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ProRule PRU01344


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01344
Accession PRU01344
Dates 17-JUN-2022 (Created)
19-NOV-2022 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52000; COV_NSP12_IF
Name Coronavirus Nsp12 Interface domain
Function The coronavirus Nsp12 subunit contains an N-terminal NiRAN domain, an interface domain, composed of three helices and five beta strands, and a C-terminal polymerase domain, which resembles a right hand, comprising the fingers, palm and thumb subdomains.
Scope(s) Viruses
Orthocoronavirinae
Example(s) P0C6X6 (R1AB_CVHOC);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name AltName: Full=ORF1ab polyprotein;

Comments [?]

SIMILARITYBelongs to the coronaviruses polyprotein 1ab family.

Keywords [?]

Metal-binding
Zinc
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS52000
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Nsp12 Interface #"
BINDING 30 30 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [HC] 1
BINDING 36 36 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 41 41 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 45 45 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 90-110 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]