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annotation rule: PRU01298

General rule information [?]

Accession PRU01298
Dates 6-JAN-2021 (Created)
14-MAY-2022 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51953; NIV_EXON
Name Nidovirus 3'-5' exoribonuclease (ExoN) domain
Function The nidovirus 3'-5' exoribonuclease (ExoN) domain may enhance the fidelity of RNA synthesis by correcting nucleotide incorporation errors made by the RNA-dependent RNA polymerase.

Propagated annotation [?]


Gene Ontology [?]

case <FTGroup:1>
GO:0004527; Molecular function: exonuclease activity.
end case

case <FTGroup:2> or <FTGroup:3>
GO:0008270; Molecular function: zinc ion binding.
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

Zinc
Metal-binding
Zinc-finger
end case

case <FTGroup:1>
Exonuclease
Nuclease
end case


Features [?]

From: PS51953
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       ExoN #        
ACT_SITE     19     19             D   1
ACT_SITE     21     21             E   1
ACT_SITE     120     120             [ED]   1
ACT_SITE     198     198             H   1
ACT_SITE     203     203             D   1
BINDING     136     136       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     C   2
BINDING     139     139       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     C   2
BINDING     155     155       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     C   2
BINDING     158     158       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     H   2
BINDING     186     186       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     H   3
BINDING     190     190       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     C   3
BINDING     194     194       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     H   3
BINDING     209     209       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     C   3

Additional information [?]

Size range 230-265 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C6Y1 (R1AB_IBVB)
Scope
Viruses; Nidovirales
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]