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ProRule PRU01368


General rule information [?]

Accession PRU01368
Dates 9-JUN-2023 (Created)
1-MAR-2024 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52024; GL_AHV
Name Alphaherpesvirus glycoprotein L (gL) domain
Function Two glycoprotein complexes are conserved throughout the three herpesvirus subfamilies: the trimeric glycoprotein B (gB) that functions as a membrane fusogen and the heterodimeric glycoprotein H/glycoprotein L (gH/gL), the role of which is less clearly defined. The intrinsic structural plasticity of gH/gL enables it to function as a signal integration machine that can accept diverse regulatory inputs and convert them into a "trigger" signal that activates the fusogenic ability of gB.
Scope(s) Viruses
Alphaherpesvirinae
Example(s) P52510 (GL_GAHVG);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + AltName: Full=Envelope glycoprotein L;
                 Short=gL;

Comments [?]

FUNCTIONThe heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.
SUBUNITInteracts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.
SUBCELLULAR LOCATIONVirion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.
SIMILARITYBelongs to the herpesviridae glycoprotein L (gL) family. Alphaherpesvirinae gL subfamily.

Keywords [?]

Fusion of virus membrane with host cell membrane
Fusion of virus membrane with host membrane
Glycoprotein
Host Golgi apparatus
Host cell membrane
Host membrane
Membrane
Viral envelope protein
Viral penetration into host cytoplasm
Virion
Virus entry into host cell
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

GO:0044177; Cellular component:host cell Golgi apparatus
GO:0055036; Cellular component:virion membrane
GO:0016020; Cellular component:membrane
GO:0046718; Biological process:symbiont entry into host cell
GO:0020002; Cellular component:host cell plasma membrane
GO:0019064; Biological process:fusion of virus membrane with host plasma membrane
GO:0019031; Cellular component:viral envelope

Features [?]

From: PS52024
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="gL alphaherpesvirus-type #"
DISULFID 22 53 disulf C-x*-C
DISULFID 126 138 disulf C-x*-C

Additional information [?]

Size range 107-179 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]