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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01298


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01298
General rule information [?]

Accession PRU01298
Dates 06-JAN-2021 (Created)
19-NOV-2022 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51953; NIV_EXON
Name Nidovirus 3'-5' exoribonuclease (ExoN) domain
Function The nidovirus 3'-5' exoribonuclease (ExoN) domain may enhance the fidelity of RNA synthesis by correcting nucleotide incorporation errors made by the RNA-dependent RNA polymerase.
Scope(s) Viruses
Nidovirales
Example(s) P0C6Y1;

Propagated annotation [?]

Keywords [?]

Zinc
Metal-binding
Zinc-finger
end case
case <FTGroup:1>
Exonuclease
Nuclease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0004527; Molecular function:exonuclease activity
end case

Features [?]

From: PS51953
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ExoN #"
ACT_SITE 19 19 D 1
ACT_SITE 21 21 E 1
ACT_SITE 120 120 [ED] 1
ACT_SITE 198 198 H 1
ACT_SITE 203 203 D 1
BINDING 136 136 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 2
BINDING 139 139 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 2
BINDING 155 155 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 2
BINDING 158 158 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 H 2
BINDING 186 186 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 H 3
BINDING 190 190 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 C 3
BINDING 194 194 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 H 3
BINDING 209 209 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 C 3

Additional information [?]

Size range 230-265 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]