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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01303


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01303
General rule information [?]

Accession PRU01303
Dates 27-JAN-2021 (Created)
27-JAN-2021 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51958; NENDOU
Name Nidoviral uridylate-specific endoribonuclease (NendoU) domain
Function Among the Nsps found in Nidovirales, nonstructural protein 15 (nsp15) from coronaviruses and Nsp11 from arteriviruses contain in their C- terminal region a conserved endoribonuclease domain called nidoviral uridylate-specific endoribonuclease (NendoU) with cleavage specificity for single- and double-stranded RNA 5' of uridine nucleotides to produce a 2'-3'- cyclic phosphate end product.
Scope(s) Viruses
Nidovirales
Example(s) P0C6X9;

Propagated annotation [?]

Keywords [?]

Hydrolase
Endonuclease
Nuclease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0004519; Molecular function:endonuclease activity

Features [?]

From: PS51958
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="NendoU #"
ACT_SITE 31 31 H 1
ACT_SITE 46 46 H 1
ACT_SITE 86 86 K 1

Additional information [?]

Size range 120-150 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]