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annotation rule: PRU01344 |
Accession | PRU01344 |
Dates | 17-JUN-2022 (Created) 19-NOV-2022 (Last updated, Version 2) |
Data class | Domain |
Predictors | PROSITE; PS52000; COV_NSP12_IF |
Name | Coronavirus Nsp12 Interface domain |
Function | The coronavirus Nsp12 subunit contains an N-terminal NiRAN domain, an interface domain, composed of three helices and five beta strands, and a C-terminal polymerase domain, which resembles a right hand, comprising the fingers, palm and thumb subdomains. |
AltName: Full=ORF1ab polyprotein; |
Similarity | Belongs to the coronaviruses polyprotein 1ab family. |
From: PS52000 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | Nsp12 Interface # | |||||||||
BINDING | 30 | 30 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 | [HC] | 1 | |||||||
BINDING | 36 | 36 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 | [CH] | 1 | |||||||
BINDING | 41 | 41 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 | [CH] | 1 | |||||||
BINDING | 45 | 45 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 | [CH] | 1 |
Size range | 90-110 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | P0C6X6 (R1AB_CVHOC) |
Scope | Viruses; Orthocoronavirinae |
Comments | None |
Viruses | [30] |