We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01385
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01385
General rule information
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| Accession | PRU01385 |
| Dates | 13-OCT-2023 (Created)
13-OCT-2023 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52041; TOPO_IIB |
Name | Topoisomerase (Topo) IIB-type catalytic domain |
| Function | DNA cleavage by topo VI generates two-nucleotide 5'-protruding ends. |
| Scope(s) |
Archaea Eukaryota |
| Example(s) | Q9M4A2; |
Propagated annotation
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Identifier, protein and gene names
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| case <FTTag:act_site> | |
| Protein name | + AltName: EC=5.6.2.2; |
| end case | |
Comments
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| case <FTTag:act_site> | |
| CATALYTIC ACTIVITY | Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2; |
| end case | |
| SIMILARITY | Belongs to the TOP6A family. |
Keywords
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| Isomerase | |
| Topoisomerase | |
| end case | |
| DNA-binding | |
Gene Ontology
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| GO:0003677; Molecular function:DNA binding | |
| case <FTTag:act_site> | |
| GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Features
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| From: PS52041 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Topo IIA-type catalytic #" | |||||||||
| ACT_SITE | 95 | 95 | /note="O-(5'-phospho-DNA)-tyrosine intermediate" | act_site | Y | |||||||
Additional information
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| Size range | 92-151 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [18] Eukaryota [18] All [ 36 ]
- Retrieve set of proteins with 3D structure for this domain