ProRule PRU01389
General rule information
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| Accession | PRU01389 |
| Dates | 30-MAY-2024 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52044; VLRF1 |
Name | Vms1-like release factor 1 (VLRF1) domain |
| Function | The ANKZF1/Vms1 Vms1-like release factor 1 (VLRF1) domain, which acts as a peptidyl-tRNA hydrolase, has a catalytic loop bearing a conserved glutamine. In addition to the glutamine in the active site, the VLRF1 domain also contains conserved vicinal arginines in the alpha-helix immediately following the active-site loop. The cleavage mechanism involves remodelling and cleavage of the ribose-phosphate backbone of the tRNA by a tyrosine and the GSQ motif. |
| Scope(s) |
Eukaryota |
| Example(s) | Q80UU1 (ANKZ1_MOUSE); |
Propagated annotation
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Comments
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| DOMAIN | The VLRF1 domain mediates binding to the 60S ribosomal subunit. |
| SIMILARITY | Belongs to the ANKZF1/VMS1 family. |
Keywords
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| Cytoplasm | |
| case <FT:2> | |
| Endonuclease | |
| Hydrolase | |
| Nuclease | |
| end case | |
Gene Ontology
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| GO:0005737; Cellular component:cytoplasm |
Features
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| From: PS52044 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="VLRF1 #" | |||||||||
| ACT_SITE | 44 | 44 | Q | |||||||||
Additional information
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| Size range | 142-161 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [7] All [ 7 ]
- Retrieve set of proteins with 3D structure for this domain