ProRule PRU01344
General rule information
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Accession | PRU01344 |
Dates | 17-JUN-2022 (Created)
19-NOV-2022 (Last updated, Version 2) |
Data class | Domain; |
Predictors |
PROSITE; PS52000; COV_NSP12_IF |
Name | Coronavirus Nsp12 Interface domain |
Function | The coronavirus Nsp12 subunit contains an N-terminal NiRAN domain, an interface domain, composed of three helices and five beta strands, and a C-terminal polymerase domain, which resembles a right hand, comprising the fingers, palm and thumb subdomains. |
Scope(s) |
Viruses Orthocoronavirinae |
Example(s) | P0C6X6 (R1AB_CVHOC); |
Propagated annotation
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Identifier, protein and gene names
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Protein name | AltName: Full=ORF1ab polyprotein; |
Comments
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SIMILARITY | Belongs to the coronaviruses polyprotein 1ab family. |
Keywords
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Metal-binding | |
Zinc | |
end case |
Gene Ontology
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case <FTGroup:1> | |
GO:0008270; Molecular function:zinc ion binding |
Features
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From: PS52000 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="Nsp12 Interface #" | |||||||||
BINDING | 30 | 30 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[HC] | 1 | |||||||
BINDING | 36 | 36 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
BINDING | 41 | 41 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
BINDING | 45 | 45 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 |
Additional information
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Size range | 90-110 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [30] All [ 30 ]
- Retrieve set of proteins with 3D structure for this domain