ProRule PRU01374
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01374 |
| Accession | PRU01374 |
| Dates | 5-JUL-2023 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52030; SMDRR |
Name | Streptococcal M proteins D repeat |
| Function | M proteins belong to a family of fibrous streptococcal surface proteins which represent major virulence factors due to their antiphagocytic activities. All M proteins share a common framework that includes a conserved signal peptide, a hypervariable amino terminus, a less variable central domain, and a highly conserved C-terminus. A number of repeat sequences (A, B, C and D repeats) follow the hypervariable region. Sequence conservation increases from the A repeats to D repeats. |
| Scope(s) |
Bacteria Streptococcus |
| Example(s) | Q5X9Q9 (M6A_STRP6); |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Secreted, cell wall; Peptidoglycan-anchor. |
| SIMILARITY | Belongs to the M protein family. |
Keywords
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Gene Ontology
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| GO:0005576; Cellular component:extracellular region |
Features
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| From: PS52030 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REPEAT | from | 6 | /note="D #" | |||||||||
| REPEAT | 7 | 12 | /note="D #" | |||||||||
| REPEAT | 15 | 20 | /note="D #" | |||||||||
| REPEAT | 22 | to | /note="D #" | |||||||||
Additional information
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| Size range | 27-27 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [13] All [ 13 ]
- Retrieve set of proteins with 3D structure for this domain