ProRule PRU01382

General rule information [?]

Accession PRU01382
Dates 19-SEP-2023 (Created)
-- (Last updated, Version 1)
Data class Domain;
Predictors PROSITE; PS52038; TOPO_IB_2
Name Topoisomerase (Topo) IB-type catalytic domain
Function The RKKRH/N "catalytic pentad", conserved in all members of the topo IB family, catalyzes the attack of the active site tyrosine nucleophile on the scissile phosphodiester.
Scope(s) Eukaryota
Example(s) Q8R4U6 (TOP1M_MOUSE);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTTag:act_site>
Protein name + AltName: EC=;

Comments [?]

CATALYTIC ACTIVITYReaction=ATP-independent breakage of single- stranded DNA, followed by passage and rejoining.; EC=;
SIMILARITYBelongs to the type IB topoisomerase family.

Keywords [?]

case <FTTag:act_site>
end case

Gene Ontology [?]

GO:0003917; Molecular function:DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0006265; Biological process:DNA topological change
end case
GO:0003677; Molecular function:DNA binding

Cross-references [?]

PROSITE PS00176; TOPO_IB_1; 1;

Features [?]

From: PS52038
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Topo IB-type catalytic #"
ACT_SITE 262 262 /note="O-(3'-phospho-DNA)-tyrosine intermediate" act_site Y

Additional information [?]

Size range 238-475 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]