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ProRule PRU01422


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PURL: https://purl.expasy.org/prosite/rule/PRU01422
General rule information [?]

Accession PRU01422
Dates -- (Created)
-- (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS52077; IFN_III
Name Interferon (IFN) type-III family
Function Type III IFNs, commonly known as interferon lambda (IFNL or IFN- lambda), have been reported in mammals, birds, reptiles, amphibians, and cartilaginous fish. IFN-IIIs include IFN-lambda1-3 (also known as interleukin [IL]-29, IL-28A, and IL-28B) and IFN-lambda4 (only IFN-lambda2 and IFN- lambda3 exist in mice). They play a crucial role as gatekeepers, particularly in safeguarding mucosal epithelial cells.
Scope(s) Eukaryota
Euteleostomi
Example(s) Q8IU54;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONSecreted.
SIMILARITYBelongs to the type-III (or lambda) interferon family.

Keywords [?]

Antiviral defense
Cytokine
Secreted
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
Disulfide bond
end case
case (<Feature:PS52077:3-102=C-x*-C> and <Feature:PS52077:35-135=C-x*-C> and<Feature:PS52077:48-161=C-x*-C>)
else case (<Feature:PS52077:3-102=C-x*-C> and <Feature:PS52077:37-135=C-x*-C> and<Feature:PS52077:154-161=C-x*-C>)

Gene Ontology [?]

GO:0005125; Molecular function:cytokine activity
GO:0050778; Biological process:positive regulation of immune response
GO:0051607; Biological process:defense response to virus
GO:0005615; Cellular component:extracellular space
GO:0045087; Biological process:innate immune response
GO:0005102; Molecular function:signaling receptor binding

Cross-references [?]

PROSITE PS00001; ASN_GLYCOSYLATION; 0-1;

Features [?]

From: PS52077
Key From To Description Tag Condition FTGroup
case (<Feature:PS52077:3-102=C-x*-C> and <Feature:PS52077:35-135=C-x*-C> and<Feature:PS52077:48-161=C-x*-C>)
DISULFID 3 102 1
DISULFID 35 135 1
DISULFID 48 161 1
else case (<Feature:PS52077:3-102=C-x*-C> and <Feature:PS52077:37-135=C-x*-C> and<Feature:PS52077:154-161=C-x*-C>)
DISULFID 3 102 2
DISULFID 37 135 2
DISULFID 154 161 2
else case (<Feature:PS52077:37-135=C-x*-C>)
DISULFID 37 135 C-x*-C 3
end case

Additional information [?]

Size range 155-162 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]