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annotation rule: PRU01334 |
Accession | PRU01334 |
Dates | 9-DEC-2021 (Created) 9-DEC-2021 (Last updated, Version 1) |
Data class | Domain |
Predictors | PROSITE; PS51990; COV_NSP2_M |
Name | Coronavirus (CoV) Nsp2 middle domain |
Function | Nsp2 has been implicated in processes ranging from translation repression to endosomal transport, ribosome biogenesis, and actin filament binding. Nsp2 in SARS-CoV-2 and other coronaviruses have been observed to localize to endosomes and replication-transcription complexes (RTC). Nsp2 may be involved in binding nucleic acids and regulating intracellular signaling pathways. It contains an N-terminal, a middle and a C-terminal domain. |
Similarity | Belongs to the coronaviruses polyprotein 1ab family. |
From: PS51990 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | CoV Nsp2 middle # |
Size range | 180-400 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | P0C6W5 (R1AB_BCHK9) |
Scope | Viruses; Orthocoronavirinae |
Comments | None |
Viruses | [53] |