General rule information
[?]
Accession |
PRU01351 |
Dates |
21-SEP-2022 (Created) 21-SEP-2022 (Last updated, Version 1) |
Name |
PADR1 zinc-binding domain |
Function |
The PADR1 zinc-binding domain is involved in protein-protein interactions that orchestrate PARP-1 activation and are critical to the DNA- dependent stimulation of PARP-1. It relays the DNA binding signal from the first two zinc fingers to the catalytic C terminus by helping to establish the active form of the enzyme. |
Propagated annotation
[?]
Subcellular location |
Nucleus. Nucleus, nucleolus. Chromosome. Note=Localizes to sites of DNA damage. |
Similarity |
Belongs to the ARTD/PARP family. |
GO:0005730; Cellular component: nucleolus.
GO:0070212; Biological process: protein poly-ADP-ribosylation.
case <FTGroup:1>
end case
From: PS52007 |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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DOMAIN
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from
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to
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PADR1 zinc-binding #
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REGION
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66
|
|
108
|
|
Zinc ribbon #
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BINDING
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71
|
|
71
|
|
/ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1
|
|
|
|
[CH]
|
|
1
|
BINDING
|
|
74
|
|
74
|
|
/ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1
|
|
|
|
[CH]
|
|
1
|
BINDING
|
|
87
|
|
87
|
|
/ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1
|
|
|
|
[CH]
|
|
1
|
BINDING
|
|
97
|
|
97
|
|
/ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1
|
|
|
|
[CH]
|
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1
|
Additional information
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Size range |
130-155 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q9N4H4 (PARP1_CAEEL) |
Scope |
Eukaryota |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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