We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01389
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01389
General rule information
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| Accession | PRU01389 |
| Dates | 30-MAY-2024 (Created)
30-MAY-2024 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52044; VLRF1 |
Name | Vms1-like release factor 1 (VLRF1) domain |
| Function | The ANKZF1/Vms1 Vms1-like release factor 1 (VLRF1) domain, which acts as a peptidyl-tRNA hydrolase, has a catalytic loop bearing a conserved glutamine. In addition to the glutamine in the active site, the VLRF1 domain also contains conserved vicinal arginines in the alpha-helix immediately following the active-site loop. The cleavage mechanism involves remodelling and cleavage of the ribose-phosphate backbone of the tRNA by a tyrosine and the GSQ motif. |
| Scope(s) |
Eukaryota |
| Example(s) | Q80UU1; |
Propagated annotation
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Comments
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| DOMAIN | The VLRF1 domain mediates binding to the 60S ribosomal subunit. |
| SIMILARITY | Belongs to the ANKZF1/VMS1 family. |
Keywords
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| Cytoplasm | |
| case <FT:2> | |
| Endonuclease | |
| Hydrolase | |
| Nuclease | |
| end case | |
Gene Ontology
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| GO:0005737; Cellular component:cytoplasm |
Features
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| From: PS52044 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="VLRF1 #" | |||||||||
| ACT_SITE | 44 | 44 | Q | |||||||||
Additional information
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| Size range | 142-161 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [7] All [ 7 ]
- Retrieve set of proteins with 3D structure for this domain