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annotation rule: PRU01297

General rule information [?]

Accession PRU01297
Dates 17-DEC-2020 (Created)
14-MAY-2022 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS51952; COV_EXON_MTASE_COACT
Name Coronavirus (CoV) ExoN/MTase coactivator domain
Function Nsp10, a critical cofactor for activation of multiple replicative enzyme, is a small protein of ca. 140 amino acid residues that exists exclusively in viruses and not in prokaryotes or eukaryotes. Nsp10 is known to interact with both Nsp14 and Nsp16, acting as a scaffolding protein and stimulating their respective 3'-5' exoribonuclease (ExoN) and 2'-O-methyltransferase (2'-O-MTase) activities.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the coronaviruses polyprotein 1ab family.

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>
GO:0008270; Molecular function: zinc ion binding.
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

end case


Features [?]

From: PS51952
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       ExoN/MTase coactivator #        
BINDING     74     74       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     C   1
BINDING     77     77       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     C   1
BINDING     83     83       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     H   1
BINDING     90     90       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     C   1
BINDING     116     116       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     C   2
BINDING     119     119       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     C   2
BINDING     127     127       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     C   2
BINDING     129     129       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     C   2

Additional information [?]

Size range 135-145 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C6Y1 (R1AB_IBVB)
Scope
Viruses; Orthocoronavirinae
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]