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General rule information [?]

Accession PRU01368
Dates 9-JUN-2023 (Created)
9-JUN-2023 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS52024; GL_AHV
Name Alphaherpesvirus glycoprotein L (gL) domain
Function Two glycoprotein complexes are conserved throughout the three herpesvirus subfamilies: the trimeric glycoprotein B (gB) that functions as a membrane fusogen and the heterodimeric glycoprotein H/glycoprotein L (gH/gL), the role of which is less clearly defined. The intrinsic structural plasticity of gH/gL enables it to function as a signal integration machine that can accept diverse regulatory inputs and convert them into a "trigger" signal that activates the fusogenic ability of gB.

Propagated annotation [?]

Description [?]

+ AltName: Full=Envelope glycoprotein L; Short=gL;

Comments [?]

Function The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.
Subunit Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.
Subcellular location Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.
Similarity Belongs to the herpesviridae glycoprotein L (gL) family. Alphaherpesvirinae gL subfamily.

Gene Ontology [?]

GO:0044177; Cellular component: host cell Golgi apparatus.
GO:0055036; Cellular component: virion membrane.
GO:0016020; Cellular component: membrane.
GO:0046718; Biological process: viral entry into host cell.
GO:0020002; Cellular component: host cell plasma membrane.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
GO:0019031; Cellular component: viral envelope.

Keywords [?]

case <FTTag:disulf>
end case

Features [?]

From: PS52024
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       gL alphaherpesvirus-type #        
DISULFID     22     53           disulf   C-x*-C  
DISULFID     126     138           disulf   C-x*-C  

Additional information [?]

Size range 107-179 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P52510 (GL_GAHVG)
Viruses; Alphaherpesvirinae
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]