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| annotation rule: PRU01307 |
General rule information
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| Accession | PRU01307 |
| Dates | 2-MAR-2021 (Created) 2-MAR-2021 (Last updated, Version 1) |
| Data class | Domain |
| Predictors | PROSITE; PS51962; COV_NSP1 |
| Name | Coronavirus (CoV) Nsp1 globular domain |
| Function | Nsp1 is a characteristic feature of AlphaCoVs and BetaCoVs, which exhibits both functional conservation and mechanistic diversity in inhibiting host gene expression and antiviral responses. Although the sequence homologies among CoV Nsp1 proteins are low, the core structures share a relatively conserved domain. |
Propagated annotation
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Comments
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| Similarity | Belongs to the coronaviruses polyprotein 1ab family. |
Keywords
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Inhibition of host innate immune response by virus
Viral immunoevasion
Eukaryotic host translation shutoff by virus
Host mRNA suppression by virus
Inhibition of host interferon signaling pathway by virus
Viral immunoevasion
Eukaryotic host translation shutoff by virus
Host mRNA suppression by virus
Inhibition of host interferon signaling pathway by virus
Features
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| From: PS51962 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | CoV Nsp1 globular # | |||||||||
Additional information
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| Size range | 100-150 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P0C6U5 (R1A_CVHN5) |
| Scope | Viruses; Orthocoronavirinae |
| Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Viruses [54]
- Retrieve set of proteins with 3D structure for this domain