ProRule PRU01303

General rule information [?]

Accession PRU01303
Dates 27-JAN-2021 (Created)
27-JAN-2021 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51958; NENDOU
Name Nidoviral uridylate-specific endoribonuclease (NendoU) domain
Function Among the Nsps found in Nidovirales, nonstructural protein 15 (nsp15) from coronaviruses and Nsp11 from arteriviruses contain in their C- terminal region a conserved endoribonuclease domain called nidoviral uridylate-specific endoribonuclease (NendoU) with cleavage specificity for single- and double-stranded RNA 5' of uridine nucleotides to produce a 2'-3'- cyclic phosphate end product.
Scope(s) Viruses
Example(s) P0C6X9 (R1AB_CVMA5);

Propagated annotation [?]

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0004519; Molecular function:endonuclease activity

Features [?]

From: PS51958
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="NendoU #"
ACT_SITE 31 31 H 1
ACT_SITE 46 46 H 1
ACT_SITE 86 86 K 1

Additional information [?]

Size range 120-150 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]