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annotation rule: PRU01356

General rule information [?]

Accession PRU01356
Dates 10-NOV-2022 (Created)
10-NOV-2022 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS52012; CFEM
Name CFEM) domain
Function Common in Fungal Extracellular Membrane (CFEM) proteins, characterized by a distinctive pattern of eight cysteine residues of conserved interspacing, are widespread among fungi. The CFEM domain adopts a helical-basket fold that consists of six alpha-helices, and is uniquely stabilized by four disulfide bonds formed by its eight signature cysteines.

Propagated annotation [?]


Gene Ontology [?]

GO:0005576; Cellular component: extracellular region.
case <FTTag:heme>
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

Heme
Iron
Metal-binding
end case

case <FTTag:disulf>
Disulfide bond
end case


Features [?]

From: PS52012
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       CFEM #        
DISULFID     29     69           disulf   C-x*-C  
DISULFID     33     64           disulf   C-x*-C  
DISULFID     43     50           disulf   C-x*-C  
DISULFID     52     85           disulf   C-x*-C  
BINDING     47     47       /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue   heme   D  

Additional information [?]

Size range 107-119 amino acids
Related rules None
Repeats 1-4
Topology Undefined
Example Q4WMA6 (CFMB_ASPFU)
Scope
Eukaryota; Ascomycota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]