ProRule PRU01374

General rule information [?]

Accession PRU01374
Dates 5-JUL-2023 (Created)
-- (Last updated, Version 1)
Data class Domain;
Predictors PROSITE; PS52030; SMDRR
Name Streptococcal M proteins D repeat
Function M proteins belong to a family of fibrous streptococcal surface proteins which represent major virulence factors due to their antiphagocytic activities. All M proteins share a common framework that includes a conserved signal peptide, a hypervariable amino terminus, a less variable central domain, and a highly conserved C-terminus. A number of repeat sequences (A, B, C and D repeats) follow the hypervariable region. Sequence conservation increases from the A repeats to D repeats.
Scope(s) Bacteria
Example(s) Q5X9Q9 (M6A_STRP6);

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONSecreted, cell wall; Peptidoglycan-anchor.
SIMILARITYBelongs to the M protein family.

Keywords [?]

Gene Ontology [?]

GO:0005576; Cellular component:extracellular region

Features [?]

From: PS52030
Key From To Description Tag Condition FTGroup
REPEAT from 6 /note="D #"
REPEAT 7 12 /note="D #"
REPEAT 15 20 /note="D #"
REPEAT 22 to /note="D #"

Additional information [?]

Size range 27-27 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]