We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01356
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01356
General rule information
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| Accession | PRU01356 |
| Dates | 10-NOV-2022 (Created)
10-NOV-2022 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52012; CFEM |
Name | CFEM) domain |
| Function | Common in Fungal Extracellular Membrane (CFEM) proteins, characterized by a distinctive pattern of eight cysteine residues of conserved interspacing, are widespread among fungi. The CFEM domain adopts a helical-basket fold that consists of six alpha-helices, and is uniquely stabilized by four disulfide bonds formed by its eight signature cysteines. |
| Scope(s) |
Eukaryota Ascomycota |
| Example(s) | Q4WMA6; |
Propagated annotation
[?]
Keywords
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| Heme | |
| Iron | |
| Metal-binding | |
| end case | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| GO:0005576; Cellular component:extracellular region | |
| case <FTTag:heme> | |
| GO:0046872; Molecular function:metal ion binding | |
Features
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| From: PS52012 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="CFEM #" | |||||||||
| DISULFID | 29 | 69 | disulf | C-x*-C | ||||||||
| DISULFID | 33 | 64 | disulf | C-x*-C | ||||||||
| DISULFID | 43 | 50 | disulf | C-x*-C | ||||||||
| DISULFID | 52 | 85 | disulf | C-x*-C | ||||||||
| BINDING | 47 | 47 | /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue" |
heme | D | |||||||
Additional information
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| Size range | 107-119 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-4 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [22] All [ 22 ]
- Retrieve set of proteins with 3D structure for this domain