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annotation rule: PRU01334

General rule information [?]

Accession PRU01334
Dates 9-DEC-2021 (Created)
9-DEC-2021 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51990; COV_NSP2_M
Name Coronavirus (CoV) Nsp2 middle domain
Function Nsp2 has been implicated in processes ranging from translation repression to endosomal transport, ribosome biogenesis, and actin filament binding. Nsp2 in SARS-CoV-2 and other coronaviruses have been observed to localize to endosomes and replication-transcription complexes (RTC). Nsp2 may be involved in binding nucleic acids and regulating intracellular signaling pathways. It contains an N-terminal, a middle and a C-terminal domain.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the coronaviruses polyprotein 1ab family.

Features [?]

From: PS51990
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       CoV Nsp2 middle #        

Additional information [?]

Size range 180-400 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C6W5 (R1AB_BCHK9)
Scope
Viruses; Orthocoronavirinae
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]