We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01383
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01383
General rule information
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| Accession | PRU01383 |
| Dates | 28-SEP-2023 (Created)
28-SEP-2023 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52039; TOPO_IA_2 |
Name | Topoisomerase (Topo) IA-type catalytic domain |
| Function | Topo IA form a transient 5'-phospho-tyrosine covalent intermediate and release a free 3'-OH strand. The Topo IA-type catalytic domain consisting of subdomains III, II and IV exhibits a typical toroidal shape with a central hole able to accommodate single-strand or double-strand DNA. |
| Scope(s) |
Bacteria Archaea Eukaryota Viruses Mimivirus bradfordmassiliense |
| Example(s) | Q9NG98; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the type IA topoisomerase family. |
Keywords
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| Isomerase | |
| Topoisomerase | |
| end case | |
| DNA-binding | |
Gene Ontology
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| GO:0003677; Molecular function:DNA binding | |
| case <FTTag:act_site> | |
| GO:0003917; Molecular function:DNA topoisomerase type I (single strand cut, ATP-independent) activity | |
Cross-references
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| PROSITE | PS00396; TOPO_IA_1; 1; |
Features
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| From: PS52039 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Topo IA-type catalytic #" | |||||||||
| ACT_SITE | 158 | 158 | /note="O-(5'-phospho-DNA)-tyrosine intermediate" | act_site | Y | |||||||
Additional information
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| Size range | 269-889 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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