ProRule PRU01385

General rule information [?]

Accession PRU01385
Dates 13-OCT-2023 (Created)
-- (Last updated, Version 1)
Data class Domain;
Predictors PROSITE; PS52041; TOPO_IIB
Name Topoisomerase (Topo) IIB-type catalytic domain
Function DNA cleavage by topo VI generates two-nucleotide 5'-protruding ends.
Scope(s) Archaea
Example(s) Q9M4A2 (SPO11_ARATH);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTTag:act_site>
Protein name + AltName: EC=;
end case

Comments [?]

case <FTTag:act_site>
CATALYTIC ACTIVITYReaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=;
end case
SIMILARITYBelongs to the TOP6A family.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
case <FTTag:act_site>
GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

Features [?]

From: PS52041
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Topo IIA-type catalytic #"
ACT_SITE 95 95 /note="O-(5'-phospho-DNA)-tyrosine intermediate" act_site Y

Additional information [?]

Size range 92-151 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]