5W9O; 5W9P; 5WRG; 5X58; 5X59; 5X5B; 5X5C; 5X5F; 5XLR; 5YL9; 5ZHY; 5ZUV; 5ZVK; 5ZVM; 6ACC; 6ACD; 6ACG; 6ACJ; 6ACK; 6B3O; 6CRV; 6CRW; 6CRX; 6CRZ; 6CS0; 6CS1; 6CS2; 6LXT; 6NB6; 6NB7; 6U7H; 6U7K; 6VSB; 6VSJ; 6VXX; 6VYB
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View entry in raw text format (no links)
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