PRU01297

General rule information [?]

Accession	PRU01297
Dates	17-DEC-2020 (Created) 19-NOV-2022 (Last updated, Version 5)

Data class

Domain

Predictors

PROSITE; PS51952; COV_EXON_MTASE_COACT

Name	Coronavirus (CoV) ExoN/MTase coactivator domain

Function

Nsp10, a critical cofactor for activation of multiple replicative enzyme, is a small protein of ca. 140 amino acid residues that exists exclusively in viruses and not in prokaryotes or eukaryotes. Nsp10 is known to interact with both Nsp14 and Nsp16, acting as a scaffolding protein and stimulating their respective 3'-5' exoribonuclease (ExoN) and 2'-O-methyltransferase (2'-O-MTase) activities.

Propagated annotation [?]

Comments [?]

Similarity

Belongs to the coronaviruses polyprotein 1ab family.

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>

GO:0008270; Molecular function: zinc ion binding.
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

Zinc
Metal-binding
Zinc-finger

end case

Features [?]

From: PS51952

Key From To Description Tag Condition FTGroup

DOMAIN from to ExoN/MTase coactivator #

BINDING 74 74 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 C 1

BINDING 77 77 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 C 1

BINDING 83 83 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 H 1

BINDING 90 90 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 C 1

BINDING 116 116 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 C 2

BINDING 119 119 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 C 2

BINDING 127 127 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 C 2

BINDING 129 129 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 C 2

Additional information [?]

Size range	135-145 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	P0C6Y1 (R1AB_IBVB)
Scope	Viruses; Orthocoronavirinae
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Viruses [59]
Retrieve set of proteins with 3D structure for this domain