ProRule PRU01334

General rule information [?]

Accession PRU01334
Dates 9-DEC-2021 (Created)
-- (Last updated, Version 1)
Data class Domain;
Predictors PROSITE; PS51990; COV_NSP2_M
Name Coronavirus (CoV) Nsp2 middle domain
Function Nsp2 has been implicated in processes ranging from translation repression to endosomal transport, ribosome biogenesis, and actin filament binding. Nsp2 in SARS-CoV-2 and other coronaviruses have been observed to localize to endosomes and replication-transcription complexes (RTC). Nsp2 may be involved in binding nucleic acids and regulating intracellular signaling pathways. It contains an N-terminal, a middle and a C-terminal domain.
Scope(s) Viruses
Example(s) P0C6W5 (R1AB_BCHK9);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the coronaviruses polyprotein 1ab family.

Features [?]

From: PS51990
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CoV Nsp2 middle #"

Additional information [?]

Size range 180-400 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]