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annotation rule: PRU01344

General rule information [?]

Accession PRU01344
Dates 17-JUN-2022 (Created)
19-NOV-2022 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS52000; COV_NSP12_IF
Name Coronavirus Nsp12 Interface domain
Function The coronavirus Nsp12 subunit contains an N-terminal NiRAN domain, an interface domain, composed of three helices and five beta strands, and a C-terminal polymerase domain, which resembles a right hand, comprising the fingers, palm and thumb subdomains.

Propagated annotation [?]

Description [?]

AltName: Full=ORF1ab polyprotein;

Comments [?]

Similarity Belongs to the coronaviruses polyprotein 1ab family.

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

end case

Features [?]

From: PS52000
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Nsp12 Interface #        
BINDING     30     30       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [HC]   1
BINDING     36     36       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     41     41       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     45     45       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1

Additional information [?]

Size range 90-110 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C6X6 (R1AB_CVHOC)
Viruses; Orthocoronavirinae
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]