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General rule information [?]

Accession PRU01374
Dates 5-JUL-2023 (Created)
5-JUL-2023 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS52030; SMDRR
Name Streptococcal M proteins D repeat
Function M proteins belong to a family of fibrous streptococcal surface proteins which represent major virulence factors due to their antiphagocytic activities. All M proteins share a common framework that includes a conserved signal peptide, a hypervariable amino terminus, a less variable central domain, and a highly conserved C-terminus. A number of repeat sequences (A, B, C and D repeats) follow the hypervariable region. Sequence conservation increases from the A repeats to D repeats.

Propagated annotation [?]

Comments [?]

Subcellular location Secreted, cell wall; Peptidoglycan-anchor.
Similarity Belongs to the M protein family.

Gene Ontology [?]

GO:0005576; Cellular component: extracellular region.

Keywords [?]

Features [?]

From: PS52030
Key     From     To       Description   Tag   Condition   FTGroup
REPEAT     from     6       D #        
REPEAT     7     12       D #        
REPEAT     15     20       D #        
REPEAT     22     to       D #        

Additional information [?]

Size range 27-27 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q5X9Q9 (M6A_STRP6)
Bacteria; Streptococcus
Comments None


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