ProRule PRU01393
General rule information
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| Accession | PRU01393 |
| Dates | 8-AUG-2024 (Created)
13-SEP-2024 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52048; UCH_DOMAIN |
Name | Ubiquitin carboxyl-terminal hydrolase (UCH) catalytic domain |
| Function | Ubiquitin C-terminal hydrolases (UCHs) are deubiquitinating enzymes which hydrolyze C-terminal esters and amides of ubiquitin. They have a catalytic core domain consisting of about 230 amino acids. |
| Scope(s) |
Eukaryota |
| Example(s) | Q6SEG5 (UCHL1_PIG); |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> | |
| Protein name | + RecName: EC=3.4.19.12; |
Comments
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| CATALYTIC ACTIVITY | Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; |
| end case | |
| SIMILARITY | Belongs to the peptidase C12 family. |
Keywords
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Gene Ontology
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| GO:0004843; Molecular function:cysteine-type deubiquitinase activity |
| GO:0006511; Biological process:ubiquitin-dependent protein catabolic process |
Cross-references
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| PROSITE | PS00140; UCH_1; 0-1; |
Features
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| From: PS52048 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="UCH catalytic #" | |||||||||
| ACT_SITE | 88 | 88 | /note="Nucleophile" | C | 1 | |||||||
| ACT_SITE | 163 | 163 | /note="Proton donor" | H | 1 | |||||||
| SITE | 82 | 82 | /note="Transition state stabilizer" | Q | 1 | |||||||
| SITE | 178 | 178 | /note="Important for enzyme activity" | D | 1 | |||||||
Additional information
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| Size range | 209-323 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [53] All [ 53 ]
- Retrieve set of proteins with 3D structure for this domain