ProRule PRU01383
General rule information
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| Accession | PRU01383 |
| Dates | 28-SEP-2023 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52039; TOPO_IA_2 |
Name | Topoisomerase (Topo) IA-type catalytic domain |
| Function | Topo IA form a transient 5'-phospho-tyrosine covalent intermediate and release a free 3'-OH strand. The Topo IA-type catalytic domain consisting of subdomains III, II and IV exhibits a typical toroidal shape with a central hole able to accommodate single-strand or double-strand DNA. |
| Scope(s) |
Bacteria Archaea Eukaryota Viruses Mimivirus bradfordmassiliense |
| Example(s) | Q9NG98 (TOP3A_DROME); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the type IA topoisomerase family. |
Keywords
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| Isomerase | |
| Topoisomerase | |
| end case | |
| DNA-binding | |
Gene Ontology
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| GO:0003677; Molecular function:DNA binding | |
| case <FTTag:act_site> | |
| GO:0003917; Molecular function:DNA topoisomerase type I (single strand cut, ATP-independent) activity | |
Cross-references
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| PROSITE | PS00396; TOPO_IA_1; 1; |
Features
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| From: PS52039 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Topo IA-type catalytic #" | |||||||||
| ACT_SITE | 158 | 158 | /note="O-(5'-phospho-DNA)-tyrosine intermediate" | act_site | Y | |||||||
Additional information
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| Size range | 269-889 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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