ProRule PRU01307
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01307 |
| Accession | PRU01307 |
| Dates | 2-MAR-2021 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51962; COV_NSP1 |
Name | Coronavirus (CoV) Nsp1 globular domain |
| Function | Nsp1 is a characteristic feature of AlphaCoVs and BetaCoVs, which exhibits both functional conservation and mechanistic diversity in inhibiting host gene expression and antiviral responses. Although the sequence homologies among CoV Nsp1 proteins are low, the core structures share a relatively conserved domain. |
| Scope(s) |
Viruses Orthocoronavirinae |
| Example(s) | P0C6U5 (R1A_CVHN5); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the coronaviruses polyprotein 1ab family. |
Keywords
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Features
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| From: PS51962 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="CoV Nsp1 globular #" | |||||||||
Additional information
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| Size range | 100-150 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [54] All [ 54 ]
- Retrieve set of proteins with 3D structure for this domain