PRU01298

General rule information [?]

Accession	PRU01298
Dates	6-JAN-2021 (Created) 19-NOV-2022 (Last updated, Version 4)

Data class

Domain

Predictors

PROSITE; PS51953; NIV_EXON

Name	Nidovirus 3'-5' exoribonuclease (ExoN) domain

Function

The nidovirus 3'-5' exoribonuclease (ExoN) domain may enhance the fidelity of RNA synthesis by correcting nucleotide incorporation errors made by the RNA-dependent RNA polymerase.

Propagated annotation [?]

Gene Ontology [?]

case <FTGroup:1>

GO:0004527; Molecular function: exonuclease activity.

end case

case <FTGroup:2> or <FTGroup:3>

GO:0008270; Molecular function: zinc ion binding.
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

Zinc
Metal-binding
Zinc-finger

end case

case <FTGroup:1>

Exonuclease
Nuclease

end case

Features [?]

From: PS51953

Key From To Description Tag Condition FTGroup

DOMAIN from to ExoN #

ACT_SITE 19 19 D 1

ACT_SITE 21 21 E 1

ACT_SITE 120 120 [ED] 1

ACT_SITE 198 198 H 1

ACT_SITE 203 203 D 1

BINDING 136 136 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 C 2

BINDING 139 139 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 C 2

BINDING 155 155 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 C 2

BINDING 158 158 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 H 2

BINDING 186 186 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 H 3

BINDING 190 190 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 C 3

BINDING 194 194 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 H 3

BINDING 209 209 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 C 3

Additional information [?]

Size range	230-265 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	P0C6Y1 (R1AB_IBVB)
Scope	Viruses; Nidovirales
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Viruses [33]
Retrieve set of proteins with 3D structure for this domain