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General rule information [?]

Accession PRU01351
Dates 21-SEP-2022 (Created)
19-NOV-2022 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS52007; PADR1
Name PADR1 zinc-binding domain
Function The PADR1 zinc-binding domain is involved in protein-protein interactions that orchestrate PARP-1 activation and are critical to the DNA- dependent stimulation of PARP-1. It relays the DNA binding signal from the first two zinc fingers to the catalytic C terminus by helping to establish the active form of the enzyme.

Propagated annotation [?]

Comments [?]

Subcellular location Nucleus. Nucleus, nucleolus. Chromosome. Note=Localizes to sites of DNA damage.
Similarity Belongs to the ARTD/PARP family.

Gene Ontology [?]

GO:0005730; Cellular component: nucleolus.
GO:0070212; Biological process: protein poly-ADP-ribosylation.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

end case

Features [?]

From: PS52007
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       PADR1 zinc-binding #        
REGION     66     108       Zinc ribbon #        
BINDING     71     71       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     74     74       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     87     87       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     97     97       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1

Additional information [?]

Size range 130-155 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9N4H4 (PARP1_CAEEL)
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]