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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01351


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PURL: https://purl.expasy.org/prosite/rule/PRU01351
General rule information [?]

Accession PRU01351
Dates 21-SEP-2022 (Created)
19-NOV-2022 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS52007; PADR1
Name PADR1 zinc-binding domain
Function The PADR1 zinc-binding domain is involved in protein-protein interactions that orchestrate PARP-1 activation and are critical to the DNA- dependent stimulation of PARP-1. It relays the DNA binding signal from the first two zinc fingers to the catalytic C terminus by helping to establish the active form of the enzyme.
Scope(s) Eukaryota
Example(s) Q9N4H4;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus. Nucleus, nucleolus. Chromosome. Note=Localizes to sites of DNA damage.
SIMILARITYBelongs to the ARTD/PARP family.

Keywords [?]

Metal-binding
Zinc
end case
ADP-ribosylation
Nucleus

Gene Ontology [?]

GO:0005730; Cellular component:nucleolus
GO:0070212; Biological process:protein poly-ADP-ribosylation
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS52007
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PADR1 zinc-binding #"
REGION 66 108 /note="Zinc ribbon #"
BINDING 71 71 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 74 74 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 87 87 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 97 97 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 130-155 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]