ProRule PRU01356
General rule information
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| Accession | PRU01356 |
| Dates | 10-NOV-2022 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52012; CFEM |
Name | CFEM) domain |
| Function | Common in Fungal Extracellular Membrane (CFEM) proteins, characterized by a distinctive pattern of eight cysteine residues of conserved interspacing, are widespread among fungi. The CFEM domain adopts a helical-basket fold that consists of six alpha-helices, and is uniquely stabilized by four disulfide bonds formed by its eight signature cysteines. |
| Scope(s) |
Eukaryota Ascomycota |
| Example(s) | Q4WMA6 (CFMB_ASPFU); |
Propagated annotation
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Keywords
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| Heme | |
| Iron | |
| Metal-binding | |
| end case | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| GO:0005576; Cellular component:extracellular region | |
| case <FTTag:heme> | |
| GO:0046872; Molecular function:metal ion binding | |
Features
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| From: PS52012 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="CFEM #" | |||||||||
| DISULFID | 29 | 69 | disulf | C-x*-C | ||||||||
| DISULFID | 33 | 64 | disulf | C-x*-C | ||||||||
| DISULFID | 43 | 50 | disulf | C-x*-C | ||||||||
| DISULFID | 52 | 85 | disulf | C-x*-C | ||||||||
| BINDING | 47 | 47 | /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue" |
heme | D | |||||||
Additional information
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| Size range | 107-119 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-4 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [22] All [ 22 ]
- Retrieve set of proteins with 3D structure for this domain