ProRule PRU01298
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01298 |
| Accession | PRU01298 |
| Dates | 6-JAN-2021 (Created)
19-NOV-2022 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51953; NIV_EXON |
Name | Nidovirus 3'-5' exoribonuclease (ExoN) domain |
| Function | The nidovirus 3'-5' exoribonuclease (ExoN) domain may enhance the fidelity of RNA synthesis by correcting nucleotide incorporation errors made by the RNA-dependent RNA polymerase. |
| Scope(s) |
Viruses Nidovirales |
| Example(s) | P0C6Y1 (R1AB_IBVB); |
Propagated annotation
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Keywords
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| Zinc | |
| Metal-binding | |
| Zinc-finger | |
| end case | |
| case <FTGroup:1> | |
| Exonuclease | |
| Nuclease | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0004527; Molecular function:exonuclease activity | |
| end case | |
Features
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| From: PS51953 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="ExoN #" | |||||||||
| ACT_SITE | 19 | 19 | D | 1 | ||||||||
| ACT_SITE | 21 | 21 | E | 1 | ||||||||
| ACT_SITE | 120 | 120 | [ED] | 1 | ||||||||
| ACT_SITE | 198 | 198 | H | 1 | ||||||||
| ACT_SITE | 203 | 203 | D | 1 | ||||||||
| BINDING | 136 | 136 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
C | 2 | |||||||
| BINDING | 139 | 139 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
C | 2 | |||||||
| BINDING | 155 | 155 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
C | 2 | |||||||
| BINDING | 158 | 158 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
H | 2 | |||||||
| BINDING | 186 | 186 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" |
H | 3 | |||||||
| BINDING | 190 | 190 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" |
C | 3 | |||||||
| BINDING | 194 | 194 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" |
H | 3 | |||||||
| BINDING | 209 | 209 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" |
C | 3 | |||||||
Additional information
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| Size range | 230-265 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [34] All [ 34 ]
- Retrieve set of proteins with 3D structure for this domain