ProRule PRU01334
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01334 |
| Accession | PRU01334 |
| Dates | 9-DEC-2021 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51990; COV_NSP2_M |
Name | Coronavirus (CoV) Nsp2 middle domain |
| Function | Nsp2 has been implicated in processes ranging from translation repression to endosomal transport, ribosome biogenesis, and actin filament binding. Nsp2 in SARS-CoV-2 and other coronaviruses have been observed to localize to endosomes and replication-transcription complexes (RTC). Nsp2 may be involved in binding nucleic acids and regulating intracellular signaling pathways. It contains an N-terminal, a middle and a C-terminal domain. |
| Scope(s) |
Viruses Orthocoronavirinae |
| Example(s) | P0C6W5 (R1AB_BCHK9); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the coronaviruses polyprotein 1ab family. |
Features
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| From: PS51990 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="CoV Nsp2 middle #" | |||||||||
Additional information
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| Size range | 180-400 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [53] All [ 53 ]
- Retrieve set of proteins with 3D structure for this domain