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annotation rule: PRU01303

General rule information [?]

Accession PRU01303
Dates 27-JAN-2021 (Created)
27-JAN-2021 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51958; NENDOU
Name Nidoviral uridylate-specific endoribonuclease (NendoU) domain
Function Among the Nsps found in Nidovirales, nonstructural protein 15 (nsp15) from coronaviruses and Nsp11 from arteriviruses contain in their C- terminal region a conserved endoribonuclease domain called nidoviral uridylate-specific endoribonuclease (NendoU) with cleavage specificity for single- and double-stranded RNA 5' of uridine nucleotides to produce a 2'-3'- cyclic phosphate end product.

Propagated annotation [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0004519; Molecular function: endonuclease activity.

Keywords [?]

end case

Features [?]

From: PS51958
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       NendoU #        
ACT_SITE     31     31             H   1
ACT_SITE     46     46             H   1
ACT_SITE     86     86             K   1

Additional information [?]

Size range 120-150 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C6X9 (R1AB_CVMA5)
Viruses; Nidovirales
Comments None


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UniProtKB rule member sequences [?]