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ProRule PRU01382


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PURL: https://purl.expasy.org/prosite/rule/PRU01382
General rule information [?]

Accession PRU01382
Dates 19-SEP-2023 (Created)
19-SEP-2023 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52038; TOPO_IB_2
Name Topoisomerase (Topo) IB-type catalytic domain
Function The RKKRH/N "catalytic pentad", conserved in all members of the topo IB family, catalyzes the attack of the active site tyrosine nucleophile on the scissile phosphodiester.
Scope(s) Eukaryota
Viruses
Nucleocytoviricota
Example(s) Q8R4U6 (TOP1M_MOUSE);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTTag:act_site>
Protein name + AltName: EC=5.6.2.1;

Comments [?]

CATALYTIC ACTIVITYReaction=ATP-independent breakage of single- stranded DNA, followed by passage and rejoining.; EC=5.6.2.1;
SIMILARITYBelongs to the type IB topoisomerase family.

Keywords [?]

DNA-binding
case <FTTag:act_site>
Isomerase
Topoisomerase
end case

Gene Ontology [?]

GO:0003917; Molecular function:DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0006265; Biological process:DNA topological change
end case
GO:0003677; Molecular function:DNA binding

Cross-references [?]

PROSITE PS00176; TOPO_IB_1; 1;

Features [?]

From: PS52038
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Topo IB-type catalytic #"
ACT_SITE 262 262 /note="O-(3'-phospho-DNA)-tyrosine intermediate" act_site Y

Additional information [?]

Size range 238-475 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]