We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01344
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01344
General rule information
[?]
| Accession | PRU01344 |
| Dates | 17-JUN-2022 (Created)
19-NOV-2022 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52000; COV_NSP12_IF |
Name | Coronavirus Nsp12 Interface domain |
| Function | The coronavirus Nsp12 subunit contains an N-terminal NiRAN domain, an interface domain, composed of three helices and five beta strands, and a C-terminal polymerase domain, which resembles a right hand, comprising the fingers, palm and thumb subdomains. |
| Scope(s) |
Viruses Orthocoronavirinae |
| Example(s) | P0C6X6; |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Protein name | AltName: Full=ORF1ab polyprotein; |
Comments
[?]
| SIMILARITY | Belongs to the coronaviruses polyprotein 1ab family. |
Keywords
[?]
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
[?]
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
Features
[?]
| From: PS52000 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Nsp12 Interface #" | |||||||||
| BINDING | 30 | 30 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[HC] | 1 | |||||||
| BINDING | 36 | 36 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 41 | 41 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 45 | 45 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
Additional information
[?]
| Size range | 90-110 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]
- UniProtKB/Swiss-Prot sets
Viruses [30] All [ 30 ]
- Retrieve set of proteins with 3D structure for this domain