ProRule PRU01421
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PURL: https://purl.expasy.org/prosite/rule/PRU01421
General rule information
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| Accession | PRU01421 |
| Dates | -- (Created)
-- (Last updated, Version ) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52076; IFN_II |
Name | Interferon (IFN) type-II family |
| Function | Tetrapods possess only a single copy of type II IFN gene, called IFN-gamma, which is mainly involved in immune regulation. In general, teleost fish are reported to have the composition of two type II IFN genes, including IFN-gamma and IFN-gamma-related (IFN-gammarel), except that two IFN-gamma genes were identified in channel catfish (named as IFN-gamma2a and IFN- gamma2b) and in ginbuna crucian carp (IFN-gamma1 and IFN-gamma2), and two IFN-gammarel genes were also reported in ginbuna crucian carp (IFN-gammarel1 and IFN-gammarel2). Three members of type II IFN family, named as IFN-gamma- like, IFN-gamma and IFN-gammarel, were identified in the osteoglossiform fish, arapaima. IFN-gamma does possess some antiviral activity but is mainly an immunomodulatory cytokine acting on leukocytes. |
| Scope(s) |
Eukaryota Euteleostomi |
| Example(s) | P79154; |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Secreted. |
| SIMILARITY | Belongs to the type II (or gamma) interferon family. |
Keywords
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| Cytokine | |
| Secreted | |
| Antiviral defense | |
| Growth regulation | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| GO:0005133; Molecular function:type II interferon receptor binding |
| GO:0005125; Molecular function:cytokine activity |
| GO:0005615; Cellular component:extracellular space |
| GO:0002250; Biological process:adaptive immune response |
| GO:0006959; Biological process:humoral immune response |
| GO:0051607; Biological process:defense response to virus |
Cross-references
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| PROSITE | PS00001; ASN_GLYCOSYLATION; 0-1; |
Features
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| From: PS52076 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DISULFID | 40 | 42 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 128-175 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [49] All [ 49 ]
- Retrieve set of proteins with 3D structure for this domain