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annotation rule: PRU01307

General rule information [?]

Accession PRU01307
Dates 2-MAR-2021 (Created)
2-MAR-2021 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51962; COV_NSP1
Name Coronavirus (CoV) Nsp1 globular domain
Function Nsp1 is a characteristic feature of AlphaCoVs and BetaCoVs, which exhibits both functional conservation and mechanistic diversity in inhibiting host gene expression and antiviral responses. Although the sequence homologies among CoV Nsp1 proteins are low, the core structures share a relatively conserved domain.

Propagated annotation [?]

Comments [?]

Similarity Belongs to the coronaviruses polyprotein 1ab family.

Keywords [?]

Features [?]

From: PS51962
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       CoV Nsp1 globular #        

Additional information [?]

Size range 100-150 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C6U5 (R1A_CVHN5)
Viruses; Orthocoronavirinae
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]