PRU01351

General rule information [?]

Accession	PRU01351
Dates	21-SEP-2022 (Created) 19-NOV-2022 (Last updated, Version 2)

Data class

Domain

Predictors

PROSITE; PS52007; PADR1

Name	PADR1 zinc-binding domain

Function

The PADR1 zinc-binding domain is involved in protein-protein interactions that orchestrate PARP-1 activation and are critical to the DNA- dependent stimulation of PARP-1. It relays the DNA binding signal from the first two zinc fingers to the catalytic C terminus by helping to establish the active form of the enzyme.

Propagated annotation [?]

Comments [?]

Subcellular location	Nucleus. Nucleus, nucleolus. Chromosome. Note=Localizes to sites of DNA damage.
Similarity	Belongs to the ARTD/PARP family.

Gene Ontology [?]

GO:0005730; Cellular component: nucleolus.
GO:0070212; Biological process: protein poly-ADP-ribosylation.

case <FTGroup:1>

GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

Metal-binding
Zinc

end case

ADP-ribosylation
Nucleus

Features [?]

From: PS52007

Key From To Description Tag Condition FTGroup

DOMAIN from to PADR1 zinc-binding #

REGION 66 108 Zinc ribbon #

BINDING 71 71 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 [CH] 1

BINDING 74 74 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 [CH] 1

BINDING 87 87 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 [CH] 1

BINDING 97 97 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 [CH] 1

Additional information [?]

Size range	130-155 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q9N4H4 (PARP1_CAEEL)
Scope	Eukaryota
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Eukaryota [18]
Retrieve set of proteins with 3D structure for this domain