ProRule PRU01303
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01303 |
| Accession | PRU01303 |
| Dates | 27-JAN-2021 (Created)
27-JAN-2021 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51958; NENDOU |
Name | Nidoviral uridylate-specific endoribonuclease (NendoU) domain |
| Function | Among the Nsps found in Nidovirales, nonstructural protein 15 (nsp15) from coronaviruses and Nsp11 from arteriviruses contain in their C- terminal region a conserved endoribonuclease domain called nidoviral uridylate-specific endoribonuclease (NendoU) with cleavage specificity for single- and double-stranded RNA 5' of uridine nucleotides to produce a 2'-3'- cyclic phosphate end product. |
| Scope(s) |
Viruses Nidovirales |
| Example(s) | P0C6X9 (R1AB_CVMA5); |
Propagated annotation
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Keywords
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| Hydrolase | |
| Endonuclease | |
| Nuclease | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0004519; Molecular function:endonuclease activity | |
Features
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| From: PS51958 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="NendoU #" | |||||||||
| ACT_SITE | 31 | 31 | H | 1 | ||||||||
| ACT_SITE | 46 | 46 | H | 1 | ||||||||
| ACT_SITE | 86 | 86 | K | 1 | ||||||||
Additional information
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| Size range | 120-150 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [44] All [ 44 ]
- Retrieve set of proteins with 3D structure for this domain