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ProRule PRU01356


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01356
Accession PRU01356
Dates 10-NOV-2022 (Created)
-- (Last updated, Version 1)
Data class Domain;
Predictors PROSITE; PS52012; CFEM
Name CFEM) domain
Function Common in Fungal Extracellular Membrane (CFEM) proteins, characterized by a distinctive pattern of eight cysteine residues of conserved interspacing, are widespread among fungi. The CFEM domain adopts a helical-basket fold that consists of six alpha-helices, and is uniquely stabilized by four disulfide bonds formed by its eight signature cysteines.
Scope(s) Eukaryota
Ascomycota
Example(s) Q4WMA6 (CFMB_ASPFU);

Propagated annotation [?]

Keywords [?]

Heme
Iron
Metal-binding
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

GO:0005576; Cellular component:extracellular region
case <FTTag:heme>
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS52012
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CFEM #"
DISULFID 29 69 disulf C-x*-C
DISULFID 33 64 disulf C-x*-C
DISULFID 43 50 disulf C-x*-C
DISULFID 52 85 disulf C-x*-C
BINDING 47 47 /ligand="heme"
/ligand_id="ChEBI:CHEBI:30413"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 heme D

Additional information [?]

Size range 107-119 amino acids
Related rules None
Fusion None
Repeats 1-4
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]