PRU01374
General rule information
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| Accession | PRU01374 |
| Dates | 5-JUL-2023 (Created) 5-JUL-2023 (Last updated, Version 1) |
| Data class | Domain |
| Predictors | PROSITE; PS52030; SMDRR |
| Name | Streptococcal M proteins D repeat |
| Function | M proteins belong to a family of fibrous streptococcal surface proteins which represent major virulence factors due to their antiphagocytic activities. All M proteins share a common framework that includes a conserved signal peptide, a hypervariable amino terminus, a less variable central domain, and a highly conserved C-terminus. A number of repeat sequences (A, B, C and D repeats) follow the hypervariable region. Sequence conservation increases from the A repeats to D repeats. |
Propagated annotation
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Comments
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| Subcellular location | Secreted, cell wall; Peptidoglycan-anchor. |
| Similarity | Belongs to the M protein family. |
Gene Ontology
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GO:0005576; Cellular component: extracellular region.
Keywords
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Features
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| From: PS52030 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REPEAT | from | 6 | D # | |||||||||
| REPEAT | 7 | 12 | D # | |||||||||
| REPEAT | 15 | 20 | D # | |||||||||
| REPEAT | 22 | to | D # | |||||||||
Additional information
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| Size range | 27-27 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q5X9Q9 (M6A_STRP6) |
| Scope | Bacteria; Streptococcus |
| Comments | None |
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