ProRule PRU01297

Accession	PRU01297
Dates	17-DEC-2020 (Created) 19-NOV-2022 (Last updated, Version 5)
Data class	Domain;
Predictors	PROSITE; PS51952; COV_EXON_MTASE_COACT
Name	Coronavirus (CoV) ExoN/MTase coactivator domain
Function	Nsp10, a critical cofactor for activation of multiple replicative enzyme, is a small protein of ca. 140 amino acid residues that exists exclusively in viruses and not in prokaryotes or eukaryotes. Nsp10 is known to interact with both Nsp14 and Nsp16, acting as a scaffolding protein and stimulating their respective 3'-5' exoribonuclease (ExoN) and 2'-O-methyltransferase (2'-O-MTase) activities.
Scope(s)	Viruses Orthocoronavirinae
Example(s)	P0C6Y1 (R1AB_IBVB);

From: PS51952
Key	From	To	Description	Tag	Condition	FTGroup
DOMAIN	from	to	/note="ExoN/MTase coactivator #"
BINDING	74	74	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		C	1
BINDING	77	77	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		C	1
BINDING	83	83	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		H	1
BINDING	90	90	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		C	1
BINDING	116	116	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		C	2
BINDING	119	119	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		C	2
BINDING	127	127	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		C	2
BINDING	129	129	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		C	2