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ProRule PRU01298


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PURL: https://purl.expasy.org/prosite/rule/PRU01298
General rule information [?]

Accession PRU01298
Dates 06-JAN-2021 (Created)
19-NOV-2022 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51953; NIV_EXON
Name Nidovirus 3'-5' exoribonuclease (ExoN) domain
Function The nidovirus 3'-5' exoribonuclease (ExoN) domain may enhance the fidelity of RNA synthesis by correcting nucleotide incorporation errors made by the RNA-dependent RNA polymerase.
Scope(s) Viruses
Nidovirales
Example(s) P0C6Y1;

Propagated annotation [?]

Keywords [?]

Zinc
Metal-binding
Zinc-finger
end case
case <FTGroup:1>
Exonuclease
Nuclease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0004527; Molecular function:exonuclease activity
end case

Features [?]

From: PS51953
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ExoN #"
ACT_SITE 19 19 D 1
ACT_SITE 21 21 E 1
ACT_SITE 120 120 [ED] 1
ACT_SITE 198 198 H 1
ACT_SITE 203 203 D 1
BINDING 136 136 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 2
BINDING 139 139 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 2
BINDING 155 155 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 2
BINDING 158 158 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 H 2
BINDING 186 186 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 H 3
BINDING 190 190 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 C 3
BINDING 194 194 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 H 3
BINDING 209 209 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 C 3

Additional information [?]

Size range 230-265 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]