We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01374
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01374
General rule information
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| Accession | PRU01374 |
| Dates | 05-JUL-2023 (Created)
05-JUL-2023 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52030; SMDRR |
Name | Streptococcal M proteins D repeat |
| Function | M proteins belong to a family of fibrous streptococcal surface proteins which represent major virulence factors due to their antiphagocytic activities. All M proteins share a common framework that includes a conserved signal peptide, a hypervariable amino terminus, a less variable central domain, and a highly conserved C-terminus. A number of repeat sequences (A, B, C and D repeats) follow the hypervariable region. Sequence conservation increases from the A repeats to D repeats. |
| Scope(s) |
Bacteria Streptococcus |
| Example(s) | Q5X9Q9; |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Secreted, cell wall; Peptidoglycan-anchor. |
| SIMILARITY | Belongs to the M protein family. |
Keywords
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Gene Ontology
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| GO:0005576; Cellular component:extracellular region |
Features
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| From: PS52030 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REPEAT | from | 6 | /note="D #" | |||||||||
| REPEAT | 7 | 12 | /note="D #" | |||||||||
| REPEAT | 15 | 20 | /note="D #" | |||||||||
| REPEAT | 22 | to | /note="D #" | |||||||||
Additional information
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| Size range | 27-27 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [13] All [ 13 ]
- Retrieve set of proteins with 3D structure for this domain