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| annotation rule: PRU01303 |
General rule information
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| Accession | PRU01303 |
| Dates | 27-JAN-2021 (Created) 27-JAN-2021 (Last updated, Version 2) |
| Data class | Domain |
| Predictors | PROSITE; PS51958; NENDOU |
| Name | Nidoviral uridylate-specific endoribonuclease (NendoU) domain |
| Function | Among the Nsps found in Nidovirales, nonstructural protein 15 (nsp15) from coronaviruses and Nsp11 from arteriviruses contain in their C- terminal region a conserved endoribonuclease domain called nidoviral uridylate-specific endoribonuclease (NendoU) with cleavage specificity for single- and double-stranded RNA 5' of uridine nucleotides to produce a 2'-3'- cyclic phosphate end product. |
Propagated annotation
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Gene Ontology
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case <FTGroup:1>
GO:0004519; Molecular function: endonuclease activity.
Keywords
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end case
Features
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| From: PS51958 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | NendoU # | |||||||||
| ACT_SITE | 31 | 31 | H | 1 | ||||||||
| ACT_SITE | 46 | 46 | H | 1 | ||||||||
| ACT_SITE | 86 | 86 | K | 1 | ||||||||
Additional information
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| Size range | 120-150 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P0C6X9 (R1AB_CVMA5) |
| Scope | Viruses; Nidovirales |
| Comments | None |
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UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Viruses [44]
- Retrieve set of proteins with 3D structure for this domain