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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01334


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01334
General rule information [?]

Accession PRU01334
Dates 09-DEC-2021 (Created)
09-DEC-2021 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51990; COV_NSP2_M
Name Coronavirus (CoV) Nsp2 middle domain
Function Nsp2 has been implicated in processes ranging from translation repression to endosomal transport, ribosome biogenesis, and actin filament binding. Nsp2 in SARS-CoV-2 and other coronaviruses have been observed to localize to endosomes and replication-transcription complexes (RTC). Nsp2 may be involved in binding nucleic acids and regulating intracellular signaling pathways. It contains an N-terminal, a middle and a C-terminal domain.
Scope(s) Viruses
Orthocoronavirinae
Example(s) P0C6W5;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the coronaviruses polyprotein 1ab family.

Features [?]

From: PS51990
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CoV Nsp2 middle #"

Additional information [?]

Size range 180-400 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]