PRU01368

Accession	PRU01368
Dates	9-JUN-2023 (Created) 9-JUN-2023 (Last updated, Version 1)

Data class

Domain

Predictors

PROSITE; PS52024; GL_AHV

Name	Alphaherpesvirus glycoprotein L (gL) domain

Function

Two glycoprotein complexes are conserved throughout the three herpesvirus subfamilies: the trimeric glycoprotein B (gB) that functions as a membrane fusogen and the heterodimeric glycoprotein H/glycoprotein L (gH/gL), the role of which is less clearly defined. The intrinsic structural plasticity of gH/gL enables it to function as a signal integration machine that can accept diverse regulatory inputs and convert them into a "trigger" signal that activates the fusogenic ability of gB.

+ AltName: Full=Envelope glycoprotein L; Short=gL;

Function	The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.
Subunit	Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.
Subcellular location	Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.
Similarity	Belongs to the herpesviridae glycoprotein L (gL) family. Alphaherpesvirinae gL subfamily.

GO:0044177; Cellular component: host cell Golgi apparatus.
GO:0055036; Cellular component: virion membrane.
GO:0016020; Cellular component: membrane.
GO:0046718; Biological process: viral entry into host cell.
GO:0020002; Cellular component: host cell plasma membrane.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
GO:0019031; Cellular component: viral envelope.

Fusion of virus membrane with host cell membrane
Fusion of virus membrane with host membrane
Glycoprotein
Host Golgi apparatus
Host cell membrane
Host membrane
Membrane
Viral envelope protein
Viral penetration into host cytoplasm
Virion
Virus entry into host cell

Disulfide bond

From: PS52024

Key

From

To

Description

Tag

Condition

FTGroup

DOMAIN

from

to

gL alphaherpesvirus-type #

DISULFID

22

53

disulf

C-x*-C

DISULFID

126

138

disulf

C-x*-C

Size range	107-179 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	P52510 (GL_GAHVG)
Scope	Viruses; Alphaherpesvirinae
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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• UniProtKB/Swiss-Prot sets
  

  Viruses

  [12]

  
  
• Retrieve set of proteins with 3D structure for this domain