We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01307
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01307
General rule information
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| Accession | PRU01307 |
| Dates | 02-MAR-2021 (Created)
02-MAR-2021 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51962; COV_NSP1 |
Name | Coronavirus (CoV) Nsp1 globular domain |
| Function | Nsp1 is a characteristic feature of AlphaCoVs and BetaCoVs, which exhibits both functional conservation and mechanistic diversity in inhibiting host gene expression and antiviral responses. Although the sequence homologies among CoV Nsp1 proteins are low, the core structures share a relatively conserved domain. |
| Scope(s) |
Viruses Orthocoronavirinae |
| Example(s) | P0C6U5; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the coronaviruses polyprotein 1ab family. |
Keywords
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Features
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| From: PS51962 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="CoV Nsp1 globular #" | |||||||||
Additional information
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| Size range | 100-150 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [54] All [ 54 ]
- Retrieve set of proteins with 3D structure for this domain