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ProRule PRU01351


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01351
Accession PRU01351
Dates 21-SEP-2022 (Created)
19-NOV-2022 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52007; PADR1
Name PADR1 zinc-binding domain
Function The PADR1 zinc-binding domain is involved in protein-protein interactions that orchestrate PARP-1 activation and are critical to the DNA- dependent stimulation of PARP-1. It relays the DNA binding signal from the first two zinc fingers to the catalytic C terminus by helping to establish the active form of the enzyme.
Scope(s) Eukaryota
Example(s) Q9N4H4 (PARP1_CAEEL);

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus. Nucleus, nucleolus. Chromosome. Note=Localizes to sites of DNA damage.
SIMILARITYBelongs to the ARTD/PARP family.

Keywords [?]

Metal-binding
Zinc
end case
ADP-ribosylation
Nucleus

Gene Ontology [?]

GO:0005730; Cellular component:nucleolus
GO:0070212; Biological process:protein poly-ADP-ribosylation
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS52007
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PADR1 zinc-binding #"
REGION 66 108 /note="Zinc ribbon #"
BINDING 71 71 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 74 74 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 87 87 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 97 97 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 130-155 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]