ProRule PRU01385
General rule information
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| Accession | PRU01385 |
| Dates | 13-OCT-2023 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52041; TOPO_IIB |
Name | Topoisomerase (Topo) IIB-type catalytic domain |
| Function | DNA cleavage by topo VI generates two-nucleotide 5'-protruding ends. |
| Scope(s) |
Archaea Eukaryota |
| Example(s) | Q9M4A2 (SPO11_ARATH); |
Propagated annotation
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Identifier, protein and gene names
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| case <FTTag:act_site> | |
| Protein name | + AltName: EC=5.6.2.2; |
| end case | |
Comments
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| case <FTTag:act_site> | |
| CATALYTIC ACTIVITY | Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2; |
| end case | |
| SIMILARITY | Belongs to the TOP6A family. |
Keywords
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| Isomerase | |
| Topoisomerase | |
| end case | |
| DNA-binding | |
Gene Ontology
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| GO:0003677; Molecular function:DNA binding | |
| case <FTTag:act_site> | |
| GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Features
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| From: PS52041 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Topo IIA-type catalytic #" | |||||||||
| ACT_SITE | 95 | 95 | /note="O-(5'-phospho-DNA)-tyrosine intermediate" | act_site | Y | |||||||
Additional information
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| Size range | 92-151 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [18] Eukaryota [18] All [ 36 ]
- Retrieve set of proteins with 3D structure for this domain