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| annotation rule: PRU01351 |
General rule information
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| Accession | PRU01351 |
| Dates | 21-SEP-2022 (Created) 21-SEP-2022 (Last updated, Version 1) |
| Data class | Domain |
| Predictors | PROSITE; PS52007; PADR1 |
| Name | PADR1 zinc-binding domain |
| Function | The PADR1 zinc-binding domain is involved in protein-protein interactions that orchestrate PARP-1 activation and are critical to the DNA- dependent stimulation of PARP-1. It relays the DNA binding signal from the first two zinc fingers to the catalytic C terminus by helping to establish the active form of the enzyme. |
Propagated annotation
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Comments
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| Subcellular location | Nucleus. Nucleus, nucleolus. Chromosome. Note=Localizes to sites of DNA damage. |
| Similarity | Belongs to the ARTD/PARP family. |
Gene Ontology
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GO:0005730; Cellular component: nucleolus.
GO:0070212; Biological process: protein poly-ADP-ribosylation.
GO:0070212; Biological process: protein poly-ADP-ribosylation.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
Keywords
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end case
Features
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| From: PS52007 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | PADR1 zinc-binding # | |||||||||
| REGION | 66 | 108 | Zinc ribbon # | |||||||||
| BINDING | 71 | 71 | /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1 | [CH] | 1 | |||||||
| BINDING | 74 | 74 | /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1 | [CH] | 1 | |||||||
| BINDING | 87 | 87 | /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1 | [CH] | 1 | |||||||
| BINDING | 97 | 97 | /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1 | [CH] | 1 | |||||||
Additional information
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| Size range | 130-155 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q9N4H4 (PARP1_CAEEL) |
| Scope | Eukaryota |
| Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Eukaryota [18]
- Retrieve set of proteins with 3D structure for this domain